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Discuss Tecfidera (BG-12, dimethyl fumarate) as an oral treatment for multiple sclerosis.

Round 2 worse than the 1st

Been on and off tecfidera for 1 month now and it hasn't gotten any easier. First round, got to week 3 no problems then BOOM, curled up in the fetal position with stomach pain. Stopped taking the meds for 4 days then had an allergic reaction to something (?)- hives covered everything from my scalp to my toes (no known allergies prior)…Was on steroids and benedryl and feel like I got that under control and ...
Read more : Round 2 worse than the 1st | Views : 1169 | Replies : 0

Tecfidera® approved in the European Union

Tecfidera® (dimethyl fumarate) has been approved by the European Commission (EC) as a first-line oral treatment for people with relapsing-remitting multiple sclerosis (RRMS), the most common form of multiple sclerosis (MS). Biogen Idec will begin to introduce Tecfidera in initial European Union (EU) countries in the coming weeks..... Read More -
Read more : Tecfidera® approved in the European Union | Views : 1099 | Replies : 0

Tecfidera and glutathione

So, I have been reading about how Tecfidera works by depleting levels of glutathione in your body. In my research I can't find info about whether I should, when I start Tecfidera next week, stop using the glutathione supplement I take? What about other supplements that are supposed to raise levels of glutathione, like milk thistle? If Tecfidera works by depleting glutathione, seems counter-productive to take supplements that increase glutathione. Thoughts?
Read more : Tecfidera and glutathione | Views : 2251 | Replies : 4

BG-12 and IC

I began taking Tecfifera on Sat and noticed my IC is really painful. Wondering if its related to starting this new med.

Anyone else have this issue? My bladder really hurts ;@(
Read more : BG-12 and IC | Views : 1808 | Replies : 2

Tecfidera - cold and flu - Anyone getting sick more?

I was on Tysabri for several years. In September I moved to Tecfidera. I think I have been on it for 3.5 months or so. The stomach issues stopped after the first few weeks, but the flushing happens every time like clockwork. I have gotten used to that as well as much as I can.

My question is, has anyone gotten sick more frequently while on Tecfidera? I have had a cold that just won't ...
Read more : Tecfidera - cold and flu - Anyone getting sick more? | Views : 7605 | Replies : 12

Pterostilbene as an Nrf2 activator

There has been much discussion regarding dimethyl fumarate's role as an Nrf2 activator. The following journal article reports that pterostilbene, which is an extract from blueberries, also activates Nrf2.

Reporter protein complementation imaging assay to screen and study Nrf2 activators in cells and living animals.
Anal Chem. 2013 Aug 6;85(15):7542-9.

    NF-E2-related factor-2 (Nrf2) activators promote cellular defense mechanism and facilitate disease prevention associated with oxidative stress. In the present study, Nrf2 activators were identified using ...
Read more : Pterostilbene as an Nrf2 activator | Views : 1900 | Replies : 2

Good news for Tecfidera in Europe

European Medicines Agency determines that dimethyl fumarate in MS drug Tecfidera qualifies as a new active substance

Biogen Idec Inc. said the European Medicines Agency's Committee for Medicinal Products for Human Use determined that dimethyl fumarate in its drug Tecfidera qualifies as a new active substance...... Read More -
Read more : Good news for Tecfidera in Europe | Views : 1324 | Replies : 0

Stopping Tecfidera to get pregnant

Hey all!

I am new to this forum, but have had MS since 2007. I started Tecfidera about 5 months ago, switching from Avonex. I have a call into my neuro at the moment (since Tuesday anyway) to talk to him about stopping my treatment to get pregnant one more time. What I am curious about is whether or not anyone has any idea on how long you need to be off of Tecfidera before ...
Read more : Stopping Tecfidera to get pregnant | Views : 6627 | Replies : 7

First MRI

Hi. I am happy to report that I have a stable MRI. I started on Tecfidera in May. I was so relieved that this is working for me because I did not want to go back on Avonex! Good luck to all you Tec newbies out there.
Read more : First MRI | Views : 1288 | Replies : 2

HELP!!! First day on Tecfidera. EEEEEEK!!!!!!!!!

OMG this stuff is diabolical! I had my first dose this morning of the 120mg capsule and made sure I ate a high protein breakfast of bacon, sausage, fried egg and toast before taking it. I can't take Aspirin though due to another medical condition. Thanks for the diet tips ;)

The nausea kicked in about an hour after taking it but wasn't too bad, just a ...
Read more : HELP!!! First day on Tecfidera. EEEEEEK!!!!!!!!! | Views : 3347 | Replies : 4


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