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Discuss Tecfidera (BG-12, dimethyl fumarate) as an oral treatment for multiple sclerosis.

Do fumarates change into fumaric acid in vivo?

Need brainier folks than I for this one...

Dimethyl fumarate and clemastine fumarate are both alleged to have potential beneficial effects on some pwms for different reasons or unknown reasons. Dimethyl might reduce relapses. Clemastine might contribute to remyelination.

IF fumarates are changed into fumaric acids by our bodies, might it be fumaric acids that are helping?

Fumaric acid is produced in our skin when it is exposed to sunlight. Maybe vitamin d is just ...
Read more : Do fumarates change into fumaric acid in vivo? | Views : 43 | Replies : 0


Ibuprofen instead of aspirin for flushing

Hi, I was wondering if anyone has tried ibuprofen instead of aspirin to help ward off flushing. I've been taking ibuprofen for years for arthritis and general body pain, and wondered if this could be taking instead of aspirin.
I asked my doctor and also researched ibuprofen for the flushing side effect from Tecfidera, and only came across taking aspirin for this.

I started taking Tecfidera on Sunday. On day one, I took one 325mg ...
Read more : Ibuprofen instead of aspirin for flushing | Views : 542 | Replies : 0


What was your first day like on Tecfidera?

Hi, this is my first day on Tecfidera. I was just wondering how others did on their first day on Tec. This might help others who have concerns or worries about what to expect.

My experience so far... after 30 minutes, my face started feeling very warm. Like, if the sun was on your face on a hot summer day. That feeling lasted for about 20-30 minutes, then went away. Now, 4 hours into my ...
Read more : What was your first day like on Tecfidera? | Views : 431 | Replies : 0


Dimethyl fumarate achieves no evidence of disease activity..

Dimethyl fumarate achieves no evidence of disease activity in MS patients

Data analysis of two previous trials has shown that a higher number of patients with relapsing remitting multiple sclerosis (RRMS) achieved no evidence of disease activity (NEDA), over a two year period, with delayed-release dimethyl fumarate (DMF) compared to a placebo...Read more - http://www.ms-uk.org/dimethyl-fumarate-achieves-no-evidence-disease-activity-ms-patients-210417
Read more : Dimethyl fumarate achieves no evidence of disease activity.. | Views : 451 | Replies : 1


Fever and wheezing on Tec **Update**

I'm on day 3 of taking three 120mg per day (two in the am, one in the pm).

I'm titrating very slowly because it's killing my stomach.

Anyway about 2 hours after the morning dose I started wheezing, bad enough that I can't lie down. I also have a dry cough.

I thought it could be reflux so I took some Gaviscon, which helped the tummy but not the breathing.

Now I have a headache, ...
Read more : Fever and wheezing on Tec **Update** | Views : 560 | Replies : 6


Bariatric surgery and Tecfidera

I am about to start Tecfidera, and I am currently on a waiting list for bariatric surgery (Roux en Y or possibly gastric sleeve).

This is a long shot, but has anyone else gone through this procedure while taking Tecfidera?

I feel like I'm walking into catastrophe. My neurologist is very uninformed about the surgery, which is fine except that he's quite nonchalant and not inclined to do any research to help me - yet ...
Read more : Bariatric surgery and Tecfidera | Views : 646 | Replies : 3


Always read the label – MS drug Tecfidera...

Always read the label – MS drug Tecfidera sites possible liver damage

Drug company Biogen has updated the possible side effects of MS drug Tecfidera, warning it may cause ‘significant liver injury’, which could require hospitalisation...Read more - http://www.ms-uk.org/always-read-label-%E2%80%93-ms-drug-tecfidera-sites-possible-liver-damage-260117
Read more : Always read the label – MS drug Tecfidera... | Views : 607 | Replies : 1


Tecfidera users: favour please?

I have a favour to ask - could someone please measure the size (length and width) of a 120 mg and 240 mg Tecfidera capsule?

I am having a heck of a time getting these measurements. I've asked by BioGen rep twice and she keeps giving me everything but.

Thank you!
Read more : Tecfidera users: favour please? | Views : 652 | Replies : 3


Tecfidera may limit visual problems for MS patients

Scientists who genetically silenced the transcription factor Nrf2 in a study of mice found it caused visual impairment and retinal ganglion cell (RGC) degeneration in MS...Read more - http://www.ms-uk.org/tecfidera-may-limit-visual-problems-ms-patients-190117
Read more : Tecfidera may limit visual problems for MS patients | Views : 565 | Replies : 0


Does it get better? Stomach pain & nausea

Hello,

I started Tecfidera on Oct. 30th, just finished second week of maintenance dose. I've had an iron stomach all my life, never had bowel problems - until now. I'm constantly nauseated, have the stomach pain others have described, and I'm constipated. I have no appetite and even experience stomach pain from drinking water.

I've read all the posts with the excellent suggestions, which I'm going to do my best to follow.

My question for ...
Read more : Does it get better? Stomach pain & nausea | Views : 969 | Replies : 4


 

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