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Step towards understanding MS's variability

How often have we wondered why the course of MS varies so much from person to person, and why we respond so differently to various treatments? This new discovery might be a step towards understanding that:
Public release date: 13-Oct-2008


Contact: Amy Maxmen
amaxmen@rockefeller.edu
212-327-8393
Rockefeller University Press
Response to immune protein determines pathology of multiple sclerosis

New research ...
Read more : Step towards understanding MS's variability | Views : 1794 | Replies : 4 | Forum : General Discussion


Bionomics and Merck Serono

Bionomics, a small Australian company trying to develop Kv1.3 inhibitors, signed a development agreement with Merck Serono in June.


Merck Serono and Bionomics Announce Multiple Sclerosis Development and Licensing Agreement

June 19, 2008

- Bionomics and Merck Serono to collaborate to discover and develop novel, oral treatment for MS
- Collaboration based on novel compounds that allow selective inhibition of the immune cells which cause nerve cell damage in patients with MS

Geneva, Switzerland, 19 ...
Read more : Bionomics and Merck Serono | Views : 1572 | Replies : 2 | Forum : Drug Pipeline


Economic meltdown effects on MS treatments?

I have no idea, but i think it naive not to think the current climate will not have any effect on MS treatments. I am thinking people will be more restrained with investing in medical treatments in the pipeline that MAY turn out big later.
Read more : Economic meltdown effects on MS treatments? | Views : 1358 | Replies : 2 | Forum : General Discussion


Minocycline Promising for Fragile X Syndrome - autism, MMP-9

Forgive me if this is already covered -- I did search for "autism" in the Antibiotics forum and got zero results. So, this may be very interesting news...

UCR Researchers Propose Minocycline as a Promising Drug for Patients with Fragile X Syndrome

RIVERSIDE, Calif. – A UC Riverside-led team of biomedical scientists has found that a readily available drug called minocycline, used widely to treat acne and skin infections, can be used to treat Fragile ...
Read more : Minocycline Promising for Fragile X Syndrome - autism, MMP-9 | Views : 3258 | Replies : 9 | Forum : Antibiotics


3 month follow-up MRI

I got the results back from my 3 month follow-up MRI.

NO NEW LESIONS!!

NO ENHANCING LESIONS!!

And the report said "SLIGHT" improvement on previous lesions!!

I don't have the report in front of me (left it in friend's car)....but it wasn't bad news.

No lesions whatsoever on cervical or thoracic spine (had had C-spine MRI once...but never T spine).

I'm quite happy - as my last MRI had 2 new lesions...

Appt with my ...
Read more : 3 month follow-up MRI | Views : 1911 | Replies : 3 | Forum : Revimmune (cyclophosphamide or cytoxan)




Amitriptyline wearing off after only 6 wks....?

Hi all
had a nasty relapse about 7 weeks ago. Severe fatigue for 3 weeks, and a huge increase in neurological pain - you know the crawling, itching, pricking, nagging, gnawing horrible pain. It was all down my right side - just my right side - and I had twitching too so I wasn't sleeping.

The neurology clinic's nurse sent me a script for very low dose Amitriptyline (I think it's called Elavil in some ...
Read more : Amitriptyline wearing off after only 6 wks....? | Views : 1838 | Replies : 3 | Forum : General Discussion


New Tysabri patient

Well I'm switching from the Tovaxin thread to this thread now. Background: MS for 7 years. Avonex for first 4. Didn't really progress except in the area of side effects! They just kept getting worse and worse until I couldn't take it anymore. I felt pretty good though and was still very active; running every day, working alot, full social schedule. Then I got into the Tovaxin trial. I went downhill the whole time I ...
Read more : New Tysabri patient | Views : 3961 | Replies : 18 | Forum : Tysabri (Antegren or Natalizumab)


Interesting alliance

It sounds like Germany held a "BioPharma" competition to fund drug development. One of the winning groups, NeuroAllianz, is trying to develop therapeutics for neurodegenerative diseases.


Winning Consortium NeuroAllianz in the BioPharma Competition counts on UNIarray Technology

October 9, 2008 - Protagen AG, a leading provider of GMP compliant protein analytical services, protein bioinformatics, and protein biochips has won the BMBF’s BioPharma competition jointly with consortium “NeuroAllianz”. The twelve project partners will develop therapeutic as ...
Read more : Interesting alliance | Views : 1246 | Replies : 0 | Forum : General Discussion


Flupirtine

Flupirtine is an approved oral pain medication that is in phase 2 trials in MS. This is an interesting abstract.


Flupirtine as Neuroprotective Add-On Therapy in Autoimmune Optic Neuritis.

Am J Pathol. 2008 Oct 2.
Sättler MB, Williams SK, Neusch C, Otto M, Pehlke JR, Bähr M, Diem R.
From the Department of Neurology,* University of Göttingen, Göttingen; the Department of Neurology, University of Homburg/Saar, Homburg/Saar; and the Department of Neurology, University of Ulm, Ulm, ...
Read more : Flupirtine | Views : 1493 | Replies : 0 | Forum : Drug Pipeline


 

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