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15d-PGJ(2)

Here's another one I just stumbled across that I think qualifies for pre-clinical...



Hormone regulation of microglial cell activation: relevance to multiple sclerosis.

Brain Res Brain Res Rev. 2005 Apr;48(2):322-7. Epub 2005 Jan 19.
Drew PD, Storer PD, Xu J, Chavis JA.
Department of Neurobiology and Developmental Sciences-Slot 510, University of Arkansas for Medical Sciences, Shorey Building, Little Rock, 72205, USA. drewpauld@uams.edu

Peroxisome proliferator-activated receptors (PPARs) are members of the ...
Read more : 15d-PGJ(2) | Views : 1901 | Replies : 4 | Forum : Drug Pipeline


Thymus

Read more : Thymus | Views : 844 | Replies : 0 | Forum : General Discussion


Methylthioadenosine (whatever that means)

Sounds like this research is still in the early stages, but they mention that MTA could be of benefit in MS, so I think it will go in the "pre-clinical" section of the pipeline.



Protective action of a molecule in inflammatory processes discovered

Henar Hevia Pérez, researcher in the area of Genic Therapy and Hepatology at the Applied Medicine Research Centre (CIMA)of the University of Navarra, has discovered the protective role of the methylthioadenosine (MTA) ...
Read more : Methylthioadenosine (whatever that means) | Views : 1149 | Replies : 0 | Forum : Drug Pipeline


Lipoic acid research

Here's another bit of evidence for lipoic acid...



Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck).

Biochem Biophys Res Commun. 2006 Apr 5
Marracci GH, Marquardt WE, Strehlow A, McKeon GP, Gross J, Buck DC, Kozell LB, Bourdette DN.
Portland Veterans Affairs Medical Center, R&D-65, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA; Department of Neurology, Oregon Health and Science University, Portland, OR, USA.

Lipoic acid is an antioxidant ...
Read more : Lipoic acid research | Views : 2349 | Replies : 5 | Forum : Natural Approach


More on insulin

I can't remember, is anyone here interested in the possible role of insulin in MS? This is for you lyndacarol...



Insulin resistance, inflammation, and cognition in Alzheimer's Disease: Lessons for multiple sclerosis.

J Neurol Sci. 2006 Apr 20
Watson GS, Craft S.
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA.

Insulin resistance (reduced ability ...
Read more : More on insulin | Views : 1095 | Replies : 3 | Forum : General Discussion


Muscle Twitching (fasciculations)

Something I noticed is that probably once every two days I'll get a twitching muscle in my calf muscle, thigh, forearm, or upper arm. Is this normal? Or is this indicative of active MS? The only symptom I've had of MS (which led to my diagnosis) was nystagmus in June '05, which has since gone away. I am a 26 y/o male. Does anyone else experience this? It has never really concerned me, but it ...
Read more : Muscle Twitching (fasciculations) | Views : 15296 | Replies : 5 | Forum : General Discussion




More lesions

The researchers have found that we've got more lesions than we thought.

http://www.msif.org/en/research/researc ... f_les.html
Read more : More lesions | Views : 1069 | Replies : 0 | Forum : General Discussion


Brain atrophy

The only good thing about this research is that future treatments may be judged on their ability to stop atrophy.

http://www.msif.org/en/research/researc ... es_of.html
Read more : Brain atrophy | Views : 1049 | Replies : 0 | Forum : General Discussion


Damage to White Matter and Grey Matter

More research showing that damage occurs in both the White Matter and Grey Matter. They need to shift to identifying why!

http://www.msif.org/en/research/researc ... fusio.html
Read more : Damage to White Matter and Grey Matter | Views : 867 | Replies : 0 | Forum : General Discussion


 

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