http://www.ncbi.nlm.nih.gov/sites/entre ... d=17445357
Department of Neurology, Neuroimmunology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Growing evidence indicates immunoregulatory effects of various antidepressants. Through the interaction of the nervous and immune systems, the norepinephrine-serotonin system was shown to modulate inflammatory CNS diseases. Thus, we examined the norepinephrine-serotonin reuptake inhibitor venlafaxine in an astroglia-microglia co-culture model which allows mimicking of an inflammatory milieu by increasing the cultured microglial fraction. Astrocytic membrane resting ...