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A board to discuss the Multiple Sclerosis modifying drug Rebif

CHMP gives positive opinion extended indication for Rebif

CHMP gives positive opinion for extended indication for Rebif® for patients with early signs Of MS


Merck Serono, a division of Merck KGaA, Darmstadt, Germany, announced today that it received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency (EMA), for its variation application to extend the indication of Rebif (interferon beta-1a), its leading treatment for relapsing forms of multiple sclerosis (MS). ...
Read more : CHMP gives positive opinion extended indication for Rebif | Views : 2756 | Replies : 0

MS markers match disability progression in Rebif study


Two surrogate markers commonly used in multiple sclerosis (MS) clinical trials are near-perfect measures of the effect of treatment with interferon, researchers reported.

In a statistical analysis of patients in a major clinical trial, the two markers -- T2 lesions seen on MRI and relapses -- accounted for all of the effect of interferon ß-1a on disease progression, according to Maria Pia Sormani, PhD, of the University of Genoa in Italy, and colleagues.

The ...
Read more : MS markers match disability progression in Rebif study | Views : 2411 | Replies : 0

rebif for me

Hello... I'm very new to the site and I usually don't share how I feel but here it goes! I was incarcerated six yrs ago and while in prison I experienced numbness they wrote it off as a stroke but this last year while at work I experienced the numbness again and after a week of being numb I went to my family dr. He said it looked like a stroke but did an mri ...
Read more : rebif for me | Views : 1837 | Replies : 6

Taking medicine during a relapse

I have been on Rebif for about a year. I realize relapse can be pretty random but chances are one is going to happen relatively soon. If I feel I am having a relapse, should i inject the medication during the exacerbation?
Read more : Taking medicine during a relapse | Views : 1770 | Replies : 1

rebif & hair loss

i was diagnosed june 1, 2011 & im in my 3rd month of rebif.. & ive been noticing my hair has been getting VERY thin on the top ]: im only 24 & im NOT okay with this! what can i do to help to help stop this? i have a dr appointment @ the end of the month. i really would like to stay on rebif because im used to it & dont want ...
Read more : rebif & hair loss | Views : 3077 | Replies : 5


I am on this rebif, was on beterseron, that was when I first got sick, now I have seizures and these interferons cause seizures, now not everybody will get them, but I have a primary brain lesion which is big, I have three others, but they are small. I took a break from this rebif, don't remember having any problems, was started back on it ASAP. The first night I took that shot, that morning ...
Read more : seizures | Views : 1852 | Replies : 0

Anyone with GOOD Experiences on Rebif??

My name is Amber, I was given my official diagnosis of RRMS yesterday.

They want to start me on Rebif, and I'd like to give it a chance. If it can do the things they say it does, it might be worth at least giving it a go, right?

I looked on these forums hoping to see some positive forums about the drug and every single one is "why I quit Rebif" and all ...
Read more : Anyone with GOOD Experiences on Rebif?? | Views : 11984 | Replies : 44

Merck KGaA submits Rebif extention application in Europe


Merck KGaA submitted an application to the European Medicines Agency or EMA to extend the indication of Rebif, its treatment for multiple sclerosis or MS. The company added that the requested label extension is for the use of Rebif in patients who have experienced a single demyelinating event, an early sign of the disease, and who are at high risk of converting to MS..... Read More - ... ageid/1901 ...
Read more : Merck KGaA submits Rebif extention application in Europe | Views : 1827 | Replies : 0

Interferon at first sign of MS delays progression


Starting interferon-beta-1a (Rebif New Formulation) immediately upon an episode of a clinically isolated syndrome delayed progression to full-blown multiple sclerosis, but once-weekly treatment was less effective than the standard dosing interval, a researcher said here.

A randomized, placebo-controlled trial called REFLEX showed that 62% and 76% of patients assigned to 44 mcg of interferon subcutaneously three times or once weekly, respectively, met 2005 McDonald criteria for MS after two years -- the study's primary ...
Read more : Interferon at first sign of MS delays progression | Views : 1834 | Replies : 0

My experience with ReBif

Sorry to purposely create a new post when there already is a header for such discussion. I just want to share my experience as it is still relatively new and evolving.

First, a little about me. I am a 30year old white male, born and raised from Windsor Ontario Canada. I have never smoked cigarettes, do not drink alcohol (I could count the times I have gotten drunk on one hand). Never done drugs. I ...
Read more : My experience with ReBif | Views : 2974 | Replies : 5


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