Acute myeloid leukemia in Italian MS patients treated with mitoxantrone



Summary: The Italian Mitoxantrone group report data following their evaluation of the incidence and dose-dependency of mitoxantrone (MTX)-associated acute myelocytic leukemia (AML)

This multicentre study was performed retrospectively and incorporates data from 3,220 patients (63% women) from 40 Italian MS centres. 30 cases of AML in total were identified and as might be expected the mean cumulative dose of MTX was higher in patients ...

I have RRMS and my neuro agreed that Novantrone would benefit me. I went for the initial cardio testing, took 3 treatments (he wanted 6), and sent me on my merry way. That was October, November & December of 2008.

The FDA sent out a notice for prescribing Drs' to test patients after their treatments, as problems could arise years after treatment in July of 2008. Ongoing testing was never mentioned to me.

I am ...

Cardiotoxicity & other adverse events associated with mitoxantrone for MS



Background: Mitoxantrone is used for aggressive multiple sclerosis (MS), but concerns about safety, including cardiotoxicity and other laboratory measures, prevail.

Objective: To evaluate the incidence and potential predictors of adverse events associated with mitoxantrone at the MS Clinic, University of British Columbia, Canada.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... pageid/698

Has anyone done chemo therapy for their MS. Novaantrone does not seem to help anyone with their symptoms.

Anyone try cyclophosphamide? If so how did you do? I have done quite a bit of reading on it, andd people who have taken seem to have gotten good results.

If you are on cyclophosphamide how did / do you get it?

Im at the end of my rope with MS. It has taken so much from ...

Hi,

My MS has gradually worsened (walking more unstable) over a year, and my neuro suggested I look at Novantrone as an option -- see ehat 3 doses woul;d do etc.

I was wondering though, if I went for this option would it complicate using Campath -- or Revimmune -- in the future? Was thinking in terms of supressed immunity with a chemo drug and then problems using a monoclonal antibody.

Any input welcome! Also ...

I was booted from my state coverage when I was awarded Social Security in July. Which means, I don't have coverage and can't find a carrier who will cover me. I'm so scared. I have notified my senator, the insurance commissioner, and every MS organization I can think of.

Does anyone know where I can go?

Doctors won't see w/out coverage so I can't get a prescription for anything. Where should I be looking?

Any ...

My husband was diagnosed in early September 2008 as having Acute Myelogenous Leukemia (AML) Secondary to administration of Novantrone.

There are three other patients on his hospital floor with the same problem. I think that the public has been underquoted the risk. If the risk that the Novantrone mfg quoted to doctors was 1 in 1000 (as I am told), I actually calculated the risks from their small lot of studies as 1 in 400 ...

My wife just started Novantrone.
Her MS has been getting much worse for 3 years now. She doesn't have relapses or remission, she has constant, daily problems walking. She falls alot even with her walker. She is in a freefall towards a wheelchair and she's only 38. The neurologist started her on Novantrone after several other drugs failed to do anything.
She got her first Infusion on Friday. All was fine. Saturday morning she could ...

I started Novantrone this past week. My MS was progressing so fast, and after 18 months of Betaseron, my doctor felt it was time to add another drug. I am 37 years old, and I am physically healthy--weight, bp, etc.

I would love to hear from people who have taken this drug, and I have noticed strands of my hair are starting to fall out. Losing my hair is a small price to pay to ...