Hello. I did a full course of Novantrone in 2000-2003 and it was very successful for me. My RR MS was downgrading to the next stage, so my neuro put me on Novantrone. I believe that Novantrone brought my downward spiral to a halt and the MRIs in 2000-2003 bear this out.
Even though this is chemotherapy and sounds scary, I experienced none of the symptoms or effects that one would expect.
As a precaution, I had a MUGA scan of my heart done before therapy and once each year, and a followup MUGA scan afterward. This is similar to a doppler radar picture of how hard your heart muscle pumps.
I had to have an oncologist administer the Novantrone. He was very comfortable with what he saw as a low dosage of Novantrone and its use for MS. Regarding heart toxicity, his position was that Novantrone is within a class of drugs that have heart muscle toxicity problems, but that there was no specific evidence that he knew of directly linking Novantrone to this effect. (Get your own opinion on this topic, other doctors may disagree.) I valued the oncologist's opinion because he was familiar with the use of this drug in much larger doses for longer periods of time.
The Novantrone itself did not have any side effects on me. The decadron (sp?) they give before the novantrone infusion made me feel creepy, but once I had them switch out the decadron with IV steroids, I had no side effects or uncomfortable feelings.
Novantrone was very successful for me. I know these types of treatments sound scary, and to some extent they are. But once you get into it, inform yourself, and make the decision, I believe you will be very suprised how side-effect free the treatment can be.