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Pathological mechanisms in progressive multiple sclerosis

Summary
A better understanding of the pathological mechanisms that drive neurodegeneration in individuals with multiple sclerosis is needed to develop therapies that will effectively treat patients in the primary and secondary progressive stages of the disease. We propose that the inflammatory demyelinating disease process in early multiple sclerosis triggers a cascade of events that lead to neurodegeneration and are amplified by pathogenic mechanisms related to brain ageing and accumulated disease burden. Key elements driving neurodegeneration ...
Read more : Pathological mechanisms in progressive multiple sclerosis | Views : 274 | Replies : 0 | Forum : General Discussion


RE US TRIALS FOR HSCT PUBLISHES INTERIM RESULTS

HI friends A clinical trail conducted in the USA know as HALT-MS has published the interim results
please read more http://www.msra.org.au/trial-hsct-ms-interim-results
regards
seeva
Read more : RE US TRIALS FOR HSCT PUBLISHES INTERIM RESULTS | Views : 268 | Replies : 0 | Forum : Stem Cells


New chemical entity for optic neuritis and MS in development

Bionure, Inc. a California-based late-preclinical drug development company, today announced that it has entered into a Sponsored Research Agreement with the US National Multiple Sclerosis Society through Fast Forward, its commercial research subsidiary aimed at accelerating the development of new and improved therapies for MS. Under this agreement, Fast Forward will provide funding to Bionure for the late-preclinical development of BN201 to enable IND filling to support the Phase 1 clinical study in Acute Optic ...
Read more : New chemical entity for optic neuritis and MS in development | Views : 240 | Replies : 0 | Forum : General Discussion


Worldwide HSCT Roadmap and Funding

My main question is who out there is thinking about how to bring this treatment to more people? And if there isn't a formal organization or research center, then perhaps the MS community of patients and caregivers who are interested in HSCT perhaps can begin to get this on the table.

In summary, at this time the success of HCST and related treatments has appeared to hit the mainstream; or at least the news of ...
Read more : Worldwide HSCT Roadmap and Funding | Views : 286 | Replies : 3 | Forum : Stem Cells


HALT-MS HSCT Trial

Experimental MS treatment halts disease ‘in its tracks’
http://seattletimes.com/html/localnews/ ... lsxml.html

A Seattle man is among two dozen MS patients in a promising clinical trial that found high-dose immune-suppressing drugs and stem-cell transplants may stop the progress of the disease in those who've failed usual care.

    “The opportunity I was given now feels like a gift,” said Kearny, who was treated in December 2009 and has seen no progress ...
Read more : HALT-MS HSCT Trial | Views : 274 | Replies : 1 | Forum : Stem Cells


Inclined Bed Warning

On November 29, 2014 I published a blog entry titled “Progressive MS and the Spine” on this site. I entered the same post on Thisisms.com the same day. In response Stillhaha wrote

“Thanks for posting this.
Personally, I keep finding excuses (foolish, impractical ones) to avoid trying Inclined Bed Therapy for my PPMS. Your post makes me think about CSF and if I can repair things.”

I decided to try an Inclined Bed as well, ...
Read more : Inclined Bed Warning | Views : 356 | Replies : 1 | Forum : General Discussion


RE NEW HOPE FOR MS SUFFERERS

HI FRIENDS PLEASEW READ THIS
https://www.facebook.com/photo.php?fbid ... =1&theater
regards
seeva
Read more : RE NEW HOPE FOR MS SUFFERERS | Views : 323 | Replies : 0 | Forum : Stem Cells


Ashton Embry about the misconducts of some teams

The most recent negative Canadian CCSVI study, lead by University of British Columbia neurologist Dr. Anthony Traboulsee and published in The Lancet, did not utilize the original scientific protocol of Dr. Paolo Zamboni.
http://www.thelancet.com/journals/lance ... X/abstract

This new study displayed even further arrogance and audacity, by deviating from all other published venous and arterial studies, utilizing a false criteria to assess jugular vein stenosis.

Stenosis is routinely measured by ...


Mri tomorrow

My symptoms started April 2014 with a headache only on the left side of my head. left side of face tingling and dizziness (or vertigo) dont really know the difference. This episode lasted for a little more than a month. i had an mri that showed. Brain lesion on left side of my brain. I am extremely claustrophobic so I only completed part of the test. The symptoms subsided in about 5 weeks so I ...
Read more : Mri tomorrow | Views : 273 | Replies : 4 | Forum : Undiagnosed


Collaboration aims to reduce neurodegeneration in MS

University of Edinburgh and Genzyme collaboration aims to reduce neurodegeneration in MS

University of Edinburgh scientists are set to work with leading biotechnology company Genzyme, a Sanofi company, to carry out drug discovery research that could reduce neuron damage in the brain.

The collaboration - facilitated by Edinburgh BioQuarter's Business Development team - will focus on identifying therapeutic candidates capable of promoting remyelination and reducing neurodegeneration, mostly in relation to Multiple Sclerosis (MS)............ Read More ...
Read more : Collaboration aims to reduce neurodegeneration in MS | Views : 287 | Replies : 0 | Forum : General Discussion


 

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