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Biomarkers for response to therapies

Having several disease modifying drugs available, is interesting to know what kind of response is expected for each one in a given patient.

Pharmacogenetic Biomarkers to Predict Treatment Response in Multiple Sclerosis: Current and Future Perspectives
Source: https://www.hindawi.com/journals/msi/2017/6198530/

The review only shows genes associated with responses to interferons, glatimer acetate and mitoxantrone. Could be interesting, anyway.
Read more : Biomarkers for response to therapies | Views : 104 | Replies : 1 | Forum : MS Etiology and Pathogenesis


microRNA miR-155 dysregulation

Authors of the article say that is not only a biomarker, but also a target for intervention. I put it here in biomarkers just to be conservative.

miR-155 Dysregulation and Therapeutic Intervention in Multiple Sclerosis.

Abstract

microRNAs play a fundamental role in the immune system. One particular microRNA, miR-155 plays a critical role in hematopoietic cell development and tightly regulates innate and adaptive immune responses in response to infection.

However, its dysregulation, more specifically its ...
Read more : microRNA miR-155 dysregulation | Views : 69 | Replies : 0 | Forum : MS Etiology and Pathogenesis


Nuro wants another MRI

I just had one 2 months ago and now she wants another to see if my Avonex is causing lesions.
Is this something on the common side for nuros to do? It's a good thing right now my ins is paying for my MRI's other wise I would of said hell no!
Read more : Nuro wants another MRI | Views : 119 | Replies : 0 | Forum : Avonex


CSF testing and other questions

I'm a 39 year old female, with a 4 year old and a 9 month old.
I've had an MRI that shows T2 hyper-intensities in 2 of the 4 areas of the brain that may indicate MS. However, both neurologists I have seen say that I do not have the traditional history or current symptoms of someone with MS, so I have had a CSF test done (awaiting results - ugh!) and I will go ...
Read more : CSF testing and other questions | Views : 103 | Replies : 1 | Forum : Undiagnosed


looking for a clinic to do MSCT

hi guys
i am from montreal(canada) and i am searching for a facility where i can do MSCT, but not too far from home. it will be nice if it is in vermont state, or the begining of new york state ( albany area for example).
any help or advice are welcome.
thanks in dvance and sorry for the faults, i have MS :-)
Read more : looking for a clinic to do MSCT | Views : 149 | Replies : 0 | Forum : Stem Cells


Association of Developmental Venous Anomalies with MS

Association of Developmental Venous Anomalies with Demyelinating Lesions in Patients with MS

Source: https://www.ncbi.nlm.nih.gov/pubmed/28912286

Abstract

We present 5 cases of demyelination in patients diagnosed with multiple sclerosis that are closely associated with a developmental venous anomaly.

Although the presence of a central vein is a known phenomenon with multiple sclerosis plaques, demyelination occurring around developmental venous anomalies is an underreported phenomenon.

Tumefactive demyelination can cause a diagnostic dilemma because ...


1st movement after waking triggers violent muscle spasms

When I wake up in the morning I get severe, sudden muscle spasms especially in my legs and back with my arms and hands spasming somewhat too. This happens every morning. The interesting thing is the spasms don't happen until I move a part of my body, even a little bit, like flexing my fingers. So, I wake up in bed and then the very first movement I make, no matter how small, sets off ...
Read more : 1st movement after waking triggers violent muscle spasms | Views : 536 | Replies : 52 | Forum : General Discussion


A review of PET in MS

Positron emision tomography (PET) can show things that cannot be seen under MRI. Specially interesting is that microglia, some inmune cells of the brain that are involved in the lesions, can be seen when they are activated (they present a protein called 18kda TSPO) in the NAWM (normal appearing white matter, areas in which the MS lesions appear).

Some extracts of the article here:


Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its ...
Read more : A review of PET in MS | Views : 201 | Replies : 0 | Forum : MS Etiology and Pathogenesis


Caroline Wyatt stem cell progress - latest press

This was reported in the UK press - she worked for the BBC and had HSCT in Jan this year


http://www.telegraph.co.uk/women/life/a ... nce-speak/
Read more : Caroline Wyatt stem cell progress - latest press | Views : 227 | Replies : 1 | Forum : Stem Cells


Vitamin D Levels in Blood May Help Predict Risk of MS

Examining vitamin D levels in the blood may help predict whether a person is at risk of developing multiple sclerosis (MS), according to a large new study published in an online issue of Neurology, the medical journal of the American Academy of Neurology...Read more - http://www.ms-uk.org/vitamin-d-levels-blood-may-help-predict-risk-ms
Read more : Vitamin D Levels in Blood May Help Predict Risk of MS | Views : 173 | Replies : 0 | Forum : General Discussion


 

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