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Homocysteine decreases cerebral perfusion

I think that any discussion of endothelial health and cerebral perfusion is incomplete without considering homocysteine.

Resting brain perfusion and selected vascular risk factors in healthy elderly subjects.
PLoS One. 2014 May 19;9(5):e97363.

    BACKGROUND AND PURPOSE: Both cerebral hypoperfusion and vascular risk factors have been implicated in early aging of the brain and the development of neurodegenerative disease. However, the current knowledge of the importance of cardiovascular health on resting brain perfusion is limited. The ...


Alzheimer Nitric Oxide NOS2

Abstract:
Understanding the pathophysiologic mechanisms underlying Alzheimer disease relies on knowledge of disease onset and the sequence of development of brain pathologies. We present a comprehensive analysis of early and progressive changes in a mouse model that demonstrates a full spectrum of characteristic Alzheimer disease–like pathologies. This model demonstrates an altered immune redox state reminiscent of the human disease and capitalizes on data indicating critical differences between human and mouse immune responses, particularly in nitric ...
Read more : Alzheimer Nitric Oxide NOS2 | Views : 210 | Replies : 1 | Forum : Chronic Cerebrospinal Venous Insufficiency (CCSVI)


"in our sameness we are all so different" LIKE A FINGERPRINT

I've always said we are individuals and dr.'s needed to listen to us as such, check us out every way possible etc. NOT give us a diag. that is still to this day based on an "auto immune "theory" only"! that we carry from that day forth like a monkey on your back- just so they can justify almost everything going on is because ya got these symptoms somebody decided to name ms. "forget that ...
Read more : "in our sameness we are all so different" LIKE A FINGERPRINT | Views : 171 | Replies : 0 | Forum : General Discussion


MS B12 Pacemaker

My docs tell me they are convinced that I have ms. I've had the symptoms for years but wrote them off to side effects from meds. When I went over the list of symptoms with my doctors--finally--saying "I am spiraling downward," and they observed my spasms, trembling, and then the double vision...well, you all know the story. I can't play my piano anymore.

But I'm not convinced entirely. I can't do an MRI because of ...
Read more : MS B12 Pacemaker | Views : 324 | Replies : 14 | Forum : General Discussion


I hope they say MS.. Crazy?

Once was a healthy person never seeing Dr..For the last few years have seen several: PCP, Rheumy, Orthoped and now Neurologist. UGH!

Numbness, weakness, tingling, itching, vertigo, fatigue, rib cramps and now this vibration like a tuning fork. All of these come and go. I never now how long the symptoms will last or how severe they will be. Usually I can sleep and rest and can manage but this Summer they just cycle.

MRI ...
Read more : I hope they say MS.. Crazy? | Views : 316 | Replies : 7 | Forum : Undiagnosed


Been suffering for 15 years, is this MS?

I really need some advice, as I can't continue suffering the way I have been (sorry if I double post, but something seemed to go wrong with my first post). My symptoms started back in high school with muscle stiffness, headaches and blurry vision. The neurologist I was seeing said that I had TMJ pushing on nerves and my stiffness was unrelated and probably arthritis. The stiffness was dx'd as Ankylosing Spondylitis, but after several ...
Read more : Been suffering for 15 years, is this MS? | Views : 288 | Replies : 9 | Forum : Undiagnosed


Could this be MS?

I am really trying to figure out what is going on with me. About a week ago I had what er docs called a migraine. I was driving and had a headache with nausau. Then my hands got tingly and I felt like I was gonna pass out. I pulled over and my hands started clinch up. I had all I could do to barely call 911. They did ct it was clear. I have ...
Read more : Could this be MS? | Views : 232 | Replies : 4 | Forum : Undiagnosed


Sexual function in Multiple Sclerosis

Correlates of Sexual Function in Male and Female Patients with Multiple Sclerosis.

Lew-Starowicz M, Rola R.

Abstract

INTRODUCTION: Many factors have been suggested to contribute to sexual dysfunction (SD) in multiple sclerosis (MS) patients, but the research on their impact on sexual functioning (SF) and sexual quality of life (SQoL) remains scant..... Read more - http://www.ms-uk.org/sex
Read more : Sexual function in Multiple Sclerosis | Views : 229 | Replies : 0 | Forum : General Discussion




Walking and Spasticity

Hey guys. I am undiagnosed but my doctor is almost positive I have MS. I have been unable to walk since Monday. It's getting better and I've been able to walk a few steps with some supervision, but if I do my legs get extremely tight and I have BAD spasms. I was prescribed Baclofen for the spasticity. 10 mg isn't enough and 20 mgs knocks me out (fatigue is awful this week). Even my ...
Read more : Walking and Spasticity | Views : 593 | Replies : 13 | Forum : General Discussion


 

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