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A board to discuss the newly-released drug Tysabri, (formerly known as Antegren) as a treatment for Multiple Sclerosis

Natalizumab treatment reduces fatigue in multiple sclerosis

Fatigue is a significant symptom in multiple sclerosis (MS) patients. First-generation disease modifying therapies (DMTs) are at best moderately effective to improve fatigue.

Observations from small cohorts have indicated that natalizumab, an antibody targeting VLA-4, may reduce MS-related fatigue. The TYNERGY study aimed to further evaluate the effects of natalizumab treatment on MS-related fatigue...... Read More - http://www.ms-uk.org/index.cfm/tysabri
Read more : Natalizumab treatment reduces fatigue in multiple sclerosis | Views : 868 | Replies : 1


Biogen Idec gains commercial rights of Tysabri from Elan

Biogen Idec gains commercial rights of Tysabri from Elan Corporation

Biogen Idec has completed its purchase of Elan Corporation’s interest in Tysabri (natalizumab) and has gained full strategic, commercial and decision-making rights of Tysabri. The transaction was originally announced on February 6, 2013....................Read More - http://www.ms-uk.org/index.cfm/tysabri
Read more : Biogen Idec gains commercial rights of Tysabri from Elan | Views : 678 | Replies : 1


New Tysabri And Anti-JCV Antibody Stability Data Released

New Tysabri And Anti-JCV Antibody Stability Data Released

Biogen Idec and Elan Corporation, plc announced results from several studies of Tysabri(R) (natalizumab) that demonstrate its efficacy compared to other multiple sclerosis (MS) treatments, provide additional data supporting anti-JC virus (JCV) antibody status stability, and suggest better outcomes when progressive multifocal leukoencephalopathy (PML) is detected early. These data will be presented at the 65th Annual Meeting of the American Academy of Neurology (AAN) in San Diego.........Read ...
Read more : New Tysabri And Anti-JCV Antibody Stability Data Released | Views : 1034 | Replies : 0


Early Magnetic Resonance Detection Natalizumab-Related PML

Early Magnetic Resonance Detection of Natalizumab-Related Progressive Multifocal Leukoencephalopathy in a Patient with Multiple Sclerosis

Diagnosis of progressive multifocal leukoencephalopathy is usually based on the clinical presentation, on the demonstration of the brain lesions at the magnetic resonance imaging examination, and on the detection of the JC virus DNA in the cerebrospinal fluid with high sensitive polymerase chain reaction..... Read More - http://www.ms-uk.org/index.cfm/tysabri
Read more : Early Magnetic Resonance Detection Natalizumab-Related PML | Views : 669 | Replies : 0


Early Detection of MS Treatment Complication May Improve...

Early Detection of MS Treatment Complication May Improve Survival

The drug natalizumab is effective for treating multiple sclerosis (MS), but it increases the risk of a rare but potentially fatal brain infection called progressive multifocal leukoencephalopathy (PML). A study released today that will be presented at the American Academy of Neurology’s 65th Annual Meeting in San Diego, March 16 to 23, 2013, suggests that early detection of PML may help improve survival and disability levels. ...
Read more : Early Detection of MS Treatment Complication May Improve... | Views : 667 | Replies : 1


Gilenya doesn't stop post Tysabri reactivation

Taking Gilenya after stopping Tysabri doesn't suppress MS reactivation
http://www.overcomingmultiplesclerosis. ... ctivation/
Read more : Gilenya doesn't stop post Tysabri reactivation | Views : 986 | Replies : 5


PMLCases now reach 331

As of Feb 05, the new total of PML cases has increased by 8, making the new total 331. Don't know if any more deaths are involved in the additional 8 cases.

http://chefarztfrau.de/?page_id=716

Harry
Read more : PMLCases now reach 331 | Views : 908 | Replies : 1


An assay to quantify species-specific anti-JC virus antibody

An assay to quantify species-specific anti-JC virus antibody levels in MS patients

Summary: This study looked at developing an assay for the reliable quantification of highly species-specific anti-JCV antibody levels and to compare the results with pre-existing data from the StratifyJCV® test.

The researchers tested the sera of 175 MS patients and matched non-MS-controls for anti-JCV antibodies using glutathione S-transferase-tagged-VP1 as antigen. In order to minimise the cross-reactivity between shared epitopes of JCV-VP1 and BKV-VP1, ...
Read more : An assay to quantify species-specific anti-JC virus antibody | Views : 793 | Replies : 0


Tysabri may be an option for children with MS

Tysabri may be an option for children with Multiple Sclerosis

Off-label treatment with natalizumab (Tysabri) for 20 children with severe multiple sclerosis reduced relapses and brain lesions seen on MRI scans, a retrospective analysis found.

The mean annualized relapse rate while on natalizumab in these patients was 0.4, compared with 3.77 before starting the drug (P<0.001), according to Barbara Kornek, MD, of Austria's Medical University of Vienna, and colleagues.

Also, new T2/fluid attenuated inversion recovery ...
Read more : Tysabri may be an option for children with MS | Views : 594 | Replies : 0


Natalizumab in pediatric multiple sclerosis

Natalizumab in paediatric multiple sclerosis: results of a cohort of 55 cases

Abstract

BACKGROUND: Limited information is available on the use of natalizumab (NA) in pediatric multiple sclerosis (ped-MS) patients.

OBJECTIVE: The purpose of this study was to describe the long-term effects of NA in a large cohort of active ped-MS patients.

METHODS: Patients with definite ped-MS were treated with NA if in the previous year they had experienced at least two relapses or a ...
Read more : Natalizumab in pediatric multiple sclerosis | Views : 1011 | Replies : 0


 

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