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Discussion of statins (Lipitor, Zocor, etc.) in the treatment of MS.

Some statins may help SPMS? Some statins do not help RRMS?

Hi,

I thought to start this topic as I'm trying to understand statins and if they can help, and whether I should pursue this with my doctors. I'm new to this forum . After reading through several posts I'm confused. There are some aspects that appear to make this harder to understand.

(1) MS Type: RRMS, SPMS, PPMS, PRMS. It seems that the impact of statins may ...
Read more : Some statins may help SPMS? Some statins do not help RRMS? | Views : 94 | Replies : 0


Statins, rituxan, and cd20

Stumbled upon this today. Statins may impair the binding of rituxan to cd20's by altering the shape of the receptor. http://journals.plos.org/plosmedicine/a ... ed.0050064

I wonder if the efficacy of statins for ms is dependent upon this cd20 interaction. Why? How?
Read more : Statins, rituxan, and cd20 | Views : 257 | Replies : 0


I take green/white tea and EGCG supplements with my Zocor

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http://home.ix.netcom.com/~jdalton/egcg-neorond-ms.pdf


jackD

I would have just posted the Abstracts but they are useless!!! These guys have "novel" brains!!!



1. J Neuroimmunol. 2007 Mar;184(1-2):17-26. Epub 2007 Jan 10.

Neurodegeneration in autoimmune demyelination: recent mechanistic insights reveal novel therapeutic targets.

Aktas O1, Waiczies S, Zipp F.
Author information:
1Institute for Neuroimmunology, Neuroscience Research Center, Charité -- Universitätsmedizin Berlin, Germany.

Abstract
Multiple sclerosis (MS) is the most common chronic demyelinating disease of the central nervous system (CNS) ...
Read more : I take green/white tea and EGCG supplements with my Zocor | Views : 933 | Replies : 2




Read this before taking statins for MS

I have just finished reading a book by Dr. Stephen Sinatra (a cardiologist) and Dr. Jonny Bowden called "The Great Cholesterol Myth." I think that anybody considering using statins, whether for MS or for any other reason, should read it. The book discusses many of the side effects caused by statins. For example, it states that cholesterol is important for the healthy functioning of the brain and that if total cholesterol drops lower than 165 ...
Read more : Read this before taking statins for MS | Views : 4396 | Replies : 15


Statin may slow progressive MS

Image

High-dose simvastatin (Zocor) significantly reduced brain atrophy and slowed advancement of disability for 2 years in patients with secondary progressive multiple sclerosis, researchers said here.

In a 140-patient randomized trial, patients receiving 80 mg/day of simvastatin had an annualized rate of brain volume loss of just 0.298% compared with 0.589% among those given placebo (P=0.003), reported Jeremy Chataway, MA, PhD, of University College London in England.

Significant reductions in disability progression, as measured by ...
Read more : Statin may slow progressive MS | Views : 1896 | Replies : 1


Health hazards with statins

Naturally, I was particularly interested in the statins/diabetes connection. Apparently, statins raise blood sugar, increase insulin levels; chronic elevated insulin levels increase inflammation:

http://articles.mercola.com/sites/artic ... _DNL_art_1
Read more : Health hazards with statins | Views : 1853 | Replies : 1




No Benefit of Simvastatin

Read more : No Benefit of Simvastatin | Views : 1877 | Replies : 1


Statins have detrimental effects on remyelination in MS

Image

Simvastatin interferes with process outgrowth and branching of oligodendrocytes.

Abstract

Statins have attracted interest as a treatment option for multiple sclerosis (MS) because of their pleiotropic antiinflammatory and immunomodulatory effects.

However, contradictory results have been described when they are applied to oligodendrocytes (OLGs), the cell type predominantly affected in MS. In this study we focus on the in vitro effect of statins on process outgrowth in OLN-93 cells, a well-characterized OLG-derived cell line, and ...
Read more : Statins have detrimental effects on remyelination in MS | Views : 1904 | Replies : 0


 

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