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Cochrane review of cyclophosphamide

I guess this validates cytoxan not being approved as an MS therapy.



Cyclophosphamide for multiple sclerosis.

Cochrane Database Syst Rev. 2007 Jan 24;(1):CD002819.
La Mantia L, Milanese C, Mascoli N, D'Amico R, Weinstock-Guttman B.

BACKGROUND: Multiple sclerosis is a presumed cell-mediated autoimmune disease of the central nervous system. Cyclophosphamide (CFX) is a cytotoxic and immunosuppressive agent, used in systemic autoimmune diseases. Controversial results have been reported on its efficacy in MS. We conducted a systematic ...
Read more : Cochrane review of cyclophosphamide | Views : 1465 | Replies : 3 | Forum : Drug Pipeline


B cells

Edmond scientist discovers hidden antibodies in mice

A discovery by an Oklahoma Medical Research scientist has discredited the 50-year-old accepted dogma that disease fighting cells in the body carry only one protein.

Edmond’s Patrick Wilson has discovered that B cells can make a mistake when the cells bind to human tissue and change receptors. Cells changing receptors sometimes may result in a second allele (chromosome) producing a second antibody protein, he found. Wilson revealed ...
Read more : B cells | Views : 878 | Replies : 1 | Forum : General Discussion


One problem with the "golden years"...

One problem with the so-called golden years is that just as you are starting to need more help yourself, the family who might have been there to help when you were younger are now needing help themselves--and dying off.

So you find yourself becoming more and more isolated. You can't replace your family. You'll never have another, probably. When they're gone, they're gone.

All of my siblings were old enough to have been another generation. ...
Read more : One problem with the "golden years"... | Views : 3972 | Replies : 7 | Forum : MS in the Golden Years


Pen Again Ergonomic Pen

Pen Again ergonomic pen.
I had one of these new pen bought for me, as using normal, thin biro's and pens aint so easy for me anymore. The pen is great, comfortable to write with and easy to write with despite my numb, pins and needles fingers.
The is a (U.S) website:

www.penagain.com

A google search will show you where you can get them locally (I am in Melbourne, ...
Read more : Pen Again Ergonomic Pen | Views : 2970 | Replies : 0 | Forum : Shopping


Immune System Brakes

Immune system 'brakes' found

Scientists say they have learnt how the body controls the machinery it uses to fight infections and foreign invaders.

The advance, published in the journal Nature, may one day help find ways to tackle unwanted immune reactions following transplant surgery.

The Johns Hopkins University researchers say a protein molecule called carabin may be the body's way of restraining its defences.

The US-based team describes it as a 'built-in timer' for ...
Read more : Immune System Brakes | Views : 1053 | Replies : 2 | Forum : General Discussion


Depression

Depression and insomnia are 2 of the wonderful side effects of my MS. Last night i couldnt sleep, so i take a little ambien to get me down. . i get a good 8 (waking up once or twice) - ambien does give me a side effect of making me a little more grouchy and depressed (not as bad as if i didnt get any sleep - lesser of 2 evils). I need to shake ...
Read more : Depression | Views : 2493 | Replies : 13 | Forum : General Discussion


MS is not an immune system dysfunction, but disease of BBB?

If you don’t like conspiracy theories or half baked ideas, you can stop reading now, its long. However, if you enjoy to pick the threads from a poorly made suit, read on, I welcome the exchange.

Two points to start with:
1. Now, PRECEED EVERY SENTENCE WITH A "MAYBE", "POSSIBLY" or finish it with a "?" (as appropriate)
2. Read point 1 again.

* The BBB is in simple terms, the walls of capillaries http://www.daviddarling.info/encyclopedia/B/blood-brain_barrier.html ...
Read more : MS is not an immune system dysfunction, but disease of BBB? | Views : 3981 | Replies : 34 | Forum : General Discussion


Relevance of anti-myelin antibodies in MS (Rpt Post)

https://dare.ubvu.vu.nl/bitstream/1871/9249/1/Breij_dissertation.pdf

The title looks very interesting for people interested in Tovaxin. It also seemed generally applicable, so I also posted it under "General Discussion".
http://www.thisisms.com/ftopicp-23618.htm

I have yet to read it.
Read more : Relevance of anti-myelin antibodies in MS (Rpt Post) | Views : 1571 | Replies : 1 | Forum : Tcelna (Tovaxin)


Relevance of anti-myelin antibodies in Multiple Sclerosis

Woah, a big document with lots of pages (80 in english then 80 in flamish ie dutch)
https://dare.ubvu.vu.nl/bitstream/1871/9249/1/Breij_dissertation.pdf

I havent read it yet (its long) but it looks really interesting.

Houdoe en bedankt.
Read more : Relevance of anti-myelin antibodies in Multiple Sclerosis | Views : 984 | Replies : 1 | Forum : General Discussion


INCB8696

Not sure if this was posted before

Encouraging Early Study Results for Experimental CCR5 Antagonist INCB9471

At the JPMorgan Healthcare Conference earlier this month, Incyte Corporation announced promising preliminary data from a study of its investigational CCR5 antagonist candidate, INCB9471. The company also presented highlights of its ongoing drug development program, including agents to treat diabetes and cancer.
The following are edited excerpts from the company's January 8, 2007 press release:

New Incyte CCR5 Antagonist ...
Read more : INCB8696 | Views : 1235 | Replies : 0 | Forum : Drug Pipeline


 

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