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Cladribine - Phase III results

Oral Multiple Sclerosis drug, Cladribine, appears effective, but cancer cases raise concerns

Merck KGaA reported late-stage data showing that its cladribine tablets significantly cut the rate of clinical relapses, disability progression and brain lesions in patients suffering from relapsing remitting multiple sclerosis, echoing preliminary data reported earlier this year.

But a handful of cancer cases in the study may raise some safety concerns for physicians that must choose cladribine over alternative therapies that have ...
Read more : Cladribine - Phase III results | Views : 2428 | Replies : 3 | Forum : Drug Pipeline

What causes the fatigue?

I think I have a moderate understanding of the way MS works, T cells attack the myalin sheath of specific nerves which affect certain body parts. What I don't understand is how it causes general fatigue.
When asked about fatigue as a symptom of MS, I never really know how to answer. I mean, am I more or less tired than the average person? Am I just lazy, unmotivated, depressed? I don't have a definitive ...
Read more : What causes the fatigue? | Views : 3599 | Replies : 23 | Forum : General Discussion

good cholesterol is good

"Good" cholesterol may guard against MS disability

Reuters -- High levels of HDL ("good") cholesterol may help protect against disabilities related to multiple sclerosis or MS.

HDL has anti-inflammatory properties and thus it might benefit MS, a disease of chronic inflammation. Preliminary data to support this theory were reported today at the American Academy of Neurology's annual meeting in Seattle.

The findings, study investigator Dr. Bianca Weinstock-Guttman told Reuters Health, suggest that people with MS ...
Read more : good cholesterol is good | Views : 1339 | Replies : 2 | Forum : General Discussion

CCSVI - Test and doctor instructions question

Hi all.

I have scheduled an appointment with a vascular surgeon who studied in Italy. The appointment is on May 18th. I will present him with the Zamboni studies and I was thinking about not mentioning that I want to monitor myself because I have MS, but because I feel that I may have an additional venous insufficiency.

I have found out that MRV is non-invasive, apart from the "dye". Can this be enough? Can ...

My review of Provigil

I asked the doctor for adderall. He was against it, he stated that people build up a tolerance to it very easily. Therefore he gave me provigil. I dont know whether it comes in different doses or not but I got the 200mg doses. They are not doing me any good. I can take one then go to bed! I am looking for that evening "get me motivated" energy because I work 3pm-3am. Generally I ...
Read more : My review of Provigil | Views : 3857 | Replies : 15 | Forum : General Discussion


it is bad in my legs, will it stop getting worse or continue till it is constant?
Read more : Clonus | Views : 1602 | Replies : 5 | Forum : General Discussion

Association between multiple sclerosis and cystic structures

Has this study been discussed here before? I found it most interesting...

Association between multiple sclerosis and cystic structures in cerebrospinal fluid.
Brorson O, Brorson SH, Henriksen TH, Skogen PR, Schøyen R.

Dept. of Microbiology, Vestfold Sentralsykehus, Tønsberg, Norway.

BACKGROUND: The aim of the study was to search for infectious agents in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS). PATIENTS AND METHODS: CSF from ten patients with the diagnosis relapsing remitting MS ...
Read more : Association between multiple sclerosis and cystic structures | Views : 1506 | Replies : 1 | Forum : General Discussion

Do you really think there will be a cure?

I love this site...but have to ask. Do you think they will find the cure for this illness. I have to believe they will but everyone on here knows so much about studies and current ideas I just had to ask.

It seems to have eluded the medical world so far and I will be going on Thursday to see my Consultant. To be honest I find it a waste of time as never get ...
Read more : Do you really think there will be a cure? | Views : 8318 | Replies : 53 | Forum : General Discussion

How long after.....

How long after you are first diagnosed, did you have another attack?

I have had just the one attack, over a year ago, and been off medicine, both main stream, or other for about 5-6 months.
Most of my symtpoms have gone, the few I had. The numbness and tingling in the legs as almost all but left, only hot and cold issues with the one leg.

Im starting to wonder if the spinal lesion ...
Read more : How long after..... | Views : 1801 | Replies : 1 | Forum : General Discussion

OK im mad!!!!!!

:x So i went to the doctor today to talk about my worsening symptoms he pretty much did not {sugar coat} anything he said you more than likly have MS for my arm and my foot going to sleep i would have to have 2 pinched nerves one at the top of my spine and one at the bottom,he said im just going to have to battle ...
Read more : OK im mad!!!!!! | Views : 1329 | Replies : 5 | Forum : General Discussion


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