Hello, I'm another newbe to this site. Diagnosed in 2003, (wheelchair dependent). MD's with 2 opinions, one says RRMS now SPMS and the other says PPMS. I have tried all CRAB's, none work. I am now approved for Tysabri and should get 1st infusion soon. This is the best MS site I have found. A lot of good info here and I am looking forward to continued communication and new friendships.