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A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

Tysabri neutralizing antibodies appear increased by smoking

Natalizumab neutralizing antibodies in MS appear inreased by smoking

Smoking appears to increase the likelihood of developing neutralizing antibodies to natalizumab (Tysabri, Biogen Idec), which cause the drug to have little, if any, therapeutic effect in multiple sclerosis (MS), a new study suggests.

The study was presented by Tomas Olsson, MD, Karolinska Hospital, Stockholm, Sweden, at the recent MS Boston 2014, the 2014 Joint Americas and European Committees for Treatment and Research in Multiple Sclerosis ...
Read more : Tysabri neutralizing antibodies appear increased by smoking | Views : 513 | Replies : 1


PML risk with Natalizumab in MS identified with new test

A new test seems to be able to stratify patients at risk for progressive multifocal leukoencephalopathy (PML) while receiving the multiple sclerosis (MS) drug natalizumab more effectively than anything available at present.

The test is based on observations that patients who develop PML appear to have very low levels of L-selectin (CD62L) on CD4+ T cells in the months or years before they develop the condition..... Read More - http://www.ms-uk.org/tysabri
Read more : PML risk with Natalizumab in MS identified with new test | Views : 257 | Replies : 0


PML Cases Now Reach 486

A rather large jump this past month in Tysabri related PML cases...up 11 to a new total of 486. Not known if any additional deaths were involved. Despite all the JCV screening tests, there doesn't appear to be any let up in the number of MS patients getting PML from Tysabri use.

http://chefarztfrau.de/?page_id=716
Read more : PML Cases Now Reach 486 | Views : 367 | Replies : 1


PML Cases now at 475

The number of Tysabri related PML cases rose by 3 in the past month to 475. Don't know if this means they are screening Tysabri users better before starting on the drug or if fewer patients are using Tysabri.
Read more : PML Cases now at 475 | Views : 460 | Replies : 0


Missing a Dose... what might happen?

Good Morning people! - My purpose of posting this fourm is to get your experiences and thoughts. Here's a little background information:

I am 21 years old, living with MS, and receiving Tysabri infusions every 4 weeks as treatment.

I am a relatively healthy MS patient. Besides a few annoying MS symptoms (typical bowel/bladder), I can run up to 4 miles, I have good endurance, and am a very bright college student.

Next summer, I ...
Read more : Missing a Dose... what might happen? | Views : 502 | Replies : 2


JC virus urinary excretion and seroprevalence.....

JC virus urinary excretion and seroprevalence in natalizumab-treated MS patients

The risk of developing progressive multifocal leukoencephalopathy (PML), as a consequence of infection/reactivation with JC virus (JCV), is consistent in natalizumab-treated multiple sclerosis (MS) patients, with 430 cases of PML reported so far.......... Read More - http://www.ms-uk.org/tysabri
Read more : JC virus urinary excretion and seroprevalence..... | Views : 405 | Replies : 0


Tysabri in India

I am getting ready to start Tysabri due to the fact that I have failed copaxone and rebif now. I am also getting ready to do a year in India(6 months with a month home then another 6 months) site seeing and visiting friends. I have contacted Biogen and found out that yes I can receive infusions over there. I am just trying to find out if anyone on this site might be from Mumbai ...
Read more : Tysabri in India | Views : 1617 | Replies : 0


Increased MS relapse rates after Tysabri discontinuation

Treatment of Relapsing-Remitting Multiple Sclerosis After 24 Doses of Natalizumab -<br>
Evidence From an Italian Spontaneous, Prospective, and Observational Study (the TY-STOP Study)

Marinella Clerico, MD; Irene Schiavetti, BS; Stefania F. De Mercanti, MD; Federico Piazza, MD; Dario Gned, MD; Vincenzo Brescia Morra, MD; Roberta Lanzillo, MD; Angelo Ghezzi, MD; Anna Bianchi, BS; Giuseppe Salemi, MD; Sabrina Realmuto, MD; Patrizia Sola, MD; Francesca Vitetta, MD; Paola Cavalla, MD; Damiano Paolicelli, MD; Maria Trojano, MD; Maria ...
Read more : Increased MS relapse rates after Tysabri discontinuation | Views : 636 | Replies : 0


Tysabri has an effect on oligoclonal bands..........

Tysabri has an effect on oligoclonal bands in the cerebrospinal fluid of MS patients

Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study.

Mancuso R, Franciotta D, Rovaris M, Caputo D, Sala A, Hernis A, Agostini S, Calvo M, Clerici M.

Abstract

Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients.

In this study, we ...
Read more : Tysabri has an effect on oligoclonal bands.......... | Views : 630 | Replies : 0


PML cases now at 472

The number of officially reported Tysabri related PML cases has climbed to 472, an increase of 8 from the previous month. Don't know if any more deaths are included.

http://chefarztfrau.de/?page_id=716
Read more : PML cases now at 472 | Views : 806 | Replies : 0


 

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