This Is MS Multiple Sclerosis Community: Knowledge & Support

HI Friends please read

Multiple Sclerosis Drug Linked To Many More Cases Of Leukemia

http://www.healthcarepublication.com/mu ... -leukemia/

regards
seeva

Novantrone Prescribing Information

http://www.accessdata.fda.gov/drugsatfd ... 031lbl.pdf

Safety and efficacy of mitoxantrone in pediatric patients with aggressive MS

Abstract

OBJECTIVE: The purpose of this study was to assess the safety and efficacy of mitoxantrone (MX) in pediatric patients with aggressive multiple sclerosis (MS).

METHODS: A retrospective analysis on pediatric MS patients treated with MX was performed with regards to demographic/clinical parameters and magnetic resonance imaging (MRI) findings..... Read More - http://www.ms-uk.org/paediatric

Novantrone for MS 5-year phase IV RENEW study results reported

Registry to Evaluate Novantrone Effects in Worsening Multiple Sclerosis (RENEW) was a 5-year, phase IV study in which the safety of Mitoxantrone was monitored in a patient cohort from the United States (US). The objective of the study was to evaluate the long-term safety profile of Mitoxantrone in patients with secondary progressive multiple sclerosis (SPMS), progressive relapsing multiple sclerosis (PRMS), and worsening relapsing-remitting multiple sclerosis ...

Acute myeloid leukemia in Italian MS patients treated with mitoxantrone



Summary: The Italian Mitoxantrone group report data following their evaluation of the incidence and dose-dependency of mitoxantrone (MTX)-associated acute myelocytic leukemia (AML)

This multicentre study was performed retrospectively and incorporates data from 3,220 patients (63% women) from 40 Italian MS centres. 30 cases of AML in total were identified and as might be expected the mean cumulative dose of MTX was higher in patients ...

I have RRMS and my neuro agreed that Novantrone would benefit me. I went for the initial cardio testing, took 3 treatments (he wanted 6), and sent me on my merry way. That was October, November & December of 2008.

The FDA sent out a notice for prescribing Drs' to test patients after their treatments, as problems could arise years after treatment in July of 2008. Ongoing testing was never mentioned to me.

I am ...

Cardiotoxicity & other adverse events associated with mitoxantrone for MS



Background: Mitoxantrone is used for aggressive multiple sclerosis (MS), but concerns about safety, including cardiotoxicity and other laboratory measures, prevail.

Objective: To evaluate the incidence and potential predictors of adverse events associated with mitoxantrone at the MS Clinic, University of British Columbia, Canada.... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... pageid/698

Has anyone done chemo therapy for their MS. Novaantrone does not seem to help anyone with their symptoms.

Anyone try cyclophosphamide? If so how did you do? I have done quite a bit of reading on it, andd people who have taken seem to have gotten good results.

If you are on cyclophosphamide how did / do you get it?

Im at the end of my rope with MS. It has taken so much from ...

Hi,

My MS has gradually worsened (walking more unstable) over a year, and my neuro suggested I look at Novantrone as an option -- see ehat 3 doses woul;d do etc.

I was wondering though, if I went for this option would it complicate using Campath -- or Revimmune -- in the future? Was thinking in terms of supressed immunity with a chemo drug and then problems using a monoclonal antibody.

Any input welcome! Also ...

I was booted from my state coverage when I was awarded Social Security in July. Which means, I don't have coverage and can't find a carrier who will cover me. I'm so scared. I have notified my senator, the insurance commissioner, and every MS organization I can think of.

Does anyone know where I can go?

Doctors won't see w/out coverage so I can't get a prescription for anything. Where should I be looking?

Any ...