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Cigarette Smoking May Accelerate Disability In Those With MS

Cigarette Smoking May Accelerate Disability In Those With MS

Science Daily — Persons with multiple sclerosis who smoke risk increasing the amount of brain tissue shrinkage, a consequence of MS, and the subsequent severity of their disease, new research conducted at the Buffalo Neuroimaging Analysis Center (BNAC) at the University at Buffalo has shown.

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Read more : Cigarette Smoking May Accelerate Disability In Those With MS | Views : 1328 | Replies : 0 | Forum : General Discussion


Early Research Into A Treatment For Progressive MS

Thought I'd posted this before, but can't see it now...

Main Category: Multiple Sclerosis News
Article Date: 01 Oct 2007 - 4:00 PDT

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Scientists in Scotland may be on the way to discovering the cause of long term disability in people with multiple sclerosis (MS).

New research carried out at the University ...
Read more : Early Research Into A Treatment For Progressive MS | Views : 2171 | Replies : 9 | Forum : General Discussion


LDN study abstract from ECTRIMS

No mention of efficacy yet, but at least they're talking about an LDN trial at a major MS conference!



Pilot multicentric study of low dose naltrexone in primary progressive multiple sclerosis

M. Gironi, F. Martinelli Boneschi, C. Solaro, R. Cavarretta, M. Zaffaroni, L. Moiola, S. Bucello, M. Radaelli, V. Pilato, M. Rodegher, M. Cursi, V. Martinelli, R. Nemni, G. Comi, P. Sacerdote, G. Martino (Milan, Genoa, Gallarate, I)

Preliminary evidence have documented an interesting symptomatic ...
Read more : LDN study abstract from ECTRIMS | Views : 2628 | Replies : 0 | Forum : Low Dose Naltrexone


Plasma exchange and disability ECTRIMS abstract

These results blow me away. This is the part I'm referring to:

Improvement in disability with PE occurred in 217 of the 271 pts (p < 0.0001). Ten percent of the pts improved by 2.5 steps on EDSS, 25% by 1.5, 50% by one and the rest less than one. This improvement was well sustained at 6-year follow up (p < 0.001) and stabilized during the years 7 to 9. From years 10-25, the pts ...
Read more : Plasma exchange and disability ECTRIMS abstract | Views : 5509 | Replies : 16 | Forum : Drug Pipeline


Potassium channel modulator at ECTRIMS

I include this preclinical abstract because the substance being tested is a voltage-gated potassium channel modulator. I think this strategy could be promising to provide neuroprotection, and this is the first oral drug I've seen in the preclinical stage that goes after Kv1.3 (1.3 is the channel of interest for MS).



BNC-245 – a novel compound for multiple sclerosis treatment

E. Andriambeloson, S. Wagner, L. Gorj, J. Bindler, J. Mould, B. Flynn (Illkirch, F; Adelaide, ...
Read more : Potassium channel modulator at ECTRIMS | Views : 2104 | Replies : 2 | Forum : Drug Pipeline


Rituxan results from ECTRIMS

Looks like rituxan is pretty good at reducing lesions, but then so is high-dose interferon, but it's effect on relapses isn't quite as impressive. I guess I'm more hopeful about rituxan as a treatment for PPMS anyway, so relapses won't matter in that trial.



Safety and efficacy of rituximab in adults with relapsing-remitting multiple sclerosis: results of a phase II placebo-controlled, multicentre trial through 48 weeks

E. Waubant, S. Hauser, D.L. Arnold, T. Vollmer, J.P. ...
Read more : Rituxan results from ECTRIMS | Views : 9351 | Replies : 32 | Forum : Drug Pipeline


AHSCT status report from ECTRIMS

The notable part of this for me is that the author describes the ASTIMS trial as a phase 2, not a phase 3 as the clinicaltrials.gov site lists it. There have been other reviews in Pubmed that describe it as a phase 3 I think so I won't change the list.



Present status of HSCT in MS

G.L. Mancardi (Genoa, I)

In the last years, intensive immunosuppression followed by autologous transplantation of hematopoietic stem cells ...
Read more : AHSCT status report from ECTRIMS | Views : 1297 | Replies : 0 | Forum : Drug Pipeline


Treosufan study results from ECTRIMS

Sorry for stealing your thunder Bromley. I wish they could have run the study long enough to use progression as an endpoint instead of relapses, considering this is a study for secondary progressive. Still it's good to see studies targeting progressive MS.



Treatment of active secondary progressive Multiple sclerosis with treosulfan

H. Wiendl, B.C. Kieseier, R. Weissert, H.-P. Hartung, A. Melms, W. Kueker, M. Weller (Wurzburg, Dusseldorf, Tubingen, D; Oxford, UK)

Objective: Safety and efficacy ...
Read more : Treosufan study results from ECTRIMS | Views : 1610 | Replies : 0 | Forum : Drug Pipeline


I have never felt this bad in my life. Is this the Rebif?

I now have such a problem with this drug. I never knew it until I had a lapse in my insurance coverage and had to be off the meds for six weeks. I felt great (still had MS i know... but life was better)!!! I am now back into the dull everyday life of M.S. and the limitations that that brings to the table. I hope that these flu like symptoms will go away! I ...
Read more : I have never felt this bad in my life. Is this the Rebif? | Views : 12987 | Replies : 24 | Forum : Rebif




 

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