I am on Rebif44 for 4,5 years now. I had my 1st attack in October 2006, was diagnosed in December 2006 and started Rebif in February or March 2007. I had 1 relapse in April 2007, which means after a few weeks of treatment, I had some family problems etc. and was very stressed during that time.
Since that relapse in 2007 I had no attack, I have currently no MS symptoms, my MRI looks fine. Of course it is possible that this is not due to Rebif, but I don't care, I am happy that Rebif seems to work for me.
I inject Sunday, Tuesday, Thursday before I go to sleep and I take 400mg Ibuprofen with the injection. For the first months when I started Rebif, I had to take up to 1200 mg Ibuprofen, otherwise I had these flu syptoms and fever. I have noted that the side effects are more severe when I inject in my belly, this is why I use legs and bottom only. I prefer manual injection, too, I don't like the Rebiject very much, but I have to use it to inject in my backside
My skin is still okay, sometimes the injection sides get red and when I expose them to the sun, they swell a bit.
So I am happy with Rebif, but for my sister, who has MS as well, Rebif did not work. She switched to Copaxone and is now free of relapses, but has some problems wiht her skin.
To sum up, try it for some months, take ibuprofen to fight the side effects and switch, if it does not work. Good luck