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MedDay’s Phase 3 Trial - impact on Optic Neuritis failed

I just saw this even though it is from a few months ago - hope it is not a duplication on TIMS.

MedDay’s MD-1003 PHASE III Optic Neuritis Trial Results For MS


A clinical trial of MedDay’s promising medication MD-1003 in a study of the drugs impact on Optic Neuritis failed to meet its endpoint in outperforming placebo towards improving vision for people who have multiple sclerosis.

Here is a link to the article ...
Read more : MedDay’s Phase 3 Trial - impact on Optic Neuritis failed | Views : 308 | Replies : 1 | Forum : Drug Pipeline


Tecfidera Fertility for Men

Hi, I'm hoping to get some information from people who may know information or be in a similar position. My husband has been diagnosed with MS and is due to start Tecfidera soon. We want to try for another baby but we are worried as we don't know if the drug can cause infertility or birth defects. We have asked the MS nurse assigned to him but she can't give us a real answer on ...
Read more : Tecfidera Fertility for Men | Views : 293 | Replies : 2 | Forum : General Discussion


More evidence that gut bacteria may play a key role in MS

More evidence that gut bacteria may play a key role in MS

Two new studies from the U.S and Germany have added to growing evidence that gut bacteria may play a role in the brain inflammation caused by Multiple Sclerosis...Read more - http://www.ms-uk.org/more-evidence-gut-bacteria-may-play-key-role-ms
Read more : More evidence that gut bacteria may play a key role in MS | Views : 303 | Replies : 0 | Forum : General Discussion


Vascular hypoperfusion in acute optic neuritis

Vascular hypoperfusion in acute optic neuritis is a potentially new neurovascular model for demyelinating diseases.

Source: https://www.ncbi.nlm.nih.gov/pubmed/28926646

Abstract
PURPOSE:

Optic neuritis is highly correlated with multiple sclerosis and is a major cause of acute visual loss and long-term neuronal degeneration. Primary cerebral hypoperfusion has been reported in brain demyelinating diseases. This study investigated whether peripapillary perfusion is changed in patients with acute optic neuritis (AON).
METHODS:

This three-year cohort ...


Biomarkers for response to therapies

Having several disease modifying drugs available, is interesting to know what kind of response is expected for each one in a given patient.

Pharmacogenetic Biomarkers to Predict Treatment Response in Multiple Sclerosis: Current and Future Perspectives
Source: https://www.hindawi.com/journals/msi/2017/6198530/

The review only shows genes associated with responses to interferons, glatimer acetate and mitoxantrone. Could be interesting, anyway.
Read more : Biomarkers for response to therapies | Views : 279 | Replies : 2 | Forum : MS Etiology and Pathogenesis


microRNA miR-155 dysregulation

Authors of the article say that is not only a biomarker, but also a target for intervention. I put it here in biomarkers just to be conservative.

miR-155 Dysregulation and Therapeutic Intervention in Multiple Sclerosis.

Abstract

microRNAs play a fundamental role in the immune system. One particular microRNA, miR-155 plays a critical role in hematopoietic cell development and tightly regulates innate and adaptive immune responses in response to infection.

However, its dysregulation, more specifically its ...
Read more : microRNA miR-155 dysregulation | Views : 236 | Replies : 0 | Forum : MS Etiology and Pathogenesis


Nuro wants another MRI

I just had one 2 months ago and now she wants another to see if my Avonex is causing lesions.
Is this something on the common side for nuros to do? It's a good thing right now my ins is paying for my MRI's other wise I would of said hell no!
Read more : Nuro wants another MRI | Views : 496 | Replies : 0 | Forum : Avonex


CSF testing and other questions

I'm a 39 year old female, with a 4 year old and a 9 month old.
I've had an MRI that shows T2 hyper-intensities in 2 of the 4 areas of the brain that may indicate MS. However, both neurologists I have seen say that I do not have the traditional history or current symptoms of someone with MS, so I have had a CSF test done (awaiting results - ugh!) and I will go ...
Read more : CSF testing and other questions | Views : 413 | Replies : 1 | Forum : Undiagnosed


looking for a clinic to do MSCT

hi guys
i am from montreal(canada) and i am searching for a facility where i can do MSCT, but not too far from home. it will be nice if it is in vermont state, or the begining of new york state ( albany area for example).
any help or advice are welcome.
thanks in dvance and sorry for the faults, i have MS :-)
Read more : looking for a clinic to do MSCT | Views : 335 | Replies : 0 | Forum : Stem Cells


Association of Developmental Venous Anomalies with MS

Association of Developmental Venous Anomalies with Demyelinating Lesions in Patients with MS

Source: https://www.ncbi.nlm.nih.gov/pubmed/28912286

Abstract

We present 5 cases of demyelination in patients diagnosed with multiple sclerosis that are closely associated with a developmental venous anomaly.

Although the presence of a central vein is a known phenomenon with multiple sclerosis plaques, demyelination occurring around developmental venous anomalies is an underreported phenomenon.

Tumefactive demyelination can cause a diagnostic dilemma because ...


 

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