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Discuss Tecfidera (BG-12, dimethyl fumarate) as an oral treatment for multiple sclerosis.

FDA adds rare brain infection link to Tecfidera label

FDA adds rare brain infection link to MS drug Tecfidera labelling

The death from a serious brain infection of a patient taking Biogen Idec's big-selling oral multiple sclerosis therapy Tecfidera has prompted an update to the drug's label in the US.

The FDA issued a notice describing the case of a patient on Tecfidera (dimethyl fumarate) who developed progressive multifocal leukoencephalopathy (PML), the same condition that caused Biogen Idec's injectable MS therapy Tysabri (natalizumab) to ...
Read more : FDA adds rare brain infection link to Tecfidera label | Views : 401 | Replies : 1


Tecfidera vs no med

Hello everybody. Thanks for reading my post.
I was diagnosed with MS 7 years ago after an optic neuritis which was treated with esteroids which help me to a full recovery. I had
another flare up in March this year which affected the sensitivity of both my legs but I fully recoverd after a month. I have NEVER used any medication. I feel good, have no signs of tiredness whatsover, I swim on a daily ...
Read more : Tecfidera vs no med | Views : 372 | Replies : 0


Tecfidera or flare-up?

I am on week three of Tecfidera. Two nights ago, I started noticing an area above my right knee on my inner thigh that was burning (like the feeling of someone holding a lit match next to my skin). This sensation isn't new to me but it is new while being on medication (never had this while I was on Tysabri). The area has now become bigger so now the sensation is on most of ...
Read more : Tecfidera or flare-up? | Views : 356 | Replies : 0


Copaxone to Tec

I have been on Copaxone for almost 2 years, along with many other lifestyle changes and i have noticed a reduction in relapses and general well being. I go to the gym regularly following various power-lifting routines and have gained 17lbs in a year, mostly muscle, and that is an issue... My bodyfat is 10% and I can no longer inject in my arms or legs which makes the little bit of fat around my ...
Read more : Copaxone to Tec | Views : 501 | Replies : 3


Nervous about starting Tecfidera

I finally got my Tecfidera starter pack after over a month of waiting. I plan to start it tomorrow or Monday, but I am a little nervous. I will be traveling to Peru next month for Christmas - which gives me about 6 weeks to be on the medication before I go. I'm worried the side effects won't have diminished by then and have been considering waiting until I get back from my trip to ...
Read more : Nervous about starting Tecfidera | Views : 324 | Replies : 2


does it get worse before getting better

I think I've mentioned this here before, but I think I was alone on this. I'm still trying to make Tec work, and am on my sixth attempt. What happens is about a week into the half dose, I start getting all kinds of new MS symptoms. These disappear when I discontinue the drug. For example, I just started getting the hug tonight--never had that before. Or I'll start feeling wobbly on my feet, or ...
Read more : does it get worse before getting better | Views : 432 | Replies : 3


First 3 months

Hi everyone,

I'm 28 years old and I was diagnosed with MS this past July. I have the common form with times of regression. I immediately started taking Tecfidera. Side effects I have experienced have been flushing accompanied by itching (flushing can be intense), weight gain, bloating, stiffness of joints (I believe due to bloating), and intense menstrual cramps.
The pain experienced before and during my cycle is the worst side effect. The first 2 ...
Read more : First 3 months | Views : 362 | Replies : 0


first PML case on tecfidera

Caveat emptor

http://www.reuters.com/article/2014/10/ ... 9720141022

Biogen reported the first case of progressive multifocal leukoencephalopathy (PML) in a Tecfidera patient, who had been part of a clinical trial and was taking the drug for 4-1/2 years.

The patient, who died of pneumonia, had been suffering severe lymphopenia, a low white blood cell condition, for more than three years, which Biogen said was a risk factor for developing PML.

Biogen, which ...
Read more : first PML case on tecfidera | Views : 1550 | Replies : 4


Elevated Liver Numbers!

I've been on Tec for 4 weeks, 3 weeks at the standard dose and I've had a few mishaps with my labs. Initially, when I got labs to start the medication I had a borderline ANC of 1.8 which was concerning since Tec drops WBC counts. My neuro is being especially cautious and has ordered labs at 1,3, and 6 months so I just went in for my one month draw yesterday. The good news ...
Read more : Elevated Liver Numbers! | Views : 528 | Replies : 1


dry mouth?

I have been on this med for 4 months and the flushing only comes once in a while. But I have had extreme dry mouth ever since I started the medication. It usually starts within 3-4 hours of taking my first dose of the day. Does anyone else have this? If so what can I do to get rid of it?
Read more : dry mouth? | Views : 368 | Replies : 2


 

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