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Progressive (and RR) trial seeking participants - EBV based

The following trial is currently enrolling for SP, PP and RR subjects. Its based off of the work by Prof Pender regarding EBV.

I know in Sydney Australia they are still looking for participants. I also know that they are willing to adjust your treatment and wait if you are excluded by your current DMD. The criteria have and will possibly change, so call. They did sound pretty fixed on the less than 65yo one ...
Read more : Progressive (and RR) trial seeking participants - EBV based | Views : 477 | Replies : 0 | Forum : Drug Pipeline


2018 study: diet/disease correlation in EAE

Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model
https://www.wageningenacademic.com/doi/ ... M2017.0116

Multiple sclerosis (MS) is a metabolically demanding disease involving immune-mediated destruction of myelin in the central nervous system. We previously demonstrated a significant alteration in disease course in the experimental autoimmune encephalomyelitis (EAE) preclinical model of MS due to diet. Based on the established crosstalk between ...
Read more : 2018 study: diet/disease correlation in EAE | Views : 373 | Replies : 0 | Forum : Diet


Cryotherapy thoughts?

Hi all.

Anyone here do cryotherapy? What is your experience/thoughts?

Thank you!
Read more : Cryotherapy thoughts? | Views : 528 | Replies : 0 | Forum : Regimens


Chiropractic care for MS for dummies?

Hi all. I have read through some threads, but don't usually understand what people are referring to, and I'm wondering if someone can direct me to info about chiropractic care for MS in general.

My husband has PPMS, and is not taking any medication at all (for about a year), and has been on the Wahl's diet for about 2 years. We are interested in learning how chiropractic care might help him.

Thank you!
Read more : Chiropractic care for MS for dummies? | Views : 505 | Replies : 2 | Forum : Chiropractic Treatment


How did your walking issues start? Trouble with walking

Hi All,

I have been having issues with walking over the last 6-8 months. The main symptoms started when I walked 6k's or more, then slowly the symptoms became more obvious walking less distance, to now after about 1.5k's it starts. The issue is very heavy weak legs, like they are full of lead, numb feet and I can't seem to control my legs, like my brain and legs are not connected, with steps getting ...
Read more : How did your walking issues start? Trouble with walking | Views : 515 | Replies : 7 | Forum : General Discussion


Cerebral Blood Flow Changes in Multiple Sclerosis

Cerebral Blood Flow Changes in Multiple Sclerosis and Neuromyelitis Optica and Their Correlations With Clinical Disability.

https://www.ncbi.nlm.nih.gov/pubmed/29780351

Abstract

Distinguishing relapsing-remitting multiple sclerosis (RRMS) and neuromyelitis optica (NMO) is clinically important because they differ in prognosis and treatment. This study aimed to identify perfusion abnormalities in RRMS and NMO and their correlations with gray matter volume (GMV) atrophy and clinical parameters. Structural and arterial spin labeling MRI scans were performed ...


red blood cells have altered metabolism

red blood cells have altered metabolism

https://search.proquest.com/openview/25 ... 750&diss=y

Glucose transporter 1 (GLUT1) is the main glucose transporter on RBCs, and all metabolism within theRBC involves glucose.RBC GLUT1 content was used as a measure of RBC metabolism, andelevated RBC GLUT1 content is proposed to be associated
with increased cell metabolism.RBCs obtained from MS patients contained 23.3± 4.8% more GLUT1 than control RBCs, while T1D RBCs
contained 23.6± 4.2% less ...




new biomarker linked to blood flow

Quote: "The glycocalyx (GLX) is carbohydrate-rich outer surface of the blood vessel wall and is the first interaction between the blood and the vessel. We hypothesized that cleavage of the GLX may be an early stage predictor of immune attack, blood-brain barrier (BBB) breakdown, and disease severity in MS".

Detection of glycan shedding in the blood: New class of multiple sclerosis biomarkers?

https://www.frontiersin.org/articles/10 ... 4/abstract

Introduction: Multiple Sclerosis ...


impaired cerebral perfusion in MS

Long paper about general brain perfusion, but deals with MS at the end:

http://journals.sagepub.com/doi/pdf/10. ... 1918774800

Extracted from the article:

Brain perfusion in MS

In patients with MS, cerebral hypoperfusion was first observed about 30 years ago and it has become evident now that reduced cerebral perfusion, likely due to NVU malfunction and involving both the gray and white matter, is an integral feature of MS pathology. These findings ...


 

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