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I had always wondered about the fatigue. Here is a pretty good article explaining MS related fatigue.
Read more : Fatigue | Views : 1628 | Replies : 2 | Forum : General Discussion

Estrogen Neuroprotective (Mice)

An abstract from the recent AAN meeting reported an estrogen ligand was neuroprotective in mice and the effect was not attributable to anti-inflammatory properties in the peripheral immune system.
Differential Effects of Estrogen Receptor (ER)α Versus ERβ Ligand Treatment: Anti-Inflammatory Versus Directly Neuroprotective

Seema K. Tiwari-Woodruff, Laurie-Beth J. Morales, Ruri Lee, Los Angeles, Rhonda Voskuhl, Los Angeles, CA
RESULTS: While ERα ligand treatment was anti-inflammatory, ERβ ligand treatment was not. ERβ ligand treatment ...
Read more : Estrogen Neuroprotective (Mice) | Views : 1366 | Replies : 0 | Forum : Drug Pipeline

Recording of Harvard MS

You can find a very interesting video-presentation from the Harvard MS conference, here:
Link to the presentation

Just click on the small film icons on the left side to watch the videos.

Read more : Recording of Harvard MS | Views : 1104 | Replies : 1 | Forum : General Discussion

Vitamin D casts cancer prevention in new light

Vitamin D casts cancer prevention in new light
From Saturday's Globe and Mail
April 28, 2007 at 1:20 AM EDT

For decades, researchers have puzzled over why rich northern countries have cancer rates many times higher than those in developing countries — and many have laid the blame on dangerous pollutants spewed out by industry.
But research into vitamin D is suggesting both a plausible answer to this medical puzzle and a heretical ...
Read more : Vitamin D casts cancer prevention in new light | Views : 987 | Replies : 1 | Forum : General Discussion

How would ?

How would my wifes life be different without me? I am at a point where i can't stop thinking how i am changing my wifes life. Without me it would be so much better for her, she says no but i know in my heart that i am holding her down, i just mean little things like going out ,dancing, travelling, shopping ect. I could still do this stuff but not the way it ...
Read more : How would ? | Views : 4777 | Replies : 20 | Forum : Daily Life


...I e mailed David last week for a new prescription, can you check he received it?


Alan Lafferty
Read more : Sarah... | Views : 1945 | Replies : 5 | Forum : Antibiotics

Cancer, MS and vitamin D

Cancer, MS and Vitamin D

With respect to vitamin D, I believe the MS community is a microcosm of the cancer realm. Prior to this past week, there existed many statistical analyses and observational studies which demonstrated a strong link between vitamin D deficiency and cancer prevalence.

Of course there were the obvious questions about the role of vitamin D as far as cancer prevention and active cancer therapy. The necessary dosage and toxicity were ...
Read more : Cancer, MS and vitamin D | Views : 1015 | Replies : 0 | Forum : General Discussion

More FTY720 Info

Came up on Google this afternoon...


Preclinical Studies Suggest FTY720 Mechanisms In Multiple Sclerosis May Include Direct Activity In The Brain

New preclinical data, presented at the American Academy of Neurology (AAN) annual meeting in Boston, reflect the expanding understanding of FTY720's (fingolimod) mechanism of action in multiple sclerosis (MS), suggesting direct beneficial effects in the brain. The data suggest that FTY720 may have the potential to reduce neurodegeneration and enhance repair of the ...
Read more : More FTY720 Info | Views : 1436 | Replies : 3 | Forum : Drug Pipeline

Naive B cells and IL-10

Cytokines are the molecules which cells use to communicate with each other. Some of them, like IL-10, turn down inflammation, while others turn it up. In MS the levels of these molecules are out of balance, with too little IL-10 being produced.
It seems that IL-10 is normally made by "naive" B cells, which are "blank" cells that haven't been exposed to enemy tissue, while the inflammatory cytokines are made by "memory" B cells, which ...
Read more : Naive B cells and IL-10 | Views : 1040 | Replies : 2 | Forum : General Discussion

My Tysabri Story

I finally got to see a Specialist (only a 4 month wait) and she was great. After viewing my MRI (I had over 25 leisions in my brain area), she was concerned that I was being treated solely with Copaxone (on for approx 6 months), and immediately ordered another MRI.

Good news - some of the leisions went away completely (no scarring), Bad news - but many more appeared (over 30 at her current count). ...
Read more : My Tysabri Story | Views : 3698 | Replies : 10 | Forum : Tysabri (Antegren or Natalizumab)


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