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Remyelination can be extensive in multiple sclerosis despite a long disease course 21 April 2007

Patani R, Balaratnam M, Vora A, Reynolds R. Department of Cellular and Molecular Neuroscience, UK MS Tissue Bank, Division of Neuroscience, Imperial College London, Charing Cross Hospital Campus, London, UK.
Experimental studies using models of multiple sclerosis (MS) indicate that rapid and extensive remyelination of inflammatory demyelinated lesions is not only possible, but is the normal situation. The presence of ...
Read more : Remyelination | Views : 1288 | Replies : 3 | Forum : General Discussion

Gene needed for nerve cell insulation found

The end of the article has a sentence about MS. ... wsid=68071

Gene Crucial For Nerve Cell Insulation Discovered By Researchers
21 Apr 2007

Researchers funded by the National Institutes of Health have discovered how a defect in a single master gene
disrupts the process by which several genes interact to create myelin, a fatty coating that covers nerve cells
and increases the speed and reliability of their ...
Read more : Gene needed for nerve cell insulation found | Views : 896 | Replies : 0 | Forum : General Discussion

Does Tysabri infusion hurt?

Hello everybody
i should be soon on Tysabri, i am aware of the risk and seconday effects(headache,...) of it.

MS Society of Canada also says that the infusion is painful in itself:
"A person getting an intravenous infusion will probably feel a sharp pain or some discomfort when the needle penetrates the skin and vein, but then the discomfort should subside as the infusion proceeds. There may also be discomfort when the infusion needle is ...
Read more : Does Tysabri infusion hurt? | Views : 2803 | Replies : 3 | Forum : Tysabri (Antegren or Natalizumab)

CDP323 Oral treatment in trials

Hi Everybody,

My neuro said I could have Tysabri, OR, he offered me the chance to be in one of two trials. The one he thinks I'd be good for is CDP323. I can't find any info on this, does anybody else know anything about it? Here is one link. ... wsid=17278

He said its mechanism is similar to Tysabri, but he thinks a daily pill will have ...
Read more : CDP323 Oral treatment in trials | Views : 5020 | Replies : 15 | Forum : Drug Pipeline

WM and GM lesions occur simultaneously

Abstract from PubMed:

Inflammatory demyelination and neurodegeneration in early multiple sclerosis.

Charil A, Filippi M.

Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.

A number of recent magnetic resonance imaging studies have challenged the classical view of multiple sclerosis (MS) as a "two-stage" disease where an early inflammatory demyelinating phase with focal macroscopic lesions formed in the white matter (WM) of the central nervous system is followed by ...
Read more : WM and GM lesions occur simultaneously | Views : 828 | Replies : 0 | Forum : General Discussion

Must I give up fentanyl?

I have suffered from extraordinary pain from spasticity from MS for three years. I'm allergic to most narcotics (percocet, vicodin, codine, etc.). So when we found that the fentanyl (duragesic) patch gave me no side effects and let me live my life again, I was thrilled.

But then I met a woman who owns one of the premiere compounding pharmacies in the US (Marla - and she recommended LDN and I talked to my ...
Read more : Must I give up fentanyl? | Views : 2137 | Replies : 0 | Forum : Low Dose Naltrexone

RNFL -New Imaging

My neurologist has suggested that I get a Retinal Nerve Fiber Layer (RNFL) imaging of my eyes. The equipment used is an Optical Coherence Tomography machine. The test is non-invasive, and quick. I do not know if insurance will make payment for MS, but my understanding is the cost is minimal. The neuro believes the test will be used in standard treatment of MS within the next couple of years. My non-scientific understanding of the ...
Read more : RNFL -New Imaging | Views : 1453 | Replies : 4 | Forum : General Discussion

Ever had electric shocks in your fingers and/or thumbs ?

If you have ever experienced electric shocks in your fingers and thumbs could you please look at the photographs on my website ..

Read more : Ever had electric shocks in your fingers and/or thumbs ? | Views : 1922 | Replies : 3 | Forum : General Discussion

Exercise and Relapses

Question to anyone: Do you think strenuous exercise can cause a relapse?

I ask this because exercise is so pushed as nothing but a positive for us MS'ers and I have taken that to heart. In the last five years I have barely missed a day of running except this winter during a bad time and horrible weather around here. Since I've started back, I feel like I can barely finish my runs. I start ...
Read more : Exercise and Relapses | Views : 5635 | Replies : 42 | Forum : General Discussion

Fillings and MS

One of those irritating "further study required" conclusions, but the link with amalgam appears weak so far. Size may matter though, (of fillings):

Dental amalgam and multiple sclerosis: a systematic review and meta-analysis.Aminzadeh KK, Etminan M.
Center for Clinical Epidemiology and Evaluation, Vancouver Hospital, Vancouver, Canada.

OBJECTIVES: Amalgam restorations have long been controversial due to their mercury content. Allegations that the mercury may be linked to nervous disorders such as Alzheimer's, chronic fatigue syndrome, and ...
Read more : Fillings and MS | Views : 8429 | Replies : 50 | Forum : General Discussion


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