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Structural insight into the role of myelin basic protein...

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1450171
...This change in MBP conformation would free the epitope for T cell recognition and suggests a mechanism of action potentially initiated by alterations in myelin structure. This hypothesis is supported by a recent study describing antibody enzymes (abzymes) that catalyze MBP in a site-specific degradation (3). The C8 MBP isoform is also more abundant in immature myelin, and results of this study support the hypothesis that myelin structure in MS is developmentally immature (4), contributing ...
Read more : Structural insight into the role of myelin basic protein... | Views : 1171 | Replies : 0 | Forum : General Discussion




Therapies for MS

The UK MS Society has launched a new facility on its website about therapies such as LDN and Aimspro:

http://www.mssociety.org.uk/go.rm?id=21450
Read more : Therapies for MS | Views : 1896 | Replies : 8 | Forum : General Discussion


Private Messages

Is there a trick to getting you PM's to go? I've had one in my outbox for about 24 hours. Do I need to log out?
Read more : Private Messages | Views : 1441 | Replies : 5 | Forum : General Discussion


An interesting article about depression

I always felt my husband's depression was caused directly by his illness rather than because he felt bad because he knew he was ill...if you know what I mean:
http://www.boston.com/news/science/arti ... sed_brain/
Read more : An interesting article about depression | Views : 1231 | Replies : 2 | Forum : General Discussion


Music...

I'm kinda reticent to do this, because I'm sensitive to everyone's varying levels of ability/disability and in general, I'm a bit wary of making proclamations... but I had a mini revelation this week...

We had a good report from my husband's neurologist. She's pleased with his lack of exacerbations or attacks since his dx last March. In trying to understand why his function is so high, especially with his high lesion load (over 20 on ...
Read more : Music... | Views : 1534 | Replies : 6 | Forum : General Discussion


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Read more : . | Views : 1787 | Replies : 1 | Forum : Revimmune (cyclophosphamide or cytoxan)


Upcoming research conferences

For nerds like me who are interested in such things, two research conferences at the end of the month:


The Charcot Foundation symposium is in Italy.

http://www.charcot-ms.eu/main.php?pag=p ... 8&sid2=128


Conference on B cells and MS which takes place in California.

http://www.biosymposia.org/content25262.html


Presentations on Rituximab seem to be common to both. I'll post any interesting stuff if I see it.

Ian
Read more : Upcoming research conferences | Views : 1589 | Replies : 1 | Forum : General Discussion


Another stem cell trial

This stem cell trial is a new one to me.



Donor Stem Cell Transplantation for the Treatment of Multiple Sclerosis

This study is currently recruiting participants.
Verified by University of Louisville, July 2007
Phase I / II

Purpose
While the cause of MS in not known, there is an autoimmune component that destroys nerve cells. Autoimmunity is a condition where an individual's immune system attacks his/her own cells. Bone marrow stem cell transplantation has been ...
Read more : Another stem cell trial | Views : 1821 | Replies : 0 | Forum : Stem Cells


MS, Tysabri, and the low risk of PML...

Hi everyone,

I have some information I would like to pass on to those here that are contemplating Tysabri therapy from a treating neurologist friend of mine regarding Tysabri and possible rare risk of PML (some of his patients are on Tysabri, and some of them are on the older generation ABCRs). Take good care now...Lauren :)

Without becoming too long-winded or using too many medical terms, ...
Read more : MS, Tysabri, and the low risk of PML... | Views : 4507 | Replies : 14 | Forum : Tysabri (Antegren or Natalizumab)


 

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