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A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

JC virus urinary excretion and seroprevalence.....

JC virus urinary excretion and seroprevalence in natalizumab-treated MS patients

The risk of developing progressive multifocal leukoencephalopathy (PML), as a consequence of infection/reactivation with JC virus (JCV), is consistent in natalizumab-treated multiple sclerosis (MS) patients, with 430 cases of PML reported so far.......... Read More - http://www.ms-uk.org/tysabri
Read more : JC virus urinary excretion and seroprevalence..... | Views : 449 | Replies : 0


Tysabri in India

I am getting ready to start Tysabri due to the fact that I have failed copaxone and rebif now. I am also getting ready to do a year in India(6 months with a month home then another 6 months) site seeing and visiting friends. I have contacted Biogen and found out that yes I can receive infusions over there. I am just trying to find out if anyone on this site might be from Mumbai ...
Read more : Tysabri in India | Views : 1684 | Replies : 0


Increased MS relapse rates after Tysabri discontinuation

Treatment of Relapsing-Remitting Multiple Sclerosis After 24 Doses of Natalizumab -<br>
Evidence From an Italian Spontaneous, Prospective, and Observational Study (the TY-STOP Study)

Marinella Clerico, MD; Irene Schiavetti, BS; Stefania F. De Mercanti, MD; Federico Piazza, MD; Dario Gned, MD; Vincenzo Brescia Morra, MD; Roberta Lanzillo, MD; Angelo Ghezzi, MD; Anna Bianchi, BS; Giuseppe Salemi, MD; Sabrina Realmuto, MD; Patrizia Sola, MD; Francesca Vitetta, MD; Paola Cavalla, MD; Damiano Paolicelli, MD; Maria Trojano, MD; Maria ...
Read more : Increased MS relapse rates after Tysabri discontinuation | Views : 714 | Replies : 0


Tysabri has an effect on oligoclonal bands..........

Tysabri has an effect on oligoclonal bands in the cerebrospinal fluid of MS patients

Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study.

Mancuso R, Franciotta D, Rovaris M, Caputo D, Sala A, Hernis A, Agostini S, Calvo M, Clerici M.

Abstract

Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients.

In this study, we ...
Read more : Tysabri has an effect on oligoclonal bands.......... | Views : 689 | Replies : 0


PML cases now at 472

The number of officially reported Tysabri related PML cases has climbed to 472, an increase of 8 from the previous month. Don't know if any more deaths are included.

http://chefarztfrau.de/?page_id=716
Read more : PML cases now at 472 | Views : 864 | Replies : 0


Study suggests Tysabri safe past 24 months

Study suggests MS drug Tysabri treatment can be safely continued past 24 months

A recent study suggests that treatment with natalizumab (Tysabri) beyond 2 years compared with switching to other drugs can control relapsing-remitting multiple sclerosis (RRMS) with adequate safety.

The longer a patient with RRMS is treated with natalizumab, the greater the risk of developing progressive multifocal leukoencephalopathy (PML), especially in patients who are infected with JC virus after 2 years of monthly treatments. ...
Read more : Study suggests Tysabri safe past 24 months | Views : 724 | Replies : 1


MS rebound after stopping Tysabri

Abnormal inflammatory activity returns after natalizumab cessation in multiple sclerosis.

Gueguen A, Roux P, Deschamps R, Moulignier A, Bensa C, Savatovsky J, Heran F, Gout O.

Abstract

OBJECTIVE: To characterise recurrence of multiple sclerosis (MS) inflammatory activity during the year following natalizumab (NTZ) cessation..... Read More - http://www.ms-uk.org/tysabri
Read more : MS rebound after stopping Tysabri | Views : 676 | Replies : 2


Age and it's effects on response to MS treatment Tysabri

Age-dependent effects on the treatment response of natalizumab in MS patients.

Matell H, Lycke J, Svenningsson A, Holmén C, Khademi M, Hillert J, Olsson T, Piehl F.

Abstract

BACKGROUND: Natalizumab is approved for treatment of active forms of relapsing-remitting multiple sclerosis (MS) based on a pivotal phase III study comprising patients aged 18-50 years. The effect of natalizumab has not been specifically studied in older patients...... Read More - http://www.ms-uk.org/tysabri
Read more : Age and it's effects on response to MS treatment Tysabri | Views : 779 | Replies : 1


PML Cases now Reach 464

The number of reported PML cases from using Tysabri has jumped by 10 up to 464. Certainly not seeing any slowdown in this area. Don't know if any more deaths are involved.

http://chefarztfrau.de/?page_id=716
Read more : PML Cases now Reach 464 | Views : 577 | Replies : 0


The RESTORE trial: What did we learn about MS?

RESTORE was a randomized, partially placebo-controlled exploratory study evaluating multiple sclerosis (MS) disease activity during a 24-week interruption of natalizumab. The objectives of RESTORE were to explore the course of MS disease activity and the effects on pharmacokinetic, pharmacodynamic, and immune parameters in patients undergoing an interruption of natalizumab therapy for up to 24 weeks as compared with those in patients remaining on natalizumab. It also assessed the effects of alternate therapies during natalizumab interruption ...
Read more : The RESTORE trial: What did we learn about MS? | Views : 847 | Replies : 1


 

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