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Depression

Depression and insomnia are 2 of the wonderful side effects of my MS. Last night i couldnt sleep, so i take a little ambien to get me down. . i get a good 8 (waking up once or twice) - ambien does give me a side effect of making me a little more grouchy and depressed (not as bad as if i didnt get any sleep - lesser of 2 evils). I need to shake ...
Read more : Depression | Views : 2461 | Replies : 13 | Forum : General Discussion


MS is not an immune system dysfunction, but disease of BBB?

If you don’t like conspiracy theories or half baked ideas, you can stop reading now, its long. However, if you enjoy to pick the threads from a poorly made suit, read on, I welcome the exchange.

Two points to start with:
1. Now, PRECEED EVERY SENTENCE WITH A "MAYBE", "POSSIBLY" or finish it with a "?" (as appropriate)
2. Read point 1 again.

* The BBB is in simple terms, the walls of capillaries http://www.daviddarling.info/encyclopedia/B/blood-brain_barrier.html ...
Read more : MS is not an immune system dysfunction, but disease of BBB? | Views : 3784 | Replies : 34 | Forum : General Discussion


Relevance of anti-myelin antibodies in MS (Rpt Post)

https://dare.ubvu.vu.nl/bitstream/1871/9249/1/Breij_dissertation.pdf

The title looks very interesting for people interested in Tovaxin. It also seemed generally applicable, so I also posted it under "General Discussion".
http://www.thisisms.com/ftopicp-23618.htm

I have yet to read it.
Read more : Relevance of anti-myelin antibodies in MS (Rpt Post) | Views : 1556 | Replies : 1 | Forum : Tcelna (Tovaxin)


Relevance of anti-myelin antibodies in Multiple Sclerosis

Woah, a big document with lots of pages (80 in english then 80 in flamish ie dutch)
https://dare.ubvu.vu.nl/bitstream/1871/9249/1/Breij_dissertation.pdf

I havent read it yet (its long) but it looks really interesting.

Houdoe en bedankt.
Read more : Relevance of anti-myelin antibodies in Multiple Sclerosis | Views : 941 | Replies : 1 | Forum : General Discussion


INCB8696

Not sure if this was posted before

Encouraging Early Study Results for Experimental CCR5 Antagonist INCB9471

At the JPMorgan Healthcare Conference earlier this month, Incyte Corporation announced promising preliminary data from a study of its investigational CCR5 antagonist candidate, INCB9471. The company also presented highlights of its ongoing drug development program, including agents to treat diabetes and cancer.
The following are edited excerpts from the company's January 8, 2007 press release:

New Incyte CCR5 Antagonist ...
Read more : INCB8696 | Views : 1218 | Replies : 0 | Forum : Drug Pipeline


1993 Kurtzke paper "Multiple Sclerosis as an Infection&

It seems to me that Dr Kurtzke has done more than anyone in generating and compiling MS data and trying to arrange it in a way as to make sense of a historically nonsensible situation.

Even though this paper is dated (1993) and the data used is even more dated, it seems to me that anyone affected with MS should take the time to read this one, if for no better reason than to gain ...
Read more : 1993 Kurtzke paper "Multiple Sclerosis as an Infection& | Views : 992 | Replies : 0 | Forum : General Discussion




DIGNAN! Anti-CD20

Dignan,

Instead of laying in bed with the lovely Jimmylegs this Saturday morning (lucky man!) there is some detective work that needs to be undertaken.

Rituxan (which depletes B cells and in my modest view shows real promise as an MS treatment (don't get scared off by the "it might kill you brigade" - we're all going to die of something)) is in trial for PPMS (Phase III) and RRMS (Phase II). Rituxan is a ...
Read more : DIGNAN! Anti-CD20 | Views : 1419 | Replies : 3 | Forum : Drug Pipeline


Genetics

Interesting genetics of MS study. I expect Bromley might have something to say about this as I think part of his personal team of world-leading neurologists is involved...



A second major histocompatibility complex susceptibility locus for multiple sclerosis.

Ann Neurol. 2007 Jan 24;
Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne ...
Read more : Genetics | Views : 1052 | Replies : 3 | Forum : General Discussion


TYsabri is back!

I am glad TYSABRI is back! I was on it once in January 2 years ago. I took my husband to NY for his 40th birthday in February and remember waking up that Saturday (2 weeks after my infusion) and turning to my husband and saying "I feel normal" I kept waiting for side effects and they never came. It was pulled off of the market right before my second treatment. I was bummed and ...
Read more : TYsabri is back! | Views : 1813 | Replies : 2 | Forum : Tysabri (Antegren or Natalizumab)


 

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