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Discuss Tecfidera (BG-12, dimethyl fumarate) as an oral treatment for multiple sclerosis.

Fumaric salts, Biogen funds huge study. New "treatment&

Just tickled with some of the stuff that hits the inbox on a daily basis. Highly recommend all to sign up for google news alerts, with keywords multiple sclerosis and another one for ccsvi. It's like having a front row seat to the news cycle as it happens.

Fumaric salts have been used to treat psoriasis, and now, it appears the anti-oxidative effects that help that condition, also may help MS sufferers, and Biogen is ...
Read more : Fumaric salts, Biogen funds huge study. New "treatment& | Views : 3244 | Replies : 1

Oral drug BG-12 helps reduce lesions in MS patients


BG-12 reduces evolution of new enhancing lesions to T1-hypointense lesions in patients with multiple sclerosis.

BG-12, an immunomodulatory agent, reduces frequency of new gadolinium-enhancing (Gd+) lesions in relapsing multiple sclerosis (MS). This study reports the effect of 240 mg BG-12 orally three times daily (tid) for 24 weeks on the evolution of new Gd+ lesions to T1-hypointense lesions.

Brain magnetic resonance imaging (MRI) scans from patients in placebo and 240 mg BG-12 tid arms ...
Read more : Oral drug BG-12 helps reduce lesions in MS patients | Views : 3334 | Replies : 2

fumaric acid esters

Anyone heard about this

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Read more : fumaric acid esters | Views : 1856 | Replies : 2


BG-12 significantly reduced brain lesions in multiple sclerosis 24 October 2008

Biogen Idec announced the publication of Phase IIb data showing that a 240 mg three-times-daily dose of the company's novel oral compound, BG-12 (BG00012, dimethyl fumarate), reduced the number of new gadolinium enhancing (Gd+) lesions by 69 percent in patients with relapsing-remitting multiple sclerosis (MS) when in comparison to therapy with placebo (p<0.0001).

The data also showed a 53 percent reduction in the ...
Read more : BG-12 | Views : 2166 | Replies : 0

BG-12 or fumaric acid anyone ???

I've been taking fumaric acid 240mg 3x a day for four months to treat PPMS. I feel like something positive is happening to my immune system, I'm just not sure what. Does anyone know what the mechanism of BG-12 is supposed to be? Any one in a trial??
Read more : BG-12 or fumaric acid anyone ??? | Views : 4691 | Replies : 6

Any luck with fumaric acid or BG 12 ??

I have been faithfully taking fumaric acid for two months now --240mg TID.
The good news to report is that I have had absolutely no adverse effects so far and I'm feeling better -- less fatigue, normal workload, able to exercise like I want, not as overwhelmed with simple tasks, etc. It's tough for me to tell whether it's the antibiotics or the fumaric acid helping me. What I would like to see is improvement ...
Read more : Any luck with fumaric acid or BG 12 ?? | Views : 4062 | Replies : 3

BG 12 Phase III

Biogen Idec Initiates Phase III Clinical Program of Oral Compound BG-12 for Multiple Sclerosis

Biogen Idec announced today that it has initiated the Phase III clinical program of BG-12, an oral fumarate in development for relapsing-remitting multiple sclerosis (MS).

The DEFINE (determination of the efficacy and safety of oral fumarate in relapsing-remitting MS) and CONFIRM (comparator and an oral fumarate in relapsing-remitting MS) studies will include more than 2,000 total patients in North America, ...
Read more : BG 12 Phase III | Views : 2120 | Replies : 0

Oral fumaric acid esters trial results

Here's the Pubmed entry for the recently completed BG12 study...I think...

Oral fumaric acid esters for the treatment of active multiple sclerosis: an open-label, baseline-controlled pilot study.

Eur J Neurol. 2006 Jun;13(6):604-10.
Schimrigk S, Brune N, Hellwig K, Lukas C, Bellenberg B, Rieks M, Hoffmann V, Pohlau D, Przuntek H.
Department of Neurology, St. Josef Hospital, Ruhr Universitat Bochum, Germany.

An exploratory, prospective, open-label study of fumaric acid esters (FAE, Fumaderm(R)) was conducted in patients ...
Read more : Oral fumaric acid esters trial results | Views : 4950 | Replies : 2


You need to get up earlier to beat me Dignan.

Read more : BG12 | Views : 2617 | Replies : 3

BG-12 Oral Fumarate Phase II ... ewsLang=en

Biogen Idec also announced that a Phase II study of BG-12 in patients with relapsing-remitting multiple sclerosis (MS) was initiated in November 2004. The study, being conducted in Europe, is a placebo-controlled, dose-ranging study designed to assess the efficacy and safety profile of BG-12. The primary endpoint of the study will be an MRI measurement of the amount of brain lesion activity at six months. Approximately ...
Read more : BG-12 Oral Fumarate Phase II | Views : 2551 | Replies : 0


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