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Avigen Receives Approval to Initiate AV650 Phase II Clinical Development

Avigen, Inc. a biopharmaceutical company developing innovative therapies for the treatment of neurological conditions, today announced it was given approval from the U.S. Food and Drug Administration to commence Phase II clinical development of AV650 (tolperisone).

AV650 is a New Chemical Entity (NCE) in the United States. Tolperisone is approved in several EU member countries for the treatment of spasticity and muscle spasms. Avigen's initial ...
Read more : AV650 | Views : 1639 | Replies : 1 | Forum : Drug Pipeline


Artielle ImmunoTherapeutics Initiates Clinical Trials For Multiple Sclerosis

Artielle ImmunoTherapeutics, Inc. today announced that the company has initiated a Phase I clinical trial to evaluate its novel drug candidate, RTL1000, for the treatment of multiple sclerosis (MS). RTL1000 is a novel protein drug with a highly-selective mechanism of action that targets pathogenic T-cells responsible for triggering and sustaining MS.
The trial is currently open for enrollment and is a multi-center, double-blind, placebo controlled, single dose ...
Read more : RTL1000 | Views : 3398 | Replies : 0 | Forum : Drug Pipeline

Chemical cues to turn stem cells into neurons

Making stem cells develop along the right lines is essential, and they need certain chemical signals to do this. Discovering these sounds like a significant advance...

Public release date: 14-Mar-2007

Contact: Joseph Bonner
Rockefeller University

In order to differentiate and specialize, stem cells require very specific environmental cues in a very specific ...
Read more : Chemical cues to turn stem cells into neurons | Views : 1534 | Replies : 1 | Forum : Stem Cells

Neurology Conferences

Hi all,

In the couple of years that I've had MS, it seems that although there is a steady stream of information generated about MS, some of the more notable results from research are presented at the major neurology conferences. I was wondering if there is a comprehensive list of the major conferences, so one might have an idea of when to expect these sorts of things. For example, I googled AAN and their yearly ...
Read more : Neurology Conferences | Views : 1748 | Replies : 3 | Forum : General Discussion

C3 necessary for 'maximal' EAE

Complement is part of the immune system. C3b is an Opsonin, (helps white blood cells to bind to foreign tissue), and it sounds to me as if C3b mistakenly binds to self-tissue, thus bonding it to white blood cells, which then destroy it.
C3a also can trigger the release of histamine, which may play a part in some forms of MS:

Read more : C3 necessary for 'maximal' EAE | Views : 838 | Replies : 0 | Forum : General Discussion

Psychosocial impact of MS

Just a little reminder to neuros that we're not just a bundle of faulty wiring. I wish I could get hold of the full texts to these abstracts--anyone got friends in high places?


Read more : Psychosocial impact of MS | Views : 1324 | Replies : 2 | Forum : General Discussion

MS and heart rate

Looks as if MS can impair your body's ability to regulate the heart....dammit! Does that mean I'll have to give up mountaineering? :wink:


Read more : MS and heart rate | Views : 1483 | Replies : 4 | Forum : General Discussion

Inflammation and degeneration together

We know that both processes occur in MS, and it's not an either/or question. They acknowledge here that treating just one may be detrimental, (presumably inflammation, because it can be helpful):


Read more : Inflammation and degeneration together | Views : 1278 | Replies : 0 | Forum : General Discussion


Hello, 14 days ago I had terrible reaction on copaxone. Vomiting, problems with breath and so on...

From the time I have during a day problems with terrible burning (in my head especially, than my shoulder and chest) and with feeling of lack of air in my lungs, I am afrai of swooning but it never happens). Does anybody know this? Is it from MS, or from Copaxone? My doctor doesn´t know and I´am very ...
Read more : Burning | Views : 1634 | Replies : 3 | Forum : General Discussion

Why do relapses go?


I recently wondered how it could be possible, following the traditional autoimmune theory, that the immune system comes to the point where it attacks the mylin sheath and after some time/event it calms down and stays quiet until the next relapse.

As far as I know, if the immunesystem comes across an "enemy" structure the immune-cascade is going on as strong as necessary, until the enemy structure is completly removed (or at least no ...
Read more : Why do relapses go? | Views : 1654 | Replies : 5 | Forum : General Discussion


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