This abstract provides a rationale for the use of, among other things, niacin and nicotinamide:
Pharmacological Targeting of IDO-Mediated Tolerance for Treating Autoimmune Disease.
University of Cincinnati, Building C Room 217A, 2180 E. Galbraith Road, Cincinnati, OH 45237, USA. WTPENBER@YAHOO.COM
Immunomodulatory factors including IFNgamma, TNFalpha, IL-1, and LPS use IDO induction in responsive antigen presenting cells (APCs) also to transmit tolerogenic signals to T cells. Thus it makes ...