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Gilenya, or Fingolimod, is the first approved oral disease modifying drug for MS.

Comparison of Gilenya with Avonex in relapsing-remitting MS

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Summary

Background

In a 12-month phase 3 study in patients with relapsing-remitting multiple sclerosis (RRMS), TRANSFORMS, fingolimod showed greater efficacy on relapse rates and MRI outcomes compared with interferon beta-1a. We had two aims in our extension: to compare year 2 with year 1 in the switched patients to assess the effect of a change from interferon beta-1a to fingolimod, and to compare over 24 months the treatment groups as originally randomised to assess ...
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Cardiovascular effects of oral MS drug Gilenya transient

Cardiovascular effects of oral MS drug Gilenya mostly transient

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The first approved oral medication for multiple sclerosis causes transient reductions in heart rate and atrioventricular conduction and a sustained increase in blood pressure, according to investigators who analyzed pooled data from two phase III trials.

The cohorts from the two phase III clinical trials of fingolimod (Gilenya) for relapsing-remitting muscular sclerosis involved 854 patients treated with the currently approved dosage offingolimod (0.5 mg/day), 849 ...
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Reducing the side effects of MS drug, Gilenya

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The drug Gilenya (FTY720) is approved for the treatment of multiple sclerosis. Although highly effective it can have serious side effects, including reduced lung function and fluid accumulation in the eye.

Understanding the multiple molecular mechanisms by which the drug affects its target (the S1P receptor) could lead to the development of a drug with the same therapeutic efficacy but reduced side effects.
In this context, a team of researchers, led by Timothy Hla, ...
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Oral MS drug Gilenya has yet to show ‘full potential'

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Novartis's multiple sclerosis pill Gilenya, which faces a threat from a rival product under development by Biogen Idec Inc, has yet to show its full potential, the Swiss drugmaker’s head of development said.

Gilenya, approved by U.S. regulators last year as the first pill against relapsing forms of multiple sclerosis, may also work in patients with a more severe form of the disease called primary progressive, Novartis’s Trevor Mundel said yesterday in a telephone ...
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First oral MS drug, Gilenya, now available in UK

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A new drug for multiple sclerosis that is twice as effective as the current standard treatment is now available in the UK.

Fingolimod - also known by its brand name Gilenya - is the first pill available to treat MS.


It has been licensed by the European medicines watchdog to treat patients with relapsing-remitting MS who have failed to respond to injections of beta interferon.

Studies show it reduces the relapse rate by 54% ...
Read more : First oral MS drug, Gilenya, now available in UK | Views : 1182 | Replies : 0


Gilenya reduced the risk of MS disability progression

Gilenya reduced the risk of MS disability progression regardless of treatment history or disease severity

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A new analysis demonstrated that Gilenya(TM) (fingolimod) reduced the risk of disability progression in patients with relapsing-remitting multiple sclerosis (RRMS), regardless of treatment history.

This analysis of the phase III two-year FREEDOMS study is one of 11 abstracts on Gilenya being presented at the 63rd annual meeting of the American Academy of Neurology (AAN).

"In developing Gilenya, Novartis initiated ...
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Dubai health authority backs new oral medication for MS

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The UAE's Multiple Sclerosis (MS) community is set to become the first in the region to benefit from a new oral medication designed to reduce debilitating symptoms and prevent disability, it was announced today by Dr. Ali Al Sayed, Director of Pharmaceutical Services, Dubai Health Authority (DHA).

Dr. Al Sayed said the new therapy called Gilenya (fingolimod) is now available in the UAE after being approved as a first-line treatment in a number of ...
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Gilenya, the first oral MS treatment, approved in Europe

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The European Commission has granted Novartis approval for Gilenya® (fingolimod) 0.5 mg daily as a disease modifying therapy in patients with highly active relapsing-remitting multiple sclerosis (RRMS) despite treatment with beta interferon, or in patients with rapidly evolving severe RRMS.

"Today marks an important step forward in the way we manage this chronic, debilitating disease in Europe,” said Professor Hans-Peter Hartung, Professor and Chairman, Dept. of Neurology, Heinrich-Heine University, Germany. “Gilenya is the first ...
Read more : Gilenya, the first oral MS treatment, approved in Europe | Views : 1205 | Replies : 0


Humble reminder

Humble reminder that this while doing great things IS NOT A CURE!!!
I DO feel a MILLION times better but for the past 2 days have had a couple of old altered sensation symptoms "flare up" in my arms & legs, not enough to hurt, but enough to slow me down, be VERY annoying & put me back on a pulse steroid for a couple of days. Not a big deal, but a bit of ...
Read more : Humble reminder | Views : 2646 | Replies : 11


Week #2

So it's off to a good start! Still sleeping great & waking at normal hours feeling rested & ready to go. Noticing that bladder & bowl functions have returned to NORMAL. Really appreciative of that & hoping that perhaps my libido will return to normal again soon... anyone else who understands how difficult that loss can be on a marriage will also understand my desire for its return!
Read more : Week #2 | Views : 1572 | Replies : 2


 

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