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Campath interim results

This is interesting.

"Analysis of the first co-primary endpoint showed that patients taking alemtuzumab at high and low doses experienced at least a 75 percent reduction in the risk for relapse after at least two years of follow up when compared to patients treated with interferon beta-1a."

That's pretty amazing because they're not saying a 75% overall reduction, they're seeing a 75% reduction compared to Rebif! And the Campath patients have only had 2 infusions ...
Read more : Campath interim results | Views : 2932 | Replies : 6 | Forum : Campath (Lemtrada, Alemtuzumab)


Horrid story

Not a nice story, but you do see these stories every now and then. If some of the drugs in the pipeline come good, hopefully none of us should be in this position. But it emphasises what a cruel disease this is if some would opt for death rather than go on with it.

Ian


Gardener admits helping wife die

A landscape gardener has admitted aiding and abetting the suicide of his wife, who ...
Read more : Horrid story | Views : 4935 | Replies : 28 | Forum : General Discussion


New to me. Stem cells from Fat and an old story.

I found the following, which, although not MS specific, seems something positive.

Proceedings of the National Academy of Sciences reports that researchers have extracted adult stem cells from fatty tissue (adipose) and turned them into smooth muscle cells


In addition, there would be no need to use anti-rejection drugs. Rodriguez is currently trying to identify and develop growth factors that will speed up the transformation of adipose stem cells.


http://www.scienceagogo.com/news/20060624230632data_trunc_sys.shtml

And although this story is ...
Read more : New to me. Stem cells from Fat and an old story. | Views : 1477 | Replies : 0 | Forum : Stem Cells


FTY720

Some news on FTY720 - further data to be presented at the end of the month.

Ian

Phase II Data Showing Clinical Benefits of Novel Once-Daily Oral Multiple Sclerosis Therapy FTY720 (Fingolimod) Published in New England Journal of Medicine

* One-year data show significant reductions in inflammatory disease activity and clinical relapse activity with daily oral FTY720 were maintained for up to one year
* Phase III program investigating FTY720 now being implemented in ...
Read more : FTY720 | Views : 15201 | Replies : 72 | Forum : Drug Pipeline


Vitamin D once again in the spot light

Bottled sunshine: The value of vitamin D
Why does flu break out as the nights draw in? Scientists have seen the light - we don't get enough of it.
By Jeremy Laurance
Published: 13 September 2006
Every winter, as the nights draw in and the weather grows cold, people start to cough, sniffle and run a fever. Patients crowd doctors' surgeries and sales of painkillers, hot lemon drinks and cough syrup soar. Flu is back. ...
Read more : Vitamin D once again in the spot light | Views : 944 | Replies : 0 | Forum : General Discussion


HHV-6 and anti-viral compounds

HHV-6 hasn't come up for a while, but it's interesting that they are testing anti-viral compounds against HHV-6. It isn't MS-specific right now, but they mention MS.



Efficacy of antiviral compounds in human herpesvirus-6-infected glial cells.

J Neurovirol. 2006 Aug;12(4):284-93.
Akhyani N, Fotheringham J, Yao K, Rashti F, Jacobson S.
Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

The beta-herpesvirus human herpesvirus-6 (HHV-6) is becoming increasingly ...
Read more : HHV-6 and anti-viral compounds | Views : 967 | Replies : 0 | Forum : General Discussion


Stem Cell Therapeutics

I think EPO is on the list.

Ian


Stem Cell Therapeutics Options Schizophrenia and Multiple Sclerosis Clinical Programs

Stem Cell Therapeutics Corp. (SCT), a Canadian biotechnology company engaged in treating central nervous system (CNS) disorders by stimulating endogenous neural stem cells, is pleased to announce that it has entered into an Option to Acquire agreement for up to two additional clinical stage programs, one in schizophrenia and the other in multiple sclerosis. The agreement ...
Read more : Stem Cell Therapeutics | Views : 1024 | Replies : 0 | Forum : Drug Pipeline


Transition Therapeutics

Dignan,

Came across this company who have an MS drug in trial (seems to improve effectiveness of interferons). You may want to add it to your list.

Ian




http://www.transitiontherapeutics.com/technology/ms.php
Read more : Transition Therapeutics | Views : 1096 | Replies : 1 | Forum : Drug Pipeline


Tovaxin and method?

I have seen the video of the theory of how this works. The one thing that is not clear, is how they identify the cells that attack myelin? Do they use myelin from the patient? any old myelin laying round the lab? or what? or is this their little secret.
Read more : Tovaxin and method? | Views : 1358 | Replies : 0 | Forum : General Discussion


Autoreactive T-Cell Generation (hypothesis)

Although, not MS specific, and I am reading into it things the hypothesis isnt aiming for...

... results in too few T cells, and the body tries to correct this by inducing a vigorous expansion of the remaining T cells, creating a more autoreactive population.

http://www.scienceagogo.com/news/20040315203720data_trunc_sys.shtml

I read this as another theory of how our immune cells become auto-reactive.
Read more : Autoreactive T-Cell Generation (hypothesis) | Views : 2089 | Replies : 9 | Forum : General Discussion


 

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