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Rapid depletion of B lymphocytes by ultra-low-dose rituximab delivered intrathecally
Objective: We are conducting an open-label phase 1b study on the efficacy of intrathecal (IT) administration of rituximab, provided via an Ommaya reservoir, for the treatment of progressive multiple sclerosis (PMS). The objective of this initial study was to monitor B lymphocytes in peripheral blood (PB) and CSF from the first 10 patients 1 year ...
"These correlations suggest that inflammation has a critical role in the degradation of cerebral vasoregulation in the milieu of chronic hyperglycemia regardless of glycemic control," they added.
They said their findings also suggest that endothelial problems may develop early in the course of hyperglycemic damage, before any structural changes ...
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