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Discuss Tecfidera (BG-12, dimethyl fumarate) as an oral treatment for multiple sclerosis.

JCV and BG-12

Do we know if people who test positive for JCV will be be at more risk to adverse effects on BG-12?

Thanks so much,

Brian
Read more : JCV and BG-12 | Views : 3668 | Replies : 35


BG-12 and LDN?

Thoughts? I know that BG-12 is thought to increase Th2 cells thereby balancing out with Th1 cells and I believe I have read that LDN has a similar effect in increasing Th2 cells (please, correct me if I'm wrong, it's a while since I read it).
To me (my unscientific intuitive speculation of course) it seems that these two drugs would have a complimentary, synergistic effect.
I ask because I am currently taking LDN with ...
Read more : BG-12 and LDN? | Views : 1544 | Replies : 4


FDA extends review of oral MS drug BG-12

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Biotechnology company Biogen Idec Inc said U.S. health regulators extended by three months the review date of its much-awaited multiple sclerosis (MS) drug BG-12, but analysts said the delay was only a minor setback.

Shares of Biogen were down 2 percent at $150.72 in morning trading on the Nasdaq.

The stock has risen more than 50 percent over the past 12 months, largely on optimism about BG-12, which showed robust results in trials and ...
Read more : FDA extends review of oral MS drug BG-12 | Views : 1642 | Replies : 2


wash out period.

has anyones neuro spoke to them about the wash out stage and what they are planning to do in the switch from ty (or anything else) to bg12? i have horrible side effects to solumedrol and dont want to do the 4 week solumedrol wash my neuro is asking. my neuro also has the worst record ive seen on yelp as far as anything and everything medical goes. im not in a position to change ...
Read more : wash out period. | Views : 2093 | Replies : 8


New data support oral BG-12 as MS treatment - Biogen

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Biogen Idec Inc. BIIB said new data from studies evaluating its experimental multiple-sclerosis pill BG-12 further supports its effectiveness and safety in people with relapsing-remitting multiple sclerosis.

Most treatments for the chronic, inflammatory and potentially disabling disease are delivered by needle, but BG-12, or dimethyl fumarate, is an oral drug that will likely be taken twice daily. The drug is currently under review with U.S. and European regulators and could be approved early next ...
Read more : New data support oral BG-12 as MS treatment - Biogen | Views : 851 | Replies : 0


Anyone tempted to get fumaderm straight from Germany?

Hello to all,

I have been thinking about ordering Fumaderm directly from Germany, since my doc already thinks that drug is better than the Copaxone I am taking while waiting. I was wondering if anyone has experience with Canadian or US customs.

Altough that drug is in fact very old, I also wonder if I really fell like taking it so early in its use for the treatment of MS, but that is a completely ...
Read more : Anyone tempted to get fumaderm straight from Germany? | Views : 6969 | Replies : 16


Battle lines drawn in the MS oral drugs market

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For years, patients with multiple sclerosis had to endure injection therapies to stave off the horrible disease. Oral medications have finally emerged from development recently, and it turns out the competition is heating up fast: Results arrived on two major clinical trials for Biogen Idec's own oral MS drug, BG-12, and the data looks rock-solid. With the MS market suddenly red-hot, will Biogen's latest success propel the company to higher heights?

Mopping up the ...
Read more : Battle lines drawn in the MS oral drugs market | Views : 883 | Replies : 0


Expected side effects?

This is a description of the side effects associated with usage of dimethyl fumarate, or fumaderm, for psoriasis.

http://www.nelm.nhs.uk/en/NeLM-Area/Evi ... psoriasis/

Adverse effects, including diarrhoea, abdominal pain and facial flushing, are common at the start of treatment with Fumaderm® and lead to discontinuation and/or non-compliance in 30 to 40% of patients. Reversible leucopenia, lymphopenia and transient eosinophilia are frequently observed


and in more detail...

http://webcache.googleusercontent.com/s ...
Read more : Expected side effects? | Views : 4140 | Replies : 3


Oral drug BG-12 found promising in treatment of MS

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A new oral medication to treat patients in the early stages of multiple sclerosis has shown considerable promise in two clinical trials, researchers announced.

The medication is on track to become just the third oral drug available to M.S. patients, and potentially the safest and most effective, experts said. The second oral drug, called Aubagio, was approved just last week.

M.S. was virtually untreatable only two decades ago, but today nine “disease modifying” drugs ...
Read more : Oral drug BG-12 found promising in treatment of MS | Views : 1868 | Replies : 9


Very Interesting Article on Oxidative Stress and MS......

The author of this paper is the same author (Dr. Jack Van Horssen) who found protandim, dietary supplement more effective
than fumurate derivative BG-12.

Conclusions: Our findings indicate that several Nrf2 activators are able to significantly increase antioxidant enzyme production in oligodendrocytes. Interestingly, protandim, a dietary supplement consisting of herbal ingredients, was the most potent inducer and therefore may be the most suited as a therapeutic strategy. Importantly, Nrf2-mediated antioxidant enzyme expression in oligodendrocytes resulted ...
Read more : Very Interesting Article on Oxidative Stress and MS...... | Views : 2656 | Replies : 7


 

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