Interferon at first sign of MS delays progression

A board to discuss the Multiple Sclerosis modifying drug Rebif

Interferon at first sign of MS delays progression

Postby MSUK » Mon Jun 06, 2011 1:18 am


Starting interferon-beta-1a (Rebif New Formulation) immediately upon an episode of a clinically isolated syndrome delayed progression to full-blown multiple sclerosis, but once-weekly treatment was less effective than the standard dosing interval, a researcher said here.

A randomized, placebo-controlled trial called REFLEX showed that 62% and 76% of patients assigned to 44 mcg of interferon subcutaneously three times or once weekly, respectively, met 2005 McDonald criteria for MS after two years -- the study's primary endpoint -- compared with 86% of patients treated with placebo, said Mark Freedman, MD, of the University of Ottawa.... Read More - ... ageid/1765
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