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Immune system destroys Unwanted synapses

An interesting new twist: as the brain grows and develops, connections either grow and are reinforced or fade away and die if they are no use. Except that this piece of research shows they don't just wither away or die through Apoptosis, they are actively killed by the immune system . If this process restarts, or never stops, neurodegeneration can result:

Public release date: 13-Dec-2007
[ Print Article | ...
Read more : Immune system destroys Unwanted synapses | Views : 2533 | Replies : 13 | Forum : General Discussion

pondering diagnostic trends...

Groups such as the Pima Indians, which didn’t have much diabetes 75–80 years ago, now get it in large numbers. Not only are they being sold genetically engineered insulin as a palliative, but they’re also being told that their problem is in their genes (such as having an entirely hypothetical “thrifty gene”).
Whatever inherent susceptibilities the Pima may have to the bad diet that has been forced on them, their genes certainly have not changed ...
Read more : pondering diagnostic trends... | Views : 1597 | Replies : 4 | Forum : General Discussion

search function

howdy, just an FYI, i can't get any searches to work. not even extremely basic ones. will try again later.
Read more : search function | Views : 2031 | Replies : 0 | Forum : Site Support

Biogen News: Back to Reality

UPDATE: Biogen Shares Fall 28% After It Admits It Has No Buyers
December 13, 2007: 12:03 AM EST

Shares of Biogen Idec Inc. plunged as much as 28% in late trading Wednesday after the biotechnology giant said a search for potential buyers failed to turn up suitors.

Biogen's (BIIB) board of directors said Wednesday that it will continue to be an independent company after it did not receive "any definitive offers to purchase the company." ...
Read more : Biogen News: Back to Reality | Views : 1753 | Replies : 4 | Forum : General Discussion

GlaxoSmithKline MS therapies

GSK has provided the following updates for its 2 MS treatments:

Ofatamumab & firategrast — Promising compounds for the treatment of MS:

Few treatments exist for MS, a chronic and debilitating neurological disease, which means there is a significant medical need for more effective and more convenient treatments.

Ofatumumab (HuMax-CD20), a promising monoclonal antibody, will move into phase II development early in 2008, exploring its potential in patients with relapsing-remitting MS. The programme, to ...
Read more : GlaxoSmithKline MS therapies | Views : 1525 | Replies : 0 | Forum : Drug Pipeline

Computers to predict drug side effects

This is one way the drug discovery process should speed up in the coming years.

New Computational Technique Can Predict Drug Side Effects

ScienceDaily - December 13, 2007 - Early identification of adverse effects of drugs before they are tested in humans is crucial in developing new therapeutics, as unexpected effects account for a third of all drug failures during the development process. Now researchers at the University of California, San Diego (UCSD) have developed ...
Read more : Computers to predict drug side effects | Views : 1463 | Replies : 0 | Forum : Drug Pipeline


Here is some further info on the recent ECTRIMS conference. The first is an interesting interview with Dr Mark Freedman.

These links were posted on the ACP website today.

Read more : ECTRIMS 2007 | Views : 1181 | Replies : 0 | Forum : General Discussion

ACP video

Accelerated Cure Project has a new video detailing exactly what the organization does. I encourage you to watch the video. Let me know what you think.
Read more : ACP video | Views : 1238 | Replies : 0 | Forum : General Discussion

Azathioprine trial results from Iran

A drug that's been discussed a bit lately here. Azathioprine has been used off-label for MS since the 60s or 70s. Maybe it's not a bad option as it is a pill. Balance that off with more serious side-effects because it's an immunosuppressant.

Comparison of interferon beta products and azathioprine in the treatment of relapsing-remitting multiple sclerosis.

J Neurol. 2007 Dec 14
Etemadifar M, Janghorbani M, Shaygannejad V.
Dept. of Neurology ...
Read more : Azathioprine trial results from Iran | Views : 1653 | Replies : 1 | Forum : Drug Pipeline


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