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FTY720

Novartis published first quarter results today. The following info was provided on FTY720:

FTY720 (fingolimod), an oral once-daily treatment for relapsing forms of multiple sclerosis (MS), is currently in Phase III development. Discussions are continuing with the FDA on starting a Phase III study in the US. Data from an extension of a Phase II trial to 18 months presented in April confirmed the substantial efficacy of FTY720 in significantly reducing the relapse rate and ...
Read more : FTY720 | Views : 1585 | Replies : 1 | Forum : Drug Pipeline


IL-4 Expression by Mast Cells

IL-4 Expression By Mast Cells Modifies The Immune Response In Multiple Sclerosis
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Allergy Multiple Sclerosis



Main Category: Immune System / Vaccines News
Article Date: 23 Apr 2006 - 17:00pm (PDT)

IL-4 is expressed by many types of immune cells and it can act on a variety of other immune as well as non-immune cells to modulate the immune response. This broad range of effects necessitates strict control of IL-4 expression ...
Read more : IL-4 Expression by Mast Cells | Views : 788 | Replies : 0 | Forum : General Discussion


MS and Heat, Why?

Hi,

This seems like such a "known", yet I cant find any distinctive medically accepted reason for it. ie MS'ers heat intolerance.

What are the current thoughts on this by the medical profession?

I understand the Prokarin / histamine train of thought, but i am guessing this is not the general practice / accepted reason. or is it?

I am guessing there must be some "accepted" rationale behind it considering Ive herd it was the ...
Read more : MS and Heat, Why? | Views : 4403 | Replies : 21 | Forum : General Discussion


First injection over!!

Well, started the Avonex last night and I have to say the injection wasn't as bad as I had anticipated. It didn't hurt at all and was over in a second.

The side effects kicked in about 4 hours later while in bed (had been trying to get to sleep quick in order to miss them but it never happens when you want it to!). Started feeling a little bit achy, then shivery, then absolutely ...
Read more : First injection over!! | Views : 2689 | Replies : 4 | Forum : Avonex


Neurovax presentation

Here is a link to a presentation on the Immune Response Corp's website about their clinical pipeline, including Neurovax. Not sure if there's anything new here, but it was nice to see their timeline for the upcoming phase IIb Neurovax trial.

http://www.imnr.com/ir/2006APR19.htm

if that doesn't work, this one might (select the link at the end of the first paragraph):

http://www.imnr.com/news/2006/2006APR20.htm
Read more : Neurovax presentation | Views : 1585 | Replies : 0 | Forum : Drug Pipeline


Transition Therapeutics

Dignan,

I stumbled across Transition Therapeutics (Canadian company). They have the following drug/s? in trial. Not sure if it / they are on your list?

Ian

Clinical Development

A Phase II clinical trial is underway in MS patients with data expected in the second half of calendar 2006. A Phase I clinical trial has demonstrated that EMZ701 is well-tolerated and has a good safety profile.

Creating Best-In-Class Multiple Sclerosis Product

Transition is developing MS-I.E.T. (a ...
Read more : Transition Therapeutics | Views : 1331 | Replies : 1 | Forum : Drug Pipeline


My removed my post

I removed my post
Read more : My removed my post | Views : 1211 | Replies : 2 | Forum : General Discussion


FDA Rejects Medical Marijuana

Hi all

Just saw an article in the Washington Post FDA Rejects Medical Marijuana

WASHINGTON -- The Food and Drug Administration said Thursday that it does not support the use of marijuana for medical purposes....

contradicts a 1999 finding from the Institute of Medicine, part of the National Academy of Sciences, which reported that "marijuana's active components are potentially effective in treating pain, nausea, the anorexia of AIDS wasting and other symptoms, and should be ...
Read more : FDA Rejects Medical Marijuana | Views : 1127 | Replies : 3 | Forum : General Discussion


numbness/tingling

I have numbness/tingling in my left hand, leg and foot. I've had this since I was dxd in May 2002. I have been on Neurontin, which worked well to control it but caused weight gain. I was then on Topamax which thankfully caused weight loss but didn't do as well to control the numbness/tingling and made me feel a little "spacey". I am now on Cymbalta which is working well for the numbness/tingling symptom but ...
Read more : numbness/tingling | Views : 1487 | Replies : 3 | Forum : General Discussion


Biogen Sponsored Talks

I'm interested in attending an MS talk sponsored by MS Active Source (Biogen). I was wondering if anyone has been to these Biogen sponsored talks and what their experience has been. For example, are they actually informative, i.e., are they willing to discuss CAM treatments and other experimental therapies, or are they just reiterating the message that can be found in the CRAB literature?

Thanks, NHE
Read more : Biogen Sponsored Talks | Views : 1183 | Replies : 2 | Forum : General Discussion


 

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