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Anti-NMDA may explain some MS mental deficits

Prematurely severe cognitive impairment in multiple sclerosis patients could be an effect of autoantibodies against the N-methyl-D-aspartate (NMDA) receptor complex, with natalizumab (Tysabri) withdrawal a potential contributor, a case report from Germany suggested.

In an MS patient who had to be confined to a nursing home at age 39 because of cognitive deficits amounting to dementia, immunoglobulin G-type antibodies to the NMDA receptor's NR1 subunit were found in cerebrospinal fluid samples, according to Klemens Ruprecht, ...
Read more : Anti-NMDA may explain some MS mental deficits | Views : 162 | Replies : 0 | Forum : Tysabri (Antegren or Natalizumab)


Acne and MS connected?

Any connection between skin acne and MS?

I break out BADLY after every time I have a relapse. I thought this was (obviously) due to the steroid treatments but this last time I did not go on a steroid treatment. Although here I am again, very badly broken out. It is the worst on my back.

My skin is never super clear but it is insanely bad right now.

Is this just random or what? ...
Read more : Acne and MS connected? | Views : 193 | Replies : 1 | Forum : General Discussion


Symptoms beginning to worry me

Hi all, I just joined today to share...

I haven't been to my GP yet about symptoms as they are now. In the past I've been diagnosed with a "text-book" case of Mono in 2011 (when I was 26) and, more recently, general anxiety and ADD in 2012.

Since having mono, I never really felt the same, but for the past few months things have been getting worse. The symptoms I have include:

  • Extreme fatigue ...
Read more : Symptoms beginning to worry me | Views : 259 | Replies : 8 | Forum : Undiagnosed


24 treated, 24 with an end to symptoms

A lot of people state that Immune issues are not the route of the problem but the study about to be released will challenge that. The immune system may not be the cause but it does the damage. Remove that and what is MS?

http://www.ottawacitizen.com/health/Ott ... story.html
Read more : 24 treated, 24 with an end to symptoms | Views : 607 | Replies : 9 | Forum : General Discussion


Iron supplements and MS dx

I hope I am posting this in the correct forum. Has there ever been conducted to ask how many patients Dx with MS have been on Iron Supplements at some point in life? Any light u can shed on this would be great. I have been searching for information to no avail, but findings on the effects of iron reduction therapy are rather interesting in patients with MS. Curious if supplements of iron have been ...
Read more : Iron supplements and MS dx | Views : 178 | Replies : 2 | Forum : Chronic Cerebrospinal Venous Insufficiency (CCSVI)


Magnesium the neglected mineral

The People's Pharmacy recently interviewed Dr. Carolyn Dean author of The Magnesium Miracle discussing the benefits of magnesium and proper test levels.

http://www.peoplespharmacy.com/2014/11/ ... d-mineral/

The full interview will be freely available for the next 6 weeks.

http://traffic.libsyn.com/peoplespharmacy/PP-969mag.mp3
Read more : Magnesium the neglected mineral | Views : 199 | Replies : 1 | Forum : Natural Approach


Anemone toxin inhibits KV1.3

The Alliance for Children's Therapeutics in collaboration with Dr. Anne Stevens of Seattle Children's Hospital and Kineta Biotech are developing a synthetic protein known as Shk-186. Based on a toxin from the Sun Anemone, Shk-186 inhibits the potassium channel KV1.3 in effector memory T cells and blocks the proinflammatory cytokine cascade leading to autoimmunity.

http://www.childrenstherapeutics.org/treatments.html

http://www.kinetabio.com/autoimmune.html

http://www.seattlechildrens.org/researc ... evens-lab/ ...
Read more : Anemone toxin inhibits KV1.3 | Views : 160 | Replies : 0 | Forum : Drug Pipeline


Synthetic protein targets EBV

UW researchers at the Institute of Protein Design have developed a synthetic protein called BINDI which binds to the Epstein-Barr Virus (EBV) protein BHRF1 responsible for immortalizing cells. Inhibition of BHRF1, a BCL2 homologue, may prove to be a useful treatment for EBV related cancers and other conditions stemming from EBV.

http://www.ipd.uw.edu/designer-proteins ... cer-cells/

http://www.cell.com/cell/abstract/S0092 ... %2900613-8
Read more : Synthetic protein targets EBV | Views : 132 | Replies : 0 | Forum : Drug Pipeline


Dx rrms but very scared its ppms. Opinions needed.

Hello. I am new on this forum and I must say I am quite impressed with The overwhelming amount of information available here. I live in Ontario Canada. I'm a 39 year old male. I have sole custody of my 3 year old daughter from a previous relationship. I was married in the summer of 2013. And I'm a nervous wreck going through hell at the moment. I own a moving company that is well-established ...
Read more : Dx rrms but very scared its ppms. Opinions needed. | Views : 465 | Replies : 24 | Forum : Introductions


Why do hsct bloggers stop posting around the one year mark?

I'm still doing well from my rituxan treatment but hsct is on my radar for the future. I don't do Facebook so I can't log onto the hsct group there. The bloggers I follow have all stopped posting updates or deleted their blogs after about a year. What's up with that? Anyone on Facebook know if some are losing progress after year one? I hope not but...
Read more : Why do hsct bloggers stop posting around the one year mark? | Views : 320 | Replies : 3 | Forum : Stem Cells


 

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