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A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis


JC Virus ‘carries mutation that amplifies PML’

A mutation in a mouse model of the John Cunningham (JC) virus, which causes progressive multifocal leukoencephalopathy (PML), allows the virus to evade the host immune responses in people with multiple sclerosis (MS), according to a study into the mechanisms of PML...Read more - http://www.ms-uk.org/MSnews
Read more : JC Virus ‘carries mutation that amplifies PML’ | Views : 707 | Replies : 0


vedolizumab (alternative to natalizumab)

Vedolizumab (Entyvio) is an anti-integrin α4β7 approved for inflammatory bowel disease. Could this be used in someone with a natalizumab allergy or in a resource-poor area? Perhaps this could be a reasonable treatment for someone with both multiple sclerosis and inflammatory bowel disease?

Just curious about anyone's thoughts.

-cent
Read more : vedolizumab (alternative to natalizumab) | Views : 335 | Replies : 0


Natalizumab as a first line of treatment any advice?

Hi All,

I had been recently diagnosed as a case of Multiple sclerosis with active inflammation and had my first attack a month ago. Intravenous steroids were given and am currently on Oral steroids for tapering dosage. I had paraesthesias and visual symptoms in right eye, but after steroid therapy, currently i dont have any symptoms except for Urgency and frequency of urination, no incontinence though. My Neurologist after reviewing my clinical profile and MRI ...
Read more : Natalizumab as a first line of treatment any advice? | Views : 386 | Replies : 4


Tysabri ‘no help in secondary progressive MS’

Tysabri didn't slow disability progression in patients with secondary progressive multiple sclerosis (SPMS).
...Read more - http://www.ms-uk.org/MSnews
Read more : Tysabri ‘no help in secondary progressive MS’ | Views : 566 | Replies : 0


Imaging biomarker diagnoses PML in Tysabri patients

A group of T2 weighted hyperintensities that disseminate in what is called a “punctate pattern” (PP) may directly precede the appearance of progressive multifocal leukoencephalopathy (PML) lesions, according to a new study published in Neurology...Read more - http://www.ms-uk.org/MSnews
Read more : Imaging biomarker diagnoses PML in Tysabri patients | Views : 565 | Replies : 0


Tysabri ‘more effective’ than Gilenya, study claims

A retrospective analysis has found Tysabri is more effective than Gilenya in preventing relapses in patients with relapsing-remitting multiple sclerosis (RRMS)...Read more - http://www.ms-uk.org/MSnews
Read more : Tysabri ‘more effective’ than Gilenya, study claims | Views : 701 | Replies : 0


MS drug linked to rising JC virus antibody levels

People who take the drug Tysabri for multiple sclerosis may have up to a 10 times greater risk of developing a risk biomarker for activity of a virus that can lead to an often fatal brain disease, according to a study published in online issue of Neurology Neuroimmunology and Neuroinflammation..Read more - http://www.ms-uk.org/MSnews
Read more : MS drug linked to rising JC virus antibody levels | Views : 684 | Replies : 0


PML case reported despite negative JCV test

A case of progressive multifocal leukoencephalopathy (PML) associated with Tysabri has been reported in an MS patient who had tested negative for the JC virus (JCV) antibodies just two weeks before symptoms developed...Read more - http://www.ms-uk.org/MSnews
Read more : PML case reported despite negative JCV test | Views : 777 | Replies : 0


Considering Tysabri - questions...

Hello,

I won't repeat a lot of my story, which you can read in all of its turn-of-the-screw (updated! new!) glory here: introductions-f20/topic27058.html

I got some labs back today. I am JCV negative, which is a relief since I'm consideing Tysabri. I haven't seen the actual result to see where I am on the scale yet, but apparently it's below the marker.

I have some questions and would appreciate ...
Read more : Considering Tysabri - questions... | Views : 1464 | Replies : 13


 

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