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Xanthus Pharmaceuticals, Inc. presented preclinical results from the Company’s FLT3 autoimmune program that describe a novel mechanism of action for achieving prolonged disease attenuation in an animal model for multiple sclerosis (MS). The experiments showed that Symadex™, the lead compound from Xanthus’ FLT3 autoimmune program, directly targets macrophages and monocytes, key cells responsible for driving the autoimmune response. Stephen J. Karlik, Ph.D., Professor of Diagnostic Radiology at the University of Western Ontario, London, Ontario, described ...
Read more : Symadex | Views : 1387 | Replies : 0 | Forum : Drug Pipeline

Possible new role for blood in the brain

This seems like a bizarre idea and a completely different view on how the brain might work, but a new twist in thinking might be just what we need:

Public release date: 15-Oct-2007

Contact: Elizabeth Thomson
Massachusetts Institute of Technology
MIT: blood may help us think
CAMBRIDGE, Mass.--MIT scientists propose that blood may help us think, in addition ...
Read more : Possible new role for blood in the brain | Views : 1789 | Replies : 1 | Forum : General Discussion

Histone deacetylase (HDAC) inhibitors stimulate T-reg Cells

Cancer drugs could fight autoimmune disease

* 16 October 2007
* news service

Many anti-cancer drugs have the unfortunate side-effect of depressing the body's immune system. So it makes sense that one class of these drugs is being investigated as a way of tackling autoimmune diseases like multiple sclerosis and rheumatoid arthritis. These are triggered when the immune system's T-cells go into overdrive and attack the body's own cells.

Wayne Hancock and colleagues at ...
Read more : Histone deacetylase (HDAC) inhibitors stimulate T-reg Cells | Views : 1401 | Replies : 0 | Forum : Drug Pipeline

Biogen is up for sale

Here's some recent news on Biogen. Apparently, their board of directors is considering putting the company up for sale.

Biogen's management gets OK to consider sale

Biogen IDEC Issues Statement

Read more : Biogen is up for sale | Views : 1543 | Replies : 0 | Forum : General Discussion

New here

My name is Lauri and I was diagnosed with MS in 2004. I started on Avonex and loved it but unfortunately had to switch to Rebif. I have gone on disability in the last year.

Lauri xo
Read more : New here | Views : 1669 | Replies : 4 | Forum : Introductions

ECTRIMS report

A post-hoc analysis from a Phase III clinical trial of AVONEX(R) (interferon beta-1a) and post-randomization eight-year follow up shows that six-month sustained progression of disability at two years, using the Expanded Disability Status Scale (EDSS), is a significant predictor of long-term disability, as measured by EDSS milestones of 4.0, 5.0, 6.0 and 7.0 at eight years, in patients with relapsing-remitting multiple sclerosis (RRMS).

The analysis suggests that patients taking AVONEX for two years were less ...
Read more : ECTRIMS report | Views : 2316 | Replies : 2 | Forum : Avonex

Gene variants linked to MS

Three gene variants have been found to correlate with susceptibility to multiple sclerosis, according to findings of the International Multiple Sclerosis Genetics Consortium (IMSGC) presented here at the 132nd Annual Meeting of the American Neurological Association (ANA).

Variants of interleukin 2RA, interleukin 7RA and CD58 were found to correlate with multiple sclerosis in a whole genome analysis that included about 4,500 participants. "The same finding has been reported in two other papers as well," noted ...
Read more : Gene variants linked to MS | Views : 1860 | Replies : 7 | Forum : General Discussion

Disease-free on Tysabri?

12 October 2007, 14:57:35
Study Shows Increased Proportion of Patients Achieve Disease-Free Status with TYSABRI - Separate Study Demonstrates Plasma Exchange May Be an Effective Tool to Accelerate TYSABRI Removal.

Biogen Idec and Elan Corporation, plc announced that TYSABRI® (natalizumab) treatment significantly increases the proportion of disease-free patients with multiple sclerosis (MS) according to a post hoc analysis of the Phase III AFFIRM study to be presented on Saturday, October 13, 2007 at the 23rd ...
Read more : Disease-free on Tysabri? | Views : 12163 | Replies : 42 | Forum : Tysabri (Antegren or Natalizumab)

Endocannabinnoids and neuroprotection

There's quite a lot of general background information here, but the upshot of it all seems to be that the neuroprotective effects are useful in diseases like MS:

Public release date: 14-Oct-2007

Contact: Professor Raphael Mechoulam
European College of Neuropsychopharmacology

The endocannabinoids: Functional roles and therapeutic opportunities
Cannabis (marijuana) is the most widely produced plant-based illicit drug worldwide and ...
Read more : Endocannabinnoids and neuroprotection | Views : 1294 | Replies : 0 | Forum : General Discussion


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