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A board to discuss the Multiple Sclerosis modifying drug Novantrone

Safety & efficacy of mitoxantrone in pediatric MS patients

Safety and efficacy of mitoxantrone in pediatric patients with aggressive MS

Abstract

OBJECTIVE: The purpose of this study was to assess the safety and efficacy of mitoxantrone (MX) in pediatric patients with aggressive multiple sclerosis (MS).

METHODS: A retrospective analysis on pediatric MS patients treated with MX was performed with regards to demographic/clinical parameters and magnetic resonance imaging (MRI) findings..... Read More - http://www.ms-uk.org/paediatric
Read more : Safety & efficacy of mitoxantrone in pediatric MS patients | Views : 3296 | Replies : 0


Novantrone for MS 5-year phase IV RENEW study results report

Novantrone for MS 5-year phase IV RENEW study results reported

Registry to Evaluate Novantrone Effects in Worsening Multiple Sclerosis (RENEW) was a 5-year, phase IV study in which the safety of Mitoxantrone was monitored in a patient cohort from the United States (US). The objective of the study was to evaluate the long-term safety profile of Mitoxantrone in patients with secondary progressive multiple sclerosis (SPMS), progressive relapsing multiple sclerosis (PRMS), and worsening relapsing-remitting multiple sclerosis ...
Read more : Novantrone for MS 5-year phase IV RENEW study results report | Views : 1109 | Replies : 0


Acute myeloid leukemia in MS patients treated with MTX

Acute myeloid leukemia in Italian MS patients treated with mitoxantrone

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Summary: The Italian Mitoxantrone group report data following their evaluation of the incidence and dose-dependency of mitoxantrone (MTX)-associated acute myelocytic leukemia (AML)

This multicentre study was performed retrospectively and incorporates data from 3,220 patients (63% women) from 40 Italian MS centres. 30 cases of AML in total were identified and as might be expected the mean cumulative dose of MTX was higher in patients ...
Read more : Acute myeloid leukemia in MS patients treated with MTX | Views : 3068 | Replies : 1


Never tested after Novantrone treatments?

I have RRMS and my neuro agreed that Novantrone would benefit me. I went for the initial cardio testing, took 3 treatments (he wanted 6), and sent me on my merry way. That was October, November & December of 2008.

The FDA sent out a notice for prescribing Drs' to test patients after their treatments, as problems could arise years after treatment in July of 2008. Ongoing testing was never mentioned to me.

I am ...
Read more : Never tested after Novantrone treatments? | Views : 1942 | Replies : 1


Adverse events associated with mitoxantrone for MS

Cardiotoxicity & other adverse events associated with mitoxantrone for MS

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Background: Mitoxantrone is used for aggressive multiple sclerosis (MS), but concerns about safety, including cardiotoxicity and other laboratory measures, prevail.

Objective: To evaluate the incidence and potential predictors of adverse events associated with mitoxantrone at the MS Clinic, University of British Columbia, Canada.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... pageid/698
Read more : Adverse events associated with mitoxantrone for MS | Views : 2045 | Replies : 0


Chemo anyone?

Has anyone done chemo therapy for their MS. Novaantrone does not seem to help anyone with their symptoms.

Anyone try cyclophosphamide? If so how did you do? I have done quite a bit of reading on it, andd people who have taken seem to have gotten good results.

If you are on cyclophosphamide how did / do you get it?

Im at the end of my rope with MS. It has taken so much from ...
Read more : Chemo anyone? | Views : 2055 | Replies : 1


Considering Novantrone/Campath

Hi,

My MS has gradually worsened (walking more unstable) over a year, and my neuro suggested I look at Novantrone as an option -- see ehat 3 doses woul;d do etc.

I was wondering though, if I went for this option would it complicate using Campath -- or Revimmune -- in the future? Was thinking in terms of supressed immunity with a chemo drug and then problems using a monoclonal antibody.

Any input welcome! Also ...
Read more : Considering Novantrone/Campath | Views : 2027 | Replies : 0


Health insurance

I was booted from my state coverage when I was awarded Social Security in July. Which means, I don't have coverage and can't find a carrier who will cover me. I'm so scared. I have notified my senator, the insurance commissioner, and every MS organization I can think of.

Does anyone know where I can go?

Doctors won't see w/out coverage so I can't get a prescription for anything. Where should I be looking?

Any ...
Read more : Health insurance | Views : 2335 | Replies : 1


Novantrone questions

If anyone still gets on here
My Dr's want to start me on Novantrone due to my MS worstening over the last year.
Thoughts good or bad would be greatly appreciated
Read more : Novantrone questions | Views : 3540 | Replies : 6


Novantrone and Leukemia and Greater Heart Damage Risk

My husband was diagnosed in early September 2008 as having Acute Myelogenous Leukemia (AML) Secondary to administration of Novantrone.

There are three other patients on his hospital floor with the same problem. I think that the public has been underquoted the risk. If the risk that the Novantrone mfg quoted to doctors was 1 in 1000 (as I am told), I actually calculated the risks from their small lot of studies as 1 in 400 ...
Read more : Novantrone and Leukemia and Greater Heart Damage Risk | Views : 4408 | Replies : 7


 

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