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Extension Study for Tovaxin

I had a request to ask about the extension study after the Phase IIb for Tovaxin. I don't remember who, but someone asked if we find out about our initial trial and whether or not we were getting the goods.

Everyone in the trial gets to participate in the extension. Everyone will find out if they were getting the drug or the placebo. I think that this is important to them as well. Anyway, I ...
Read more : Extension Study for Tovaxin | Views : 1948 | Replies : 4 | Forum : Tcelna (Tovaxin)


Minocycline & BBB effects

This may be old news to some, but its new to me. I had thought mino only worked due to its ant-inflamatory properties, but it also appears to reduce the BBB disruptions.

Minocycline Improves Neurological Outcome and Reduces BBB Disruption, Hemorrhage, and Perivascular Microglial Accumulation In Vivo
http://stroke.ahajournals.org/cgi/content/full/37/4/1087

A second agent that acts at the BBB is minocycline. Matrix metalloproteinases (MMPs) are produced during inflammation and contribute to the degradation of the basement membrane. This step ...
Read more : Minocycline & BBB effects | Views : 904 | Replies : 1 | Forum : General Discussion


New book: Next by Michael Crichton

I saw the Charlie Rose program yesterday in which he interviewed Michael Crichton about his new novel, Next. I have not read it, but it sounds good.

The author has an M.D. degree from Harvard and this book apparently deals with genetics; I have enjoyed several of his other books so I will look for this one, too.
Read more : New book: Next by Michael Crichton | Views : 3172 | Replies : 2 | Forum : Reading Nook


What I'd do differently

Hi All,

I wanted to put a few thoughts down, given what I have read on the other thread about a poor guy breaking up with his girlfriend, over MS and the very strong opinions being expressed by others. I'm not wanting to venture into anyone else's relationship but to just give my own views on the matter of being in a relationship when at least one party has MS. What I have to say ...
Read more : What I'd do differently | Views : 4726 | Replies : 18 | Forum : Daily Life


Prolactin

Just saw on the Canadian Global TV News network this evening an article about Prolactin and its apparent effect on pregnant MS patients.

These women produce Prolactin during pregnancy and they discovered that Prolactin rebuilds myelin in the brain lesions of the poor MS mouse. The researchers are likely going to spend two more years testing this on other animals and then depending what they discover, try it on humans.

Here is the link.

<shortened ...
Read more : Prolactin | Views : 2801 | Replies : 19 | Forum : General Discussion


new LDN study

Hello all,

I am a 4th year medical student who was diagnosed with MS about 5 years ago. I just came across this article which is about to be published in a high impact GI journal. In the interest of getting some legitimate MS/LDN trials going, it might not be a bad idea to get your hands on the article and give it to your neurologist. Does any of you see an MS specialist at ...
Read more : new LDN study | Views : 4860 | Replies : 6 | Forum : Low Dose Naltrexone


ABC News Primetime Interview

Hello all. I posted my intro in that forum but also wanted to post here to spread the word.

ABC News Primetime interviewed me for my story in fighting MS. It is hosted by Jay Schadler and should air sometime in the next couple months. The special is titled: Chronic Lyme Disease as it Pertains to ALS and MS. Two other patients were interviewed to my knowledge and one was Amy Tan (Author Joy Luck ...
Read more : ABC News Primetime Interview | Views : 1799 | Replies : 5 | Forum : General Discussion


New but have been around the block

Hello all. I live in CT, USA, and was diagnosed 5/4/06 with MS. My MS has not been labelled as I only had one episode just prior to diagnosis that made me bed ridden. I haven't had any further exacerbations/episodes. My doctors and I have treated this with high dose antibiotics and vitamin supplements for 10 months now. I did use Betaseron for 1.5 months and then quit as no advantage was found - only ...
Read more : New but have been around the block | Views : 2640 | Replies : 14 | Forum : Introductions


Fingolimod?

I'm debating a couple of trials to go for. Fingolimod seems the most promising, but the Copaxone/Steroid one seems likely. Has anyone done the clinical trial with Fingolimod? I'm interested, I'm kinda scared of Respritory Infections and all that Jazz. Please get back to me, very scared, confused and just plain sick of thinking about it.

Thanks!
Read more : Fingolimod? | Views : 1088 | Replies : 0 | Forum : General Discussion


Stearic Acid

A group of researchers in Shanghai seems to be doing a lot of research into the neuroprotective effects of stearic acid.



Neuroprotective effects of stearic acid against toxicity of oxygen/glucose deprivation or glutamate on rat cortical or hippocampal slices.

Acta Pharmacol Sin. 2006 Feb;27(2):145-50.
Wang ZJ, Li GM, Tang WL, Yin M.
School of Pharmacy, Shanghai Jiaotong University, Shanghai 200030, China. myin@sjtu.edu.cn

AIM: To observe the effects of stearic acid, ...
Read more : Stearic Acid | Views : 987 | Replies : 0 | Forum : General Discussion


 

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