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ECTRIMS report

A post-hoc analysis from a Phase III clinical trial of AVONEX(R) (interferon beta-1a) and post-randomization eight-year follow up shows that six-month sustained progression of disability at two years, using the Expanded Disability Status Scale (EDSS), is a significant predictor of long-term disability, as measured by EDSS milestones of 4.0, 5.0, 6.0 and 7.0 at eight years, in patients with relapsing-remitting multiple sclerosis (RRMS).

The analysis suggests that patients taking AVONEX for two years were less ...
Read more : ECTRIMS report | Views : 2385 | Replies : 2 | Forum : Avonex

Gene variants linked to MS

Three gene variants have been found to correlate with susceptibility to multiple sclerosis, according to findings of the International Multiple Sclerosis Genetics Consortium (IMSGC) presented here at the 132nd Annual Meeting of the American Neurological Association (ANA).

Variants of interleukin 2RA, interleukin 7RA and CD58 were found to correlate with multiple sclerosis in a whole genome analysis that included about 4,500 participants. "The same finding has been reported in two other papers as well," noted ...
Read more : Gene variants linked to MS | Views : 1944 | Replies : 7 | Forum : General Discussion

Disease-free on Tysabri?

12 October 2007, 14:57:35
Study Shows Increased Proportion of Patients Achieve Disease-Free Status with TYSABRI - Separate Study Demonstrates Plasma Exchange May Be an Effective Tool to Accelerate TYSABRI Removal.

Biogen Idec and Elan Corporation, plc announced that TYSABRI® (natalizumab) treatment significantly increases the proportion of disease-free patients with multiple sclerosis (MS) according to a post hoc analysis of the Phase III AFFIRM study to be presented on Saturday, October 13, 2007 at the 23rd ...
Read more : Disease-free on Tysabri? | Views : 12259 | Replies : 42 | Forum : Tysabri (Antegren or Natalizumab)

Endocannabinnoids and neuroprotection

There's quite a lot of general background information here, but the upshot of it all seems to be that the neuroprotective effects are useful in diseases like MS:

Public release date: 14-Oct-2007

Contact: Professor Raphael Mechoulam
European College of Neuropsychopharmacology

The endocannabinoids: Functional roles and therapeutic opportunities
Cannabis (marijuana) is the most widely produced plant-based illicit drug worldwide and ...
Read more : Endocannabinnoids and neuroprotection | Views : 1347 | Replies : 0 | Forum : General Discussion

Short term cyclophosphamide reduces brain atrophy

I found this one specially interesting because previous studies on autologous stem cell transplants showd a significant increase in brain atrophy. Possible due to the toxic effect of chemo-therapy which would also be relevant for HDC treatment.


Short-term exposure to cyclophosphamide is effective in reducing long-term brain atrophy in refractory relapsing-remitting multiple sclerosis
J. Perumal, F. Bao, Z. Latif, I. Zak, C. Caon, A. Tselis, O. Khan (Detroit, USA)

To investigate the ...

Hi everyone

Hello everyone i'm Michlle.. I just found this forum the other nite. im so glad i did.. i was disgnosed with m.s 3 yr's ago and my medication is avonex.. im just glad ive foung a place where i can talk to other people with the same thing i have. I always seam to talk to people that knows someone with ms but i think it nicer to talk with people that have ms. I ...
Read more : Hi everyone | Views : 1503 | Replies : 3 | Forum : Introductions

High Dose Cyclophosphamide (Revimmune)

American Autoimmune Related Disease Association article from 1995

"Rebooting" - A Promise For Autoimmune Diseases?
Johns Hopkins University researchers have developed a new technique in treating autoimmune disease patients which reboots the immune system with results that have cured some patients while dramatically improving the health of others. This is a new approach to the use of stem cells in treating autoimmune disease.

Autoimmunity occurs when the blood ...
Read more : High Dose Cyclophosphamide (Revimmune) | Views : 2939 | Replies : 4 | Forum : Revimmune (cyclophosphamide or cytoxan)


you ok
Read more : robbie | Views : 2152 | Replies : 3 | Forum : Antibiotics


thank you so much for sending me the info for my doctor. it actually served to purposes. i sent it to my husband at work to copy and he read it. so now he is like 'that lady from england went thru that' 'you're gonna be ok,just wait it out' now my doctor,he is so VERY protective. he put me up to 200mg doxy for 6 weeks then he will add the roxy. IF i ...
Read more : sarah | Views : 2501 | Replies : 6 | Forum : Antibiotics


October 14, 2007
Herbal supplements used to treat multiple sclerosis

Although not recognized in standard allopathic medicine, the use of herbal supplements can be very useful in treating MS.

Fish oil is a natural anti-inflammatory. In addition to treating inflammation caused by multiple sclerosis, fish oil also may have the ability to assist in myelin repair. It is often recommended by alternative medicine practitioners that people with multiple sclerosis take between 3 and 9 grams ...
Read more : Supplements | Views : 1720 | Replies : 2 | Forum : Natural Approach


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