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A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

Age and it's effects on response to MS treatment Tysabri

Age-dependent effects on the treatment response of natalizumab in MS patients.

Matell H, Lycke J, Svenningsson A, Holmén C, Khademi M, Hillert J, Olsson T, Piehl F.

Abstract

BACKGROUND: Natalizumab is approved for treatment of active forms of relapsing-remitting multiple sclerosis (MS) based on a pivotal phase III study comprising patients aged 18-50 years. The effect of natalizumab has not been specifically studied in older patients...... Read More - http://www.ms-uk.org/tysabri
Read more : Age and it's effects on response to MS treatment Tysabri | Views : 656 | Replies : 1


PML Cases now Reach 464

The number of reported PML cases from using Tysabri has jumped by 10 up to 464. Certainly not seeing any slowdown in this area. Don't know if any more deaths are involved.

http://chefarztfrau.de/?page_id=716
Read more : PML Cases now Reach 464 | Views : 485 | Replies : 0


The RESTORE trial: What did we learn about MS?

RESTORE was a randomized, partially placebo-controlled exploratory study evaluating multiple sclerosis (MS) disease activity during a 24-week interruption of natalizumab. The objectives of RESTORE were to explore the course of MS disease activity and the effects on pharmacokinetic, pharmacodynamic, and immune parameters in patients undergoing an interruption of natalizumab therapy for up to 24 weeks as compared with those in patients remaining on natalizumab. It also assessed the effects of alternate therapies during natalizumab interruption ...
Read more : The RESTORE trial: What did we learn about MS? | Views : 761 | Replies : 1


undiagnosed....walk for a living and legs declining rapidly

I am a mail carrier. Have mri of brain indicative of ms. Ins wont pay for cervical thoracic mri. Rheumatoligist rules out everything and says its ms. On gabapentin, zanaflez and provigil now. But no diagnosis. Meanwhile...2 episodes to er and steroid injections. My legs have such spasticity i can hardly bend them. I walk through yards and rough terrain all day. Doctor put me to 5 days a week 6 hours a day. Now ...
Read more : undiagnosed....walk for a living and legs declining rapidly | Views : 691 | Replies : 5


New Data for MS drug Tysabri released at AAN annual meeting

- New Tysabri® analysis shows improved walking speed in significant number of MS patients.

- Additional data show escalation to Tysabri following relapse improves clinical outcomes compared to remaining on or switching between first-line Interferon Beta and Glatiramer Acetate.............. Read More - http://www.ms-uk.org/tysabri
Read more : New Data for MS drug Tysabri released at AAN annual meeting | Views : 748 | Replies : 1


PML Cases now reach 454!

The number of reported PML cases has risen 6 more to 454. Don't know if any deaths are included in this number.


http://chefarztfrau.de/?page_id=716
Read more : PML Cases now reach 454! | Views : 475 | Replies : 0


New clues to link between MS drug Tysabri and PML

Researchers report drug mobilizes a kind of cell easily infected by a virus that attacks the brain.

Researchers report that they think they have figured out why patients who take the multiple sclerosis drug Tysabri face a high risk of developing a rare, and sometimes fatal, brain infection....... Read More - http://www.ms-uk.org/tysabri
Read more : New clues to link between MS drug Tysabri and PML | Views : 695 | Replies : 3


PML Cases Now Reach 448

The number of Tysabri related PML cases has increased by 9 over the previous month, bringing the new total to 438. It isn't known if there are any deaths included in this figure.

These are the cases reported by Biogen and may not reflect the real number of PML cases encountered by MS patients using Tysabri.


http://chefarztfrau.de/?page_id=716
Read more : PML Cases Now Reach 448 | Views : 582 | Replies : 0


No definite melanoma link for Tysabi...

Australian regulator finds no definite melanoma link for Tysabri

Australia’s Therapeutic Goods Administration (TGA) revealed today that it is monitoring reports of melanoma in patients being treated with natalizumab and encourages consumers and health professionals to report all such cases....... Read More - http://www.ms-uk.org/tysabri
Read more : No definite melanoma link for Tysabi... | Views : 430 | Replies : 1


Tysabri is a dangerous drug

Brief background, I used to work in the FDA program that handled drugs monitored under the Risk Evaluation and Mitigation Strategy program. The FDA requires that if a death (or adverse event) arises from the drug, it must be reported. BUT, they do not require the drug companies to proactively obtain that information. So the only way we recorded death info is if the doctor causally calls about ordering forms, and just so happens to ...
Read more : Tysabri is a dangerous drug | Views : 1761 | Replies : 5


 

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