New drug reduces progression for primary progressive MS....

Discuss Ocrelizumab, a monoclonal antibody treatment for MS.

Re: New drug reduces progression for primary progressive MS.

Postby ton » Mon Oct 05, 2015 9:14 am

Please visit this brilliant blog:
http://www.wheelchairkamikaze.com/
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Re: New drug reduces progression for primary progressive MS.

Postby MSbro » Mon Oct 05, 2015 11:02 am

ton wrote:Please visit this brilliant blog:
http://www.wheelchairkamikaze.com/


What's the saying..."deja vue all over again"!!!
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Re: New drug reduces progression for primary progressive MS.

Postby ton » Mon Oct 05, 2015 12:11 pm

Perhaps it could be "déjà vécu"...
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Re: New drug reduces progression for primary progressive MS.

Postby Leonard » Tue Oct 06, 2015 12:54 am

quote from: http://www.wheelchairkamikaze.com/
Had Roche pushed ahead with its Rituxan MS trials even in the face of a looming patent expiration we might have had another very effective treatment for RRMS, and perhaps even PPMS, for at least the last five years. Alas, ‘twas not to be, quite likely because Rituxan was scheduled to soon lose its patent protection. unquote

If true, which can not be excluded, this is a serious allegation and a sign that this pharmaceutical industry is not interested in solving our problem, rather that it is the money that counts.

Since 1995/96 over 700,000 patients have been treated with Rituximab: http://www.ema.europa.eu/docs/en_GB/doc ... 025822.pdf
Rituximab would appear safe.
I understand it is produced from hamsters in Vacaville Cal. There is a report on the ema website reporting about a contamination incident.

There are questions with regard to the safety of Ocrelizumab. The trials for RA and lupus were stopped. For sure, it will be loaded with new patents which will be reflected in the price...

I think the main issue with these "mabs" is not whether it is A or B or C, but how the medication is administered. If only intravenous, the medication does not perculate sufficiently into the spinal column. And would appear less effective.
That is why some recent experiments in the program of the Progressive MS Alliance also have intrathecal administration. And it seems quite succesfull in depleting B-cells in the spinal column and CNS.
See this article: http://www.ncbi.nlm.nih.gov/pubmed/25745637
and the last few postings on this page 49: general-discussion-f1/topic15188-720.html
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Re: New drug reduces progression for primary progressive MS.

Postby CureOrBust » Tue Mar 08, 2016 5:38 am

I asked one of my Neuro's about this, and he said that the trial with PPMS, that showed such promise, actually included PPMS patients that showed enhancing lesions on MRI. Huh? ie their clinical selection criteria to define PPMS was questionable :confused: . When asked how the numbers were on removing these patients from the statistics, they supposedly replied they had not run those numbers. really? :-|
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Re: New drug reduces progression for primary progressive MS.

Postby 1eye » Tue Mar 08, 2016 4:41 pm

Really. The absence of science in medicine, pursuit of whatever will generate the most revenue in spite of any safety concerns, the complete abandonment of the people who struggle with disease, when patent protection fails, are not by any means new to these drug dealers. There is a drug known to help people with IBD and thought to help pwMS, called naltrexone, which has no patent protection, therefore is not even tested by any scientists or drug companies. MS will be beaten but it will not be because of, but in spite of, medical help.

Make your own 300 mg/day doses of biotin. I am on my 4th batch of 100. Rice bran filler is high in vitamin B. This substance has not been tested on RRMS. Be the first on your block to try it!
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Re: New drug reduces progression for primary progressive MS.

Postby David1949 » Wed Mar 09, 2016 11:24 am

1 eye
Do you have any quantifiable results that show Biotin has improved your condition such as edss score or 25 foot timed walk?
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Re: New drug reduces progression for primary progressive MS.

Postby 1eye » Wed Mar 09, 2016 8:40 pm

No. I am not in a clinical trial, nor am I qualified even if testing myself could be unbiased. Nobody is testing me. I expect I will do better once the snow is gone from the sidewalks.
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