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MBP8298 update

This sounds promising, although they don't provide much information here...

BioMS Medical's MBP8298 Shows Five-year Delay of Disease Progression in Patients with Multiple Sclerosis

March 7, 2006- BioMS Medical today announced that its proprietary drug candidate MBP8298 delayed disease progression for five years in progressive MS patients with HLA-DR2 or HLA-DR4 immune response genes.

Treatment and follow-up of patients from a phase II clinical study demonstrated that patients in this DR2 and DR4 responder group, ...
Read more : MBP8298 update | Views : 1286 | Replies : 1 | Forum : Drug Pipeline

MBP8298 Encouraging Results

Very encouraging results for disease progression from its phase II study! Hopefully this pans out with the phase II/III which they are now enrolling.

Original link: ... .html?.v=1


BioMS Medical's MBP8298 shows five-year delay of disease progression in patients with multiple sclerosis
Tuesday March 7, 8:55 am ET

-Results to be presented at the American Academy of Neurology April 4, 2006-
Toronto Stock Exchange Symbol: MS
Read more : MBP8298 Encouraging Results | Views : 1135 | Replies : 0 | Forum : Drug Pipeline

Difference Between statins

I was wondering if anyone has changed between the statins and noticed a difference in their effectiveness?

The ones I know of are:
atorvastatin (Lipitor)
fluvastatin (Lescol)
lovastatin (Mevacor)
pravastatin (Pravachol)
simvastatin (Zocor)
rosuvastatin (Crestor)

I just read an article at which basically states that lipitor is better than pravachol for anti-inflamitory effects.

He thinks that inflammation in the walls of the coronary arteries is behind many heart events and that Lipitor has ...
Read more : Difference Between statins | Views : 19477 | Replies : 47 | Forum : Statins

Patient Registry for Tysabri

An FDA briefing document was released today that recommends a mandatory patient registry for Tysabri users. In August 2005 the FDA mandated an electronic registry for all patients & physicians using Accutane, and it was just announced last week that it is up and running. Hopefully a Tysabri registry won't take as long to implement.
Read more : Patient Registry for Tysabri | Views : 2305 | Replies : 6 | Forum : Tysabri (Antegren or Natalizumab)


Health Research Associates invites you to participate in a research study to test questionnaires that are designed to assess how patients are affected by MS. The questionnaire packet would be mailed to you on two occasions, 2 weeks apart,
in a self-addressed stamped envelope.

If you choose to participate, you will earn $60 for completing both questionnaire packets.

This study does not involve medication, or a change in your current treatment.

For more information please ...
Read more : MS RESEARCH QUESTIONNAIRE | Views : 1090 | Replies : 0 | Forum : General Discussion

Conflicts of interest

This one is from the BCP site.


Five of the eleven scientists so far selected to judge the safety of the new multiple sclerosis drug Tysabri have financial ties to either the drug's sponsors, Biogen and Elan Pharmaceuticals, or their competitors. The Food and Drug Administration's Peripheral and Central Nervous System Drugs Advisory Committee will meet March 7 to reconsider Tysabri, ...
Read more : Conflicts of interest | Views : 1856 | Replies : 4 | Forum : Tysabri (Antegren or Natalizumab)

Testimony by Dr John Richert

A couple of weeks ago I posted part of an e-mail I had received from Dr John Richert, Vice Presdient of Research at the NMSS.

Attached is his testimony to the FDA about Tysabri.

Apologies if it has already been posted.

Ian ... timony.asp
Read more : Testimony by Dr John Richert | Views : 2205 | Replies : 4 | Forum : Tysabri (Antegren or Natalizumab)


I have previously posted articles relating to Neuren Pharmaceuticals. Much of their research focuses on neuro-protection. Their website states that:

"The compounds developed by Neuren have application not only to acute brain injuries associated with stroke, cardiopulmonary bypass surgery (CPB) and traumatic brain injury but also in chronic neurological conditions such as Alzheimer's Disease, Parkinson's Disease and Multiple Sclerosis".

Their first key drug, Glypromate, is in Phase 2 trials (with the US Army). The company ...
Read more : NNZ-2566 | Views : 1218 | Replies : 0 | Forum : Drug Pipeline

Wall Street Journal Editorial Today

Long URL but it should work for a week: ... TYwWj.html

Refers to Erbitux and Tysabri
Read more : Wall Street Journal Editorial Today | Views : 1441 | Replies : 1 | Forum : Tysabri (Antegren or Natalizumab)

vitamin B

I have not been able to find any discussion on ThisISMS with regards to multiple sclerosis and vitamin B (that's B as in Bromley come back). I did find a few references through Google scholar and they seem to be somewhat contradictory. I was wondering if anyone has looked into this, particularly vitamin B12. The articles I found were:
Reynolds EH, 'Multiple sclerosis and vitamin B12 metabolism' J Neuroimmunol 1992 Oct; 40(2-3):225-30.
Kira J, et ...
Read more : vitamin B | Views : 1517 | Replies : 3 | Forum : General Discussion


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