This Is MS Multiple Sclerosis Community: Knowledge & Support

Been shooting up for about 6 years now. Other then the red patches on my belly, no real side effects that I can attribute to Rebif. Has anyone read about or experienced anything that could be attributed to long term use, say 5 plus years.

Likewise (7 yrs for me). I have the same question about long term effects from using interferon. I haven't found any studies or information yet.

I started Rebif in 2000.
It took a few months to calm down the MS and since then, I've had few relapses.
I had an MRI in 2009, after a relapse whilst I wasn't on Rebif (moved countries). I had only 4 lesions in 9 years, which corresponded to the relapses.
I still have injection site blotches, my liver enzymes are fine and I also take LDN.
Apart from the red splotches, I have no concerns with Rebif at all and my neurologist thinks that I haven't moved into SPMS, which may be down to pure luck or pure luck and Rebif. As it's MS, you can never know for sure.

jg

These responses have helped me immensely. I've only begun Rebif about 8 months ago. I do get injection site redness, which then stays looking like a bruise for a week or so. Generally, if I remember to take Tylenol shortly before my injection, I don't usually get any reaction. I have however, experienced awful chills and shaking if I do not remember to take the Tylenol ahead of time (who knew that little anti-inifammatory could really do SO much). I've not yet had any follow-up MRI, and truthfully, I haven't noticed much improvement (YET), but I'm hopeful that my neurologist knows what he is doing. Right now, I'm seriously looking into the CCSVI option as well for more immediate relief and trying to be preactive. I do kinda question what this Rebif is doing to my system; I suppose that's yet to be seen.