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Methylthioadenosine

Another promising compound to add to the pre-clinical list.



Methylthioadenosine reverses brain autoimmune disease.

Ann Neurol. 2006 Jun 19;
Moreno B, Hevia H, Santamaria M, Sepulcre J, Munoz J, Garcia-Trevijano ER, Berasain C, Corrales FJ, Avila MA, Villoslada P.
Neuroscience and Gene Therapy Division, Center for Applied Medical Research, University of Navarra, Navarra, Spain.

OBJECTIVE: To assess the immunomodulatory activity of methylthioadenosine (MTA) in rodent experimental autoimmune encephalomyelitis (EAE) and in patients with multiple sclerosis. ...
Read more : Methylthioadenosine | Views : 1149 | Replies : 0 | Forum : Drug Pipeline


IL-17 role in MS further clarified

Looks as though we all owe interferon-gamma a bit of an apology...and IL-17 is coming right off my Christmas card list...



IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis.

J Immunol. 2006 Jul 1;177(1):566-73.
Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, Sudo K, Iwakura Y.
Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

IL-17 is a proinflammatory cytokine that activates T ...
Read more : IL-17 role in MS further clarified | Views : 924 | Replies : 0 | Forum : General Discussion


Phase I for cathepsin S inhibitor CRA-028129

Good news that they are announcing a drug I've never heard of that's already in phase I trials for MS.



Celera Genomics Announces the Sale of Its Cathepsin S Inhibitor Program to Schering AG; Transaction Completes Celera's Planned Exit from Small Molecule Development

Business Wire - June 21, 2006 - Celera Genomics, an Applera Corporation business, today announced that Schering AG has acquired its cathepsin S inhibitor small molecule drug program for the treatment of ...
Read more : Phase I for cathepsin S inhibitor CRA-028129 | Views : 1783 | Replies : 2 | Forum : Drug Pipeline


ACT Diet

Hi does anyone have a list of the diet given out by ACT clinic? My mother has MS and although we still have while to go until we have saved up the funds, she wants to try the diet from now to get prepared. Also if there is any other information they give to you on what you need to do in preparation (ie. Physio, etc). Any info. will be greatly appreciated!
Read more : ACT Diet | Views : 1415 | Replies : 0 | Forum : Stem Cells


Do you take your own supply of stem cells?

Hi at this clinic, do you take your own stem cells or do they provide you with them there? I am currently pregnant and am going to store the umbilical cord blood as my mother has MS and I was wondering if she can use them?
Read more : Do you take your own supply of stem cells? | Views : 1435 | Replies : 0 | Forum : Stem Cells


Paralysed rat

Normally I would put this under stem cells but an interesting read. Interesting that they may trial on pigs before humans. You'd think they could come up with a pig model of MS. As usual the good times are five years away - but a little bit of progress is better than none.

http://c.moreover.com/click/here.pl?j562399231&w=464753
Read more : Paralysed rat | Views : 889 | Replies : 0 | Forum : General Discussion


Jimmylegs--from Netherlands Daughter

Hey Jimmylegs--just wanted to first thank you for providing some insight into what my daughter has embarked on! Your info was very informative. Now, she does not have to take the parasite treatment (if that is what it is). She wanted to take all the phases. She was only recommended the one for a severe strep bacteria infection. Second, I want to explain to you where I am coming from.

First, I have read about ...
Read more : Jimmylegs--from Netherlands Daughter | Views : 2137 | Replies : 7 | Forum : Natural Approach


Chat rooms????

Hi
I really love this site. It gives me hope and a lot of information that I need. There are a lot of people on this site that I would love to get to know. I think the more we know each other, the more we may be able to help each other. With all that said, I was wondering how everyone feels about having chat rooms????
Arron, would that be possible? That way, if ...
Read more : Chat rooms???? | Views : 3617 | Replies : 4 | Forum : Suggestions


20% Smaller Needle

AVONEX(R), The Most Prescribed Multiple Sclerosis Therapy Worldwide, May Now Be Given with Smaller Needle

Tuesday June 20, 9:32 am ET
Additional Supplemental Application for Convenient Needle Locking System and Change In Room Temperature Storage Filed with FDA

CAMBRIDGE, Mass.--(BUSINESS WIRE)--June 20, 2006--AVONEX® (Interferon beta 1a), the most prescribed multiple sclerosis (MS) therapy worldwide may now be administered with a needle that is 20 percent shorter and thinner than the currently approved needle. People living ...
Read more : 20% Smaller Needle | Views : 5522 | Replies : 5 | Forum : Avonex


infusion centers?

Has anyone come across where the infusion centers will be located in the US?
Read more : infusion centers? | Views : 4831 | Replies : 16 | Forum : Tysabri (Antegren or Natalizumab)


 

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