Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia.
Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX.
Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
IL-12 has long been considered important in the pathogenesis of multiple sclerosis. However, evidence from recent studies strongly supports the critical role of IL-12-related proinflammatory cytokine IL-23, but not IL-12, in the development of experimental autoimmune encephalomyelitis (EAE), an animal model ...