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Phase I trial of ALKS 8700 to treat multiple sclerosis begin

Phase I trial of ALKS 8700 to treat multiple sclerosis begins

Ireland-based biopharmaceutical firm Alkermes has started a Phase I clinical trial of ALKS 8700, a novel monomethyl fumarate (MMF) molecule being developed for the treatment of multiple sclerosis (MS).

The trial will assess the safety, tolerability and pharmacokinetics of several oral formulations of ALKS 8700 compared to both placebo and active control groups in approximately 125 healthy volunteers......... Read More - http://www.ms-uk.org/emergingtherapies
Read more : Phase I trial of ALKS 8700 to treat multiple sclerosis begin | Views : 131 | Replies : 0 | Forum : Drug Pipeline


Neonatal vitamin D status and risk of multiple sclerosis

Neonatal vitamin D status and risk of multiple sclerosis

Ueda P, Rafatnia F, Bäärnhielm M, Fröbom R, Korzunowicz G, Lönnerbro R, Hedström AK, Eyles D, Olsson T, Alfredsson L.

Abstact

Objective: Low vitamin D status at birth may be associated with risk of adult onset multiple sclerosis, but this link has not been studied directly. We assessed the relation between neonatal vitamin D concentrations, measured in stored blood samples, and risk of multiple sclerosis...... Read ...
Read more : Neonatal vitamin D status and risk of multiple sclerosis | Views : 134 | Replies : 0 | Forum : General Discussion


Rash & red itchy spots

Hi, I'm having a problem that I don't think any others are having. Or I haven't found it yet. I have a small rash on my forehead and the whole forehead itches like crazy. I also have red itchy spots on my upper body. The body spots I know started with the med. I've put cortisone, coconut oil, and a campor salve on both, they don't help. A Benadril cuts it some. But I itch ...
Read more : Rash & red itchy spots | Views : 119 | Replies : 4 | Forum : Tecfidera (BG-12, dimethyl fumarate)


Which diet?

Two days ago I was diagnosed with ms and have been searching the web ever since, looking for ways to prevent this disease from attacking my body. Diet being one of the best ways mentioned, so I would like to know what diet do you guys recommend? I was looking at the different diet topics and noticed that the bbd diet had the most success stories out of all of them, so is this diet ...
Read more : Which diet? | Views : 211 | Replies : 7 | Forum : Diet


Over-the-counter antihistamine, Tavist, being tested

http://clinicaltrials.gov/show/NCT02040298

Is anyone taking this over the counter antihistamine and seeing any improvement in their symptoms?
Read more : Over-the-counter antihistamine, Tavist, being tested | Views : 202 | Replies : 2 | Forum : Drug Pipeline


Homocysteine decreases cerebral perfusion

I think that any discussion of endothelial health and cerebral perfusion is incomplete without considering homocysteine.

Resting brain perfusion and selected vascular risk factors in healthy elderly subjects.
PLoS One. 2014 May 19;9(5):e97363.

    BACKGROUND AND PURPOSE: Both cerebral hypoperfusion and vascular risk factors have been implicated in early aging of the brain and the development of neurodegenerative disease. However, the current knowledge of the importance of cardiovascular health on resting brain perfusion is limited. The ...


Alzheimer Nitric Oxide NOS2

Abstract:
Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease–like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric ...
Read more : Alzheimer Nitric Oxide NOS2 | Views : 176 | Replies : 1 | Forum : Chronic Cerebrospinal Venous Insufficiency (CCSVI)


"in our sameness we are all so different" LIKE A FINGERPRINT

I've always said we are individuals and dr.'s needed to listen to us as such, check us out every way possible etc. NOT give us a diag. that is still to this day based on an "auto immune "theory" only"! that we carry from that day forth like a monkey on your back- just so they can justify almost everything going on is because ya got these symptoms somebody decided to name ms. "forget that ...
Read more : "in our sameness we are all so different" LIKE A FINGERPRINT | Views : 145 | Replies : 0 | Forum : General Discussion


MS B12 Pacemaker

My docs tell me they are convinced that I have ms. I've had the symptoms for years but wrote them off to side effects from meds. When I went over the list of symptoms with my doctors--finally--saying "I am spiraling downward," and they observed my spasms, trembling, and then the double vision...well, you all know the story. I can't play my piano anymore.

But I'm not convinced entirely. I can't do an MRI because of ...
Read more : MS B12 Pacemaker | Views : 289 | Replies : 14 | Forum : General Discussion


I hope they say MS.. Crazy?

Once was a healthy person never seeing Dr..For the last few years have seen several: PCP, Rheumy, Orthoped and now Neurologist. UGH!

Numbness, weakness, tingling, itching, vertigo, fatigue, rib cramps and now this vibration like a tuning fork. All of these come and go. I never now how long the symptoms will last or how severe they will be. Usually I can sleep and rest and can manage but this Summer they just cycle.

MRI ...
Read more : I hope they say MS.. Crazy? | Views : 277 | Replies : 7 | Forum : Undiagnosed


 

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