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Venlafaxine (Effexor) exhibits anti-inflammatory effect

Abstract:

http://www.ncbi.nlm.nih.gov/sites/entre ... d=17445357

Department of Neurology, Neuroimmunology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Growing evidence indicates immunoregulatory effects of various antidepressants. Through the interaction of the nervous and immune systems, the norepinephrine-serotonin system was shown to modulate inflammatory CNS diseases. Thus, we examined the norepinephrine-serotonin reuptake inhibitor venlafaxine in an astroglia-microglia co-culture model which allows mimicking of an inflammatory milieu by increasing the cultured microglial fraction. Astrocytic membrane resting ...
Read more : Venlafaxine (Effexor) exhibits anti-inflammatory effect | Views : 1914 | Replies : 1 | Forum : General Discussion


to watergypsy

Hey, I sent you a messege
Read more : to watergypsy | Views : 1174 | Replies : 0 | Forum : General Discussion


New venture

Interesting combination...



Hadasit, Harvard Medical School in autoimmune venture

The venture looks to research oral delivery of antibodies currently administered intravenously.

Globes - 23 Jan 08 - Hadasit Technology Transfer Company of Hadassah University Hospital Ltd., Harvard Medical School, and its affiliate Brigham and Women’s Hospital have set up a joint scientific venture to develop a new orally administered therapeutic treatment for autoimmune diseases. The parties will own the venture in equal shares. This is ...
Read more : New venture | Views : 1320 | Replies : 0 | Forum : Drug Pipeline


Copaxone long-term study

Now that's some long-term follow up!



Long-term (up to 22 years), open-label,compassionate-use study of glatiramer acetatein relapsingremitting multiple sclerosis.

Mult Scler. 2008 Jan 21
Miller A, Spada V, Beerkircher D, Kreitman RR.
Mount Sinai School of Medicine, New York, NY, USA.

To evaluate the safety and efficacy of long-term glatiramer acetate (GA) therapy, 46 patients with relapsingremitting multiple sclerosis (RRMS) were treated for up to 22 years in an ongoing, open-label ...
Read more : Copaxone long-term study | Views : 4004 | Replies : 5 | Forum : Copaxone


Estriol

I hadn't heard about this...



FDA Launches Misguided Attack on Estriol, Despite Proof it is Safe and Effective for Women, says Dr. Erika

"Why would the FDA try to take estriol off the market when it is not only safe for women in menopause, it may even help women with multiple sclerosis," writes Dr Erika. Maybe it is because the agency is more concerned with protecting Wyeth than it is with protecting women, she says. ...
Read more : Estriol | Views : 4343 | Replies : 7 | Forum : Drug Pipeline


EBV

Everyone loves EBV...



Selective association of multiple sclerosis withinfectious mononucleosis.

Mult Scler. 2008 Jan 21
Zaadstra BM, Chorus AM, Van Buuren S, Kalsbeek H, van Noort JM.
Department of Prevention and Care, TNO Quality of Life, Leiden, The Netherlands and Netherlands Interdisciplinary Demographic Institute, The Hague, The Netherlands.

Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association ...
Read more : EBV | Views : 1510 | Replies : 0 | Forum : General Discussion


Hello from London

Hi everyone,

Stumbled across this site looking up LDN and the pro and cons as my neurologist is unsure of its findings ?

Anyway Iam Simon from London,England. 37 years old, married and 1 stepson. Finally diagnosed with MS last summer 2006 with a MRI scan after spending a week in St.Thomas' Hospital. Been a long journey looking for answers for at least 4 years, eventhough both my parents have MS and my fathers brother ...
Read more : Hello from London | Views : 2009 | Replies : 4 | Forum : Introductions


RTL-1000 phase-I recruiting

OHSU are initiating a 3-4 month placebo (2:1) controled phase-I trial in RRMS and SPMS:
http://www.ohsu.edu/research/rda/so/vie ... RB00002426

--Frank
Read more : RTL-1000 phase-I recruiting | Views : 2962 | Replies : 2 | Forum : Drug Pipeline


New therapeutic target

Went to Cambridge today for a check-up. As I came out of the lift I bumped into Raven (Robin) - what a small world.

I have now met four posters on this site - Raven, Muu, Loriyas and Jaded. Can anyone beat that?

I never want to meet Lyon (because of the shiny shirts mainly) or Chris55 (who is a sandwich short of a picnic) - just thinking out loud.

I'd like to meet Jimmylegs ...
Read more : New therapeutic target | Views : 2236 | Replies : 9 | Forum : General Discussion


More Worms for Bob

I thought you might find this interesting Bob: an antigen from the eggs of parasitic worms seems to restrict the development of EAE in mice, though not if given after the onset of the disease:
J Neuroimmunol. 2008 Jan 18
Related Articles

Soluble egg antigen from Schistosoma japonicum modulates the progression of chronic progressive experimental autoimmune encephalomyelitis via Th2-shift response.

Zheng X, Hu X, Zhou G, Lu Z, Qiu W, Bao ...
Read more : More Worms for Bob | Views : 1518 | Replies : 0 | Forum : General Discussion


 

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