This Is MS Multiple Sclerosis Community: Knowledge & Support

**Posted:** Tue Jun 11, 2013 5:39 am

Hi all, I'm a newbie here... I take 30mg of Vyvanse (lisdexamphetamine) for adult ADD, diagnosed 2011, been on it for a month. My MS was diagnosed 2009. I have been blessed with a very mild course, and haven't had a relapse since my dx 2009. But Vyvanse is making me very hot and sweaty and now I'm having 'pseudo' exacerbations (I think) because of the heat vyvanse generates inside me, in conjunction with the ...

**Posted:** Tue Jun 11, 2013 2:52 am

Here's an interesting paper. It shows that several zinc ion binding genes are associated with a more progressive disease outcome. For example, in progressive patients, KLF4 is upregulated. In contrast, another zinc ion binding gene, S100B, is downregulated. I believe that this paper illustrates that the role of zinc binding proteins in MS progression is complex and not easily categorized. The full paper is freely available.

Zinc-ion binding and cytokine activity regulation pathways predicts outcome ...

**Posted:** Tue Jun 11, 2013 1:41 am

GSK inquiry reports signs of possible data fabrication in multiple sclerosis paper

An inquiry by the British pharmaceutical company GlaxoSmithKline (GSK) into allegations of possible data fabrication in a 2010 Nature Medicine paper regarding the role of specialized T cells in autoimmune disease has found what it sees as evidence of misconduct. Concerns regarding the paper surfaced last week, when news sources reported that the company had begun investigating the research conducted for the study ...

**Posted:** Mon Jun 10, 2013 8:11 pm

Quote:

CHICAGO --- A phase 1 clinical trial for the first treatment to reset the immune system of multiple sclerosis (MS) patients showed the therapy was safe and dramatically reduced patients’ immune systems’ reactivity to myelin by 50 to 75 percent, according to new Northwestern Medicine research.
...
In the trial, the MS patients’ own specially processed white blood cells were used to stealthily deliver billions of myelin antigens into their bodies so their immune ...

**Posted:** Mon Jun 10, 2013 2:32 pm

http://www.medscape.com/viewarticle/805565

Quote:

Still addressing delegates during the joint CMSC/ACTRIMS meeting, Dr. Rae-Grant emphasized the importance of not dismissing the possibility that CCSVI really does work.

"What if we're missing something? What if there is a vascular piece to this? What if there's a subset in which this means something? What if we're throwing the baby out with the bathwater?" And what if, down the road, it becomes clear that "we ...

**Posted:** Mon Jun 10, 2013 2:22 pm

... look at blood and csf flow in and out of the cranial vault?

Dr. Rosa in New York is mentioned often as he is involved in a specific study. I wish I could see Dr. Rosa simply as patient (not in the study), but travel time and expense prevent it from my home base.

Does anyone know of any others on this forefront we could add to the list? I believe there are Fonar ...

**Posted:** Mon Jun 10, 2013 9:46 am

Seemed to get a huge infection, I woke up this morning looked in the mirror and both eyes were all crusty and pink. I never get sick and i've only had pink eye once in my life, So I was wondering if i would be more likely to contract other diseases while on LDN.

**Posted:** Mon Jun 10, 2013 8:23 am

just want to show what health Canada is like .

Health Canada blocks dying patients from access to drug

Specialist 'appalled and angry' with federal agency

http://www.cbc.ca/news/canada/british-c ... enied.html

**Posted:** Mon Jun 10, 2013 3:37 am

Potential MS drug RPC1063 meets primary objective in TQT study

Receptos, Inc. said its oral, once daily, selective and potent S1P1R modulator RPC1063 completed a thorough QT/QTc or TQT study of herart's electrical conduction system and met its primary objective. The company also obtained special protocol assessments or SPA from FDA for Phase 3 Trials in Relapsing Multiple Sclerosis.

RPC1063 is currently in development for autoimmune indications and being studied in randomized Phase 2 trials ...

**Posted:** Sun Jun 09, 2013 7:43 pm

I do not claim to know the full extent of where this is heading, but thought someone else may find it of interest if only as a (possible) extra fact to know. I searched the site, and found no other references to the study. Basically, carnosinase is pretty low in MS compared to normals and even other CNS diseases.

Normals - 161
Epilepsy - 148
MND - 155

Parkinsons - 109
Multiple Sclerosis - 82.5 ...

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