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Ocrelizumab

Ocrelizumab is a new anti-CD20 drug that is being called a second-generation rituxan. Genentech and Biogen are collaborating on it and it is supposed to be entering trials for MS very soon. Genentech wants to start it right at phase 3(!!!) later this year, but the two companies are in arbitration because they disagree on how to proceed (see bolded section below). I will put it on the list when we hear about the results ...
Read more : Ocrelizumab | Views : 5306 | Replies : 2 | Forum : Drug Pipeline


My new friend, Tamiflu.

Hi, I didn't want to post this at the end of my own regimen, where it may be lost.

I have had MS symptoms for over ten years. In that 10ys I cannot remember any time where a relapse was not preceded by a cold or flu. They appear to be my only trigger for a relapse. Anyway, I recently got a script for an anti-viral called Tamiflu, in preparation for my next infection. Well, ...
Read more : My new friend, Tamiflu. | Views : 4741 | Replies : 1 | Forum : Regimens


The Return Of The Astrocytes!

No, it's not a cheap science fiction film: it's the revival of a long forgotten suggestion that these cells may have an important role to play in MS, as agents of both damage and repair:

Astrocytes-Friends or foes in multiple sclerosis?

Williams A, Piaton G, Lubetzki C.

Inserm, U711, Université Pierre and Marie Curie, Faculté de médecine, IFR 70, Paris F‐75013, France.

In multiple sclerosis (MS), the presence of demyelinating plaques has concentrated researchers' minds ...
Read more : The Return Of The Astrocytes! | Views : 1429 | Replies : 7 | Forum : General Discussion


muscle stiffness?

Has anybody experienced muscle stiffness as a side effect of Copaxone?
Read more : muscle stiffness? | Views : 2888 | Replies : 5 | Forum : Copaxone


Passing (hosting) files in forums

Came across the following site. We all now know of photobucket for pics, but this site allows you to pass (host) all other types of files, for free.

http://www.sendspace.com/

I'm sure there is more than one, or better, but I stumbled across this one, and thought I'd share.
Read more : Passing (hosting) files in forums | Views : 2577 | Replies : 1 | Forum : Site Support


Parasitic worms and inflammatory diseases

Despite the fact that it must infuriate Ian, Cambridge is also one of the leading research centers investigating the relationship between the loss of evolutionary normal conditions and the subsequent rise in incidence of inflammatory diseases.
Bob

Full access to the article: http://tinyurl.com/388em3
Read more : Parasitic worms and inflammatory diseases | Views : 1128 | Replies : 2 | Forum : General Discussion


MS symptoms by AGE


I was clinically diagnosed with MS in January 2007.
However, for the past few years it was considered "possible MS".

I've had random symptoms for years, ever since i can remember - but never would I have thought it was MS because I did not know anything about it.

So now I have it - and am being treated with various medications - AVONEX specifically for MS.

What I really want to know is - ...
Read more : MS symptoms by AGE | Views : 1894 | Replies : 6 | Forum : General Discussion


EGFR and remyelination

Discovery Of Brain Protein Has Major Implications For Repairing Brain Damage In Newborns
11 Jul 2007 - 2:00 PDT

Scientists at Children's National Medical Center have demonstrated conclusively that a specific protein and its signaling activity are instrumental in myelination and remyelination, processes essential to the creation and repair of the brain's white matter. This groundbreaking discovery in mouse models points the way to developing treatments or interventions to enhance healthy brain development and/or brain ...
Read more : EGFR and remyelination | Views : 866 | Replies : 0 | Forum : General Discussion


Complementary supplements IFN-beta

MMP-9s KILL the activity of ALL IFN-Betas.

It is a VERY GOOD IDEA to lower MMP-9s if taking an Ifn-Beta drug.

If you want to maximize Avonex (or any beta interferon), lowering MMP-9s will prevent it from being degraded by being cleaved into parts thus killing its Activity/Effectiveness.

http://www.cnsforum.com/commenteditem/f ... fault.aspx


Also getting the most activity from the least amount of near natural (human) interferon like Avonex will usually ...
Read more : Complementary supplements IFN-beta | Views : 1640 | Replies : 0 | Forum : Natural Approach


Which T cell types drive the autoimmune response?

Although the focus of their research sounds interesting it's a little bothersome that their photo subject of MS is in a wheelchair and the photo labeled "Multiple sclerosis".

Not that people with MS don't end up in wheel chairs but it's not as inevitable as their use of the picture makes it seem.
http://www.spiritindia.com/health-care- ... 11391.html
Bob
Read more : Which T cell types drive the autoimmune response? | Views : 996 | Replies : 0 | Forum : General Discussion


 

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