A Very Important thing about ReBif.... The manufacturer of the drug ask that all physicians prescribing ReBif require a psychological consult before a patient starts treatment. This is a serious thing, GET IT DONE. If you have ever had problems with depression(which is good friends with MS), get a psych consult first, please. I live in Seattle, home of MS, I had a Neurologist here that put me on Rebif at my second major and fully diagnosable attack. Problem was, it was also one month after my mother died. According to the Nurses Line on Rebif box, I should have never of been put on the drug while still in a grieving state. My experience with ReBif included flu like symptoms, bizarre vivid dreams, crying for no reason and finally a loaded firearm in my mouth. Luckily, the FedEx lady arrived and I answered the door. That is why I am here today. I am not a suicidal person, even knowing I have MS. Again, the manufacturer is the way I found out that this drug can cause major problems if one suffers from depression, not from my now former Neurologist who skipped the psych consult part. I then went back to my original Neuro who discovered the MS via Optic Neuritis a few years earlier. I told him about the ReBif incident and for the first time in my 38 years of living, a doctor spoke ill of another doctor. So I can not emphasize enough that one meets with a psychologist or psychiatrist before taking this drug. I went from normal MS patient to suicidal, crying basket case in three months. And my life is pretty good, i'm an attractive man, I have a beautiful wife that makes a good living, I don't have to work, we have money; no reason to kill myself but on the ReBif it almost happened. Funny thing was, the FedEx lady that knocked on my door, she was delivering my next supply of ReBif. I am now on Copaxone.