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Interesting answer about atrophy and axonal damage. Good to hear that research is very active in this area and work underway looking at neuro-protection. Sometimes when I read these sorts of answers, I'm still not clear if it is the myelin which is damaged first and then the axons, or the axons are damaged first resulting in secondary damage to the myelin!

Read more : Atrophy | Views : 1714 | Replies : 13 | Forum : General Discussion

IL 23

Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia.

Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX.
Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.

IL-12 has long been considered important in the pathogenesis of multiple sclerosis. However, evidence from recent studies strongly supports the critical role of IL-12-related proinflammatory cytokine IL-23, but not IL-12, in the development of experimental autoimmune encephalomyelitis (EAE), an animal model ...
Read more : IL 23 | Views : 1080 | Replies : 1 | Forum : General Discussion

First MRI on Copaxone

How soon after starting Copaxone should one have an MRI done, given the fact that the drug takes 6 months or so to start working?
Read more : First MRI on Copaxone | Views : 5078 | Replies : 5 | Forum : Copaxone

Parkinson's, MS more common than thought

U.S. survey boosts estimates of major neurological diseases
Updated: 11:10 a.m. ET Jan 30, 2007
WASHINGTON - Multiple sclerosis, Parkinson’s disease and other neurological diseases may be far more common than most people had believed, according to the latest estimates.
Nearly one out of 1,000 Americans has multiple sclerosis or MS and one out of 100 elderly Americans has Parkinson’s disease the survey found.
“Our estimate of MS prevalence is about 50 percent higher than ...
Read more : Parkinson's, MS more common than thought | Views : 954 | Replies : 0 | Forum : General Discussion


Tanabe Resumes MS Drug Study

Japanese pharmaceutical company Tanabe Seiyaku has resumed a phase II trial of its multiple sclerosis treatment after the FDA released its clinical hold on the study.

The drug, T-0047, was placed on clinical hold by the FDA in response to the reports that progressive multifocal leukoencephalopathy (PML), a rare nerve disorder, was associated with Tysabri. Tysabri is marketed by Biogen Idec and Elan Pharmaceuticals and is a monoclonal antibody ...
Read more : T-0047 | Views : 1239 | Replies : 1 | Forum : Drug Pipeline

Familial influences and MS.

Here is a link to an article I found on, "MedPage Today", ... is/tb/4953

To be honest, I think they could have saved themselves the trouble and just written, "MS is quite complicated".

Ah well. I suppose even the most fruitless research is worth doing, because the answers we need might turn up in the most unexpected places,

Read more : Familial influences and MS. | Views : 1001 | Replies : 0 | Forum : General Discussion

Estriol trial

Some news on a phase II trial of estriol in the US. I'm adding it to the pipeline, don't know why I hadn't done that already...

New Trial for MS Drug

January 29, 2007 - The Press-Enterprise - People living with multiple sclerosis have to use injections to help control the disease. The method is the only anti-inflammatory treatment available.

But a new clinical trial, which is seeking participants, may help women with MS get ...
Read more : Estriol trial | Views : 1772 | Replies : 3 | Forum : Drug Pipeline

More evidence on Cannabis for pain

Hopefully regulators around the world get their thumbs out and start approving cannabis in whatever form for MS-related pain.

Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain.

Curr Med Res Opin. 2007 Jan;23(1):17-24.
Iskedjian M, Bereza B, Gordon A, Piwko C, Einarson TR.
PharmIdeas Research & Consulting Inc., Oakville, ON, Canada; PharmIdeas USA Inc., Charlotte, NC, USA.

OBJECTIVE: Debilitating pain, occurring in 50-70% of multiple sclerosis (MS) patients, is poorly understood and ...
Read more : More evidence on Cannabis for pain | Views : 2085 | Replies : 12 | Forum : General Discussion

Trial progress update

They seem to be enrolling people quickly...

Opexa Achieves Midpoint in Patient Admissions in Phase IIb Trial of Tovaxin for Multiple Sclerosis

Jan 30/2007 - BUSINESS WIRE - Opexa Therapeutics announced today that it has admitted the first 75 patients in its 150-patient Phase IIb clinical trial of Tovaxin in multiple sclerosis. Enrollment is expected to be completed by mid-2007. There are currently 34 trial sites in the U.S., all of which are actively recruiting ...
Read more : Trial progress update | Views : 1697 | Replies : 1 | Forum : Tcelna (Tovaxin)

Peace Like a River - Leif Enger

I can tell after only 100 or so pages that this is one of those books that's going to make me want to be a better person. Has anyone else read this book?
Read more : Peace Like a River - Leif Enger | Views : 3340 | Replies : 2 | Forum : Reading Nook


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