I'm afraid to note that in my experience and from research on pubmed, it seems very likely that over-indulgence with alcohol will negatively impact the vasculature by causing excessive endothelin 1 reactivity.
1: J Pharmacol Exp Ther. 2006 Aug;318(2):819-27. Epub 2006 May 1. Links
Ethanol consumption enhances endothelin-1-induced contraction in the isolated rat carotid.Tirapelli CR, Casolari DA, Montezano AC, Yogi A, Tostes RC, Legros E, D'Orléans-Juste P, Lanchote VL, Uyemura SA, de Oliveira AM.