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Chromos reports preclinical data in support of CHR-1103 as an acute therapy for relapse associated with multiple sclerosis
Brain Pathology paper has implications for treatment of MS.

Chromos Molecular Systems Inc. announced today the publication of a paper entitled "Modulation of Experimental Autoimmune Encephalomyelitis by VLA-2 Blockade" in the peer-reviewed scientific journal, Brain Pathology. This paper, authored in collaboration with Dr. Robert Fujinami of the University of Utah School of Medicine, demonstrates that a monoclonal ...
Read more : CHR-1103 | Views : 1336 | Replies : 3 | Forum : Drug Pipeline

Antibodies to myelin

Antibodies to Myelin Don't Signal MS

By Neil Osterweil, Senior Associate Editor, MedPage Today
Reviewed by Rubeen K. Israni, M.D., Fellow, Renal-Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine
January 24, 2007

Basel, Switzerland, Jan. 24 -- Contrary to a previous report, the presence in the blood of two types of antibodies to myelin is not diagnostic of multiple sclerosis, investigators here reported.

Nor does the presence of the antibodies indicate a risk ...
Read more : Antibodies to myelin | Views : 4390 | Replies : 39 | Forum : General Discussion

RTL 1000

Artielle ImmunoTherapeutics, Inc., and QSV Biologics, Ltd. Sign Contract for cGMP Manufacture of RTL 1000 for Multiple Sclerosis
22 Jan 2007
Announced today the signing of a contract for the process development and cGMP manufacturing of RTL 1000 for multiple sclerosis.

EDMONTON, Canada | Jan 22, 2007 | QSV Biologics, Ltd (QSV), a North American based biologics CMO located in Edmonton, Canada, and Artielle ImmunoTherapeutics, Inc., (Artielle) a privately held autoimmune therapeutics company located in ...
Read more : RTL 1000 | Views : 1609 | Replies : 0 | Forum : Drug Pipeline

Bone Marrow Stem Cells

Stem Cells Cultured From Human Bone Marrow Behave Like Those Derived From Brain Tissue

Stem cells taken from adult human bone marrow have been manipulated by scientists at the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center to generate aggregates of cells called spheres that are similar to those derived from neural stem cells of the brain.
In addition, the bone marrow-derived stem cells, which could be differentiated into neurons and other cells making ...
Read more : Bone Marrow Stem Cells | Views : 1243 | Replies : 0 | Forum : Stem Cells

Dating Challenges

hello to all,

while i've posted a few comments, i've probably been more of an observer...i've read a lot of poignant and touching comments by many members and thought i would vent a little bit. i am a thirty-something year old guy who had one significnat attack about 2 years ago. i was pretty sick for about a year, but eventyually slowly recovered. these days, i've been pretty fortunate in that i only have a ...
Read more : Dating Challenges | Views : 1405 | Replies : 4 | Forum : General Discussion

St Jude study

Chopping Off Protein Puts Immune Cells Into High Gear

St. Jude study shows LAG-3 protein on activated T lymphocytes slows replication until ADAM10 and ADAM17 enzymes cleave it off to allow these cells to reproduce rapidly

MEMPHIS, Tenn., Jan. 24 /PRNewswire/ -- The complex task of launching a well-organized, effective immune system attack on specific targets is thrown into high gear when either of two specific enzymes chop a protein called LAG-3 off the immune ...
Read more : St Jude study | Views : 802 | Replies : 0 | Forum : General Discussion

Minocycline Scores for Neuroprotection

A positive study on minocycline and neuroprotection 8)

Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation
Available therapies mainly target the inflammatory component of the disease but fail to prevent neurodegeneration.

Functional and histopathological data of RGCs and optic nerves revealed neuronal and axonal protection when minocycline treatment was started on the day of immunization.

Furthermore, we demonstrate that minocycline-induced neuroprotection is related to a ...
Read more : Minocycline Scores for Neuroprotection | Views : 1558 | Replies : 5 | Forum : Drug Pipeline

neat serotonin info

Serotonin deficiency
Serotonin deficiency signs/symptoms:
Nervous/worrier/can’t relax
Obsessive compulsive tendency
Self destructive or suicidal thoughts/plans
Low self esteem/confidence
Sleep problems/light sleeper
Feel worse in & dislike dark weather
Crave sugar/carbs/salt/alcohol/marijuana
-These substances relax you
Chronic pain (e.g. headaches, backaches, fibomyalgia)
Antidepressants or 5-HTP improve mood
Serotonin levels may be low due to a combination of genetic and acquired reasons. Serotonin can be raised effectively using either nutrient based ...
Read more : neat serotonin info | Views : 952 | Replies : 2 | Forum : General Discussion

Tysabri infused in Canada

I was talking to the Biogen/Tysabri toll-free help line yesterday and Monday and according to them the first two Tysabri infusions were to take place today in the northern Ontario (central Canada) city of Sudbury (2001 population - approximately 155,000).

So it looks like Tysabri has arrived in Canada. :)

Any Canadians out there who have been infused could you please share your experiences.

From the sunny ...
Read more : Tysabri infused in Canada | Views : 1997 | Replies : 2 | Forum : Tysabri (Antegren or Natalizumab)


I am new to the board and MS (diagnosed 11/16/06 within 2wks of my 1st symptom), my question is who do you tell you have MS and when. I have made some logical judgement calls (Immediate family.In-laws, anyone who may have to take care of my son (2 1/2) - Daycare, emergency pick up people, all of my physicians), but am unsure from there. A cousin of mine has MS. He is a second cousin ...
Read more : Disclosure | Views : 1433 | Replies : 8 | Forum : General Discussion


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