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Therapy Yields Promise for Fatal Neurological Condition

http://www.washingtonpost.com/wp-dyn/content/article/2008/05/13/AR2008051301592.html

In a clinical trial, reported on in the May 13 online issue of Human Gene Therapy, neurological surgeons created six tiny holes in the skull of a patient, and then injected into the brain a liquid containing the healthy CLN2 gene within the harmless adeno-associated virus (AAV).

"The virus is used as a Trojan horse that houses and then delivers a healthy, functional gene into the cells of the brain," Crystal said. "The genes ...
Read more : Therapy Yields Promise for Fatal Neurological Condition | Views : 3067 | Replies : 0 | Forum : Gene Therapy


Introducing...

..the one and only Cyclops!

Hi everyone. I'm new. I chose the name Cyclops as that's how I feel right now. I was diagnosed 6 months ago after getting a dose of optic neuritis which still hasn't cleared up. I've been reading your posts and following your stories and felt it was about time I joined the club.

One-eyed smiley - like it?

.-)
Read more : Introducing... | Views : 1797 | Replies : 5 | Forum : Introductions


Future of MS Research talk

On Monday evening, Professor Robin Franklin (one of the top MS researchers in the UK) gave a presentation on the future of MS research. I didn't attend, but an attendee posted this summary on the UK MS Society website. Thought it may be of interest.

Ian

The Future of MS (MSS talk 12 May 2008)

This was an excellent talk last night by Professor Robin Franklin from the Cambridge Myelin Repair Project whose team works ...
Read more : Future of MS Research talk | Views : 1692 | Replies : 0 | Forum : General Discussion


Interferon and stem cells

It's what we've all been dreaming of: a way to combine one of the most promising future MS treatments with the crap we're currently stuck with!


Stem cell based delivery of IFN-beta reduces relapses in experimental autoimmune encephalomyelitis.

J Neuroimmunol. 2008 May 7
Makar TK, Trisler D, Bever CT, Goolsby JE, Sura KT, Balasubramanian S, Sultana S, Patel N, Ford D, Singh IS, Gupta A, Valenzuela RM, Dhib-Jalbut S.
VA Maryland Healthcare System, Baltimore, MD ...
Read more : Interferon and stem cells | Views : 1650 | Replies : 0 | Forum : Stem Cells


Experience Project

Interesting...so Arron = Armen Berjikly?


Experience Project reaches a million user posts in a year, raises $3 million

May 13th, 2008 - Experience Project has quietly drawn a big community of people who share life experiences with each other anonymously. Since it started a little more than a year ago, users have created a million distinct experiences on intimate subjects such as “I live in a sexless marriage.” The company has raised $3 million in ...
Read more : Experience Project | Views : 2309 | Replies : 5 | Forum : General Discussion


Warning- tetracyclines + headache

Jeff has a monster migraine (first one) throbbing temples. I'm hoping it's not from mino causing intracranial hypertension. Will check with neuro tomorrow. His vision is OK, (and he's not an obese woman), but he says he's never had a headache like this one. May be at ER before the night is out-
send good thoughts, please
AC

http://bmj.bmjjournals.com/cgi/content/ ... 0/613?etoc
Read more : Warning- tetracyclines + headache | Views : 3574 | Replies : 13 | Forum : Antibiotics


Headaches

Haven't had one like this in a long time. In fact, I can't recall if I have had one quite like this.

I started my Copaxone 3 days ago (3rd injection today). I'm also taking tetracycline for an acne issue.

Woke up with a bit of a headache, that never went away after taking 2 extra strength Tylenol. Due to various reasons, I couldn't just roll over and go back to sleep. I also got ...
Read more : Headaches | Views : 4960 | Replies : 41 | Forum : General Discussion


Anti-inflammation drugs - preclinical and phase 1/2

Both of these could benefit MS down the line.

Modulation of RNA Splicing Focuses on Inflammatory Diseases, Including Rheumatoid Arthritis

In this study, treatment with LNA oligonucleotides, developed by Santaris, induced alternative RNA splicing of TNF receptor 2, resulting in a switch from the membrane-bound to a soluble protein form, thus creating a "decoy" receptor, which accumulated in the circulation of treated mice. The generated soluble TNF receptor protein antagonized TNF-alpha, interfered with its inflammatory ...
Read more : Anti-inflammation drugs - preclinical and phase 1/2 | Views : 1483 | Replies : 0 | Forum : Drug Pipeline


When is Sciatica NOT Sciatica!

Hi guys,

I've got ( what I think is ) Sciatica. Had it bad 4 years ago and got acupuncture. Disappeared.

Now I've done the ON thing and got an MRI result with three spots and....the Sciatica which had started to twinge really went for it last night :cry:

would appreciate your sciatica stories and if it might be MS symptoms instead. Woke up ...
Read more : When is Sciatica NOT Sciatica! | Views : 10789 | Replies : 8 | Forum : General Discussion


An alternative to steroids?

Hi. I'm wondering if anyone has had experiences with treatments other than steroids for relapses. My girlfriend has MS. She recently started physical therapy and is having problems with leg numbness during the therapy. It's like the PT is making her worse rather than better. She's been on prednisone previously but doesn't want to go back on it. Have any of you used other medications/preparations with success in treating the inflammatory symptoms? I've started reading ...
Read more : An alternative to steroids? | Views : 2842 | Replies : 10 | Forum : General Discussion


 

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