I'm about 7 months post-diagnosis, and so I feel like I'm at the bottom of a huge mountain of reading, but an acquaintance who has MS lent me a trove of books, and this is the second one I got into. (The first one, which actually I bought after doing internet research, was Prof. Swank's book, and the third one, also on my own, was Prof. Jelinek's book.) I got about 2/3 of the way through Weiner's book, stopped because I was busy with work, and am now rereading it. I think it's definitely a worthwhile read.
Even if you place more stock in theories and approaches that are outside the mainstream, I think you've got to understand the mainstream approach, and that means reading its history. As others have written above, this book is an encapsulation of a 30 year career of a doctor at the forefront of his field working at one of the best hospitals and research centers in the USA. It's very educational and interesting to follow the theories that have been propounded, tested, adjusted, etc. It's essential to see how science works, how research gets done, with all the pros and cons of the process.
As I search for a neurologist whose attitude, aptitude, and approach fits with mine, I want to understand EVERYTHING, even if only in broad strokes, that is going on with research into MS. It may be a tall order, but I don't expect it to happen all at once. This book is a great place to start.
p.s. It also introduces a lot of the top players in today's research scene -- they were often the junior colleagues of Dr. Weiner in his days at Massachusetts General Hospital, etc.